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Clonal hematopoiesis

MedGen UID:
1694554
Concept ID:
C5206406
Finding
Synonyms: Clonal Hematopoiesis; Hematopoiesis, Clonal
SNOMED CT: Clonal hematopoiesis (1240416002)
 
Monarch Initiative: MONDO:0100542

Definition

Cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage. [from NCI]

Professional guidelines

PubMed

Collord G, Behjati S
Cancer Discov 2023 Apr 3;13(4):811-813. doi: 10.1158/2159-8290.CD-23-0090. PMID: 37009705
Krebs MG, Malapelle U, André F, Paz-Ares L, Schuler M, Thomas DM, Vainer G, Yoshino T, Rolfo C
JAMA Oncol 2022 Dec 1;8(12):1830-1839. doi: 10.1001/jamaoncol.2022.4457. PMID: 36264554
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Recent clinical studies

Etiology

Kang TG, Lan X, Mi T, Chen H, Alli S, Lim SE, Bhatara S, Vasandan AB, Ward G, Bentivegna S, Jang J, Spatz ML, Han JH, Schlotmann BC, Jespersen JS, Derenzo C, Vogel P, Yu J, Baylin S, Jones P, O'Connell C, Grønbæk K, Youngblood B, Zebley CC
Science 2024 Oct 11;386(6718):eadl4492. doi: 10.1126/science.adl4492. PMID: 39388542
Vlasschaert C, Robinson-Cohen C, Chen J, Akwo E, Parker AC, Silver SA, Bhatraju PK, Poisner H, Cao S, Jiang M, Wang Y, Niu A, Siew E, Van Amburg JC, Kramer HJ, Kottgen A, Franceschini N, Psaty BM, Tracy RP, Alonso A, Arking DE, Coresh J, Ballantyne CM, Boerwinkle E, Grams M, Zhang MZ, Kestenbaum B, Lanktree MB, Rauh MJ, Harris RC Jr, Bick AG
Nat Med 2024 Mar;30(3):810-817. Epub 2024 Mar 7 doi: 10.1038/s41591-024-02854-6. PMID: 38454125Free PMC Article
Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, Lasry A, Redondo LZ, Choi K, Gong Y, Walker CS, Hueneman K, Bolanos LC, Barreyro L, Lee LH, Greis KD, Vasyliev N, Khodadadi-Jamayran A, Nudler E, Lujambio A, Lowe SW, Aifantis I, Starczynowski DT
Cell Stem Cell 2022 Feb 3;29(2):298-314.e9. Epub 2022 Jan 18 doi: 10.1016/j.stem.2021.12.007. PMID: 35045331Free PMC Article
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA Jr, Levine RL, Morton LM, Zehir A, Papaemmanuil E
Nat Genet 2020 Nov;52(11):1219-1226. Epub 2020 Oct 26 doi: 10.1038/s41588-020-00710-0. PMID: 33106634Free PMC Article

Diagnosis

Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL
J Exp Med 2021 Dec 6;218(12) Epub 2021 Oct 26 doi: 10.1084/jem.20211872. PMID: 34698806Free PMC Article
Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA Jr, Levine RL, Morton LM, Zehir A, Papaemmanuil E
Nat Genet 2020 Nov;52(11):1219-1226. Epub 2020 Oct 26 doi: 10.1038/s41588-020-00710-0. PMID: 33106634Free PMC Article
Kishtagari A, Levine RL, Viny AD
Curr Opin Hematol 2020 Mar;27(2):49-57. doi: 10.1097/MOH.0000000000000567. PMID: 31972687Free PMC Article
Wang L, Liu H
Hematology 2019 Dec;24(1):559-566. doi: 10.1080/16078454.2019.1642548. PMID: 31315542
Wang SA
Pathobiology 2019;86(1):39-52. Epub 2018 Jun 29 doi: 10.1159/000489341. PMID: 29961056

Therapy

Kang TG, Lan X, Mi T, Chen H, Alli S, Lim SE, Bhatara S, Vasandan AB, Ward G, Bentivegna S, Jang J, Spatz ML, Han JH, Schlotmann BC, Jespersen JS, Derenzo C, Vogel P, Yu J, Baylin S, Jones P, O'Connell C, Grønbæk K, Youngblood B, Zebley CC
Science 2024 Oct 11;386(6718):eadl4492. doi: 10.1126/science.adl4492. PMID: 39388542
Buckley LF, Libby P
Arterioscler Thromb Vasc Biol 2024 May;44(5):1031-1041. Epub 2024 Mar 21 doi: 10.1161/ATVBAHA.124.319851. PMID: 38511324Free PMC Article
Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S
Nat Med 2023 Jul;29(7):1662-1670. Epub 2023 Jun 15 doi: 10.1038/s41591-023-02397-2. PMID: 37322115Free PMC Article
Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K
Trends Mol Med 2023 Jul;29(7):530-540. Epub 2023 Apr 29 doi: 10.1016/j.molmed.2023.04.002. PMID: 37121869
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486

Prognosis

Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Szybinski J, Meyer SC
Hematol Oncol Clin North Am 2021 Apr;35(2):217-236. Epub 2021 Jan 29 doi: 10.1016/j.hoc.2020.12.002. PMID: 33641865
Kishtagari A, Levine RL, Viny AD
Curr Opin Hematol 2020 Mar;27(2):49-57. doi: 10.1097/MOH.0000000000000567. PMID: 31972687Free PMC Article

Clinical prediction guides

Libby P
Vascul Pharmacol 2024 Mar;154:107255. Epub 2023 Dec 28 doi: 10.1016/j.vph.2023.107255. PMID: 38157682
Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S
Nat Med 2023 Jul;29(7):1662-1670. Epub 2023 Jun 15 doi: 10.1038/s41591-023-02397-2. PMID: 37322115Free PMC Article
Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez-Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, Stäble S, Walter D, Petri A, Carreño-Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers MAG, Weru V, Holland-Letz T, Mallm JP, Rippe K, Krämer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD
Cell Stem Cell 2022 Aug 4;29(8):1273-1284.e8. Epub 2022 Jul 19 doi: 10.1016/j.stem.2022.06.012. PMID: 35858618Free PMC Article
George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA
Nat Genet 2020 Apr;52(4):378-387. Epub 2020 Mar 23 doi: 10.1038/s41588-020-0595-4. PMID: 32203468Free PMC Article

Recent systematic reviews

Xie Y, Kazakova V, Weeks LD, Gerber JM, Tai J, Zhang TY, Lowsky R, Wu X, Yang C, Patel SA
Bone Marrow Transplant 2024 Nov;59(11):1585-1593. Epub 2024 Aug 25 doi: 10.1038/s41409-024-02403-2. PMID: 39183321Free PMC Article
Singh J, Li N, Ashrafi E, Thao LTP, Curtis DJ, Wood EM, McQuilten ZK
Blood Adv 2024 Jul 23;8(14):3771-3784. doi: 10.1182/bloodadvances.2024013228. PMID: 38838228Free PMC Article
Ma J, Zhang B, Song H, Wu D, Song T
Int J Implant Dent 2023 Dec 6;9(1):48. doi: 10.1186/s40729-023-00517-8. PMID: 38055096Free PMC Article
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Nowakowska MK, Kim T, Thompson MT, Bolton KL, Deswal A, Lin SH, Scheet P, Wehner MR, Nead KT
Am J Hematol 2022 Apr;97(4):411-420. Epub 2022 Jan 19 doi: 10.1002/ajh.26465. PMID: 35015316Free PMC Article

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