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Heparin-induced thrombocytopenia(HIT)

MedGen UID:
124423
•Concept ID:
C0272285
•
Disease or Syndrome
Synonym: HIT
SNOMED CT: Heparin-induced thrombocytopenia (73397007); Heparin induced thrombocytopenia (73397007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011874
Monarch Initiative: MONDO:0018048
Orphanet: ORPHA3325

Definition

Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeparin-induced thrombocytopenia
Follow this link to review classifications for Heparin-induced thrombocytopenia in Orphanet.

Professional guidelines

PubMed

Treatment of drug-induced immune thrombocytopenias.
Marini I, Uzun G, Jamal K, Bakchoul T
Haematologica 2022 Jun 1;107(6):1264-1277. doi: 10.3324/haematol.2021.279484. PMID: 35642486Free PMC Article
Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628

Recent clinical studies

Etiology

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-Induced Thrombocytopenia.
Frazer CA
J Infus Nurs 2017 Mar/Apr;40(2):98-100. doi: 10.1097/NAN.0000000000000215. PMID: 28248809
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576
Heparin-induced thrombocytopenia.
Bambrah RK, Pham DC, Zaiden R, Vu H, Tai S
Clin Adv Hematol Oncol 2011 Aug;9(8):594-9. PMID: 22236986

Diagnosis

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
How Can I Manage Thrombocytopenia in Hemodialysis Patient? A Review.
Guo Q, Lou Y, Liu L, Luo P
Ther Apher Dial 2020 Aug;24(4):352-360. Epub 2019 Dec 2 doi: 10.1111/1744-9987.13448. PMID: 31661590
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576
Heparin-induced thrombocytopenia.
Bambrah RK, Pham DC, Zaiden R, Vu H, Tai S
Clin Adv Hematol Oncol 2011 Aug;9(8):594-9. PMID: 22236986

Therapy

Heparin-induced thrombocytopenia.
Jevtic SD, Morris AM, Warkentin TE, Pai M
CMAJ 2021 May 17;193(20):E736. Epub 2021 Apr 27 doi: 10.1503/cmaj.210637. PMID: 33906965Free PMC Article
Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-Induced Thrombocytopenia.
Frazer CA
J Infus Nurs 2017 Mar/Apr;40(2):98-100. doi: 10.1097/NAN.0000000000000215. PMID: 28248809
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Prognosis

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.
Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S
N Engl J Med 2021 Jun 3;384(22):2092-2101. Epub 2021 Apr 9 doi: 10.1056/NEJMoa2104840. PMID: 33835769Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-Induced Thrombocytopenia and Cardiac Surgery.
Solanki J, Shenoy S, Downs E, Palkimas S, Goldman S, Sharma AM
Semin Thorac Cardiovasc Surg 2019 Autumn;31(3):335-344. Epub 2018 Nov 15 doi: 10.1053/j.semtcvs.2018.10.011. PMID: 30448485
Heparin-induced thrombocytopenia.
Greinacher A, Fürll B, Selleng S
Methods Mol Biol 2013;992:301-18. doi: 10.1007/978-1-62703-339-8_23. PMID: 23546723
Heparin-induced thrombocytopenia.
Greinacher A
J Thromb Haemost 2009 Jul;7 Suppl 1:9-12. doi: 10.1111/j.1538-7836.2009.03385.x. PMID: 19630757

Clinical prediction guides

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Drug-associated thrombocytopenia.
Bakchoul T, Marini I
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):576-583. doi: 10.1182/asheducation-2018.1.576. PMID: 30504360Free PMC Article
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
Cuker A, Arepally GM, Chong BH, Cines DB, Greinacher A, Gruel Y, Linkins LA, Rodner SB, Selleng S, Warkentin TE, Wex A, Mustafa RA, Morgan RL, Santesso N
Blood Adv 2018 Nov 27;2(22):3360-3392. doi: 10.1182/bloodadvances.2018024489. PMID: 30482768Free PMC Article

Recent systematic reviews

Cardiac transplantation after heparin-induced thrombocytopenia: A systematic review.
Jimenez DC, Warner ED, Ahmad D, Rosen JL, Al-Rawas N, Morris RJ, Alvarez R, Rame JE, Entwistle JW, Massey HT, Tchantchaleishvili V
Clin Transplant 2022 Feb;36(2):e14567. Epub 2022 Jan 6 doi: 10.1111/ctr.14567. PMID: 34927287
COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis.
Bilotta C, Perrone G, Adelfio V, Spatola GF, Uzzo ML, Argo A, Zerbo S
Front Immunol 2021;12:729251. Epub 2021 Nov 29 doi: 10.3389/fimmu.2021.729251. PMID: 34912330Free PMC Article
Comparative effectiveness and safety of anticoagulants for the treatment of heparin-induced thrombocytopenia.
Nilius H, Kaufmann J, Cuker A, Nagler M
Am J Hematol 2021 Jul 1;96(7):805-815. Epub 2021 May 3 doi: 10.1002/ajh.26194. PMID: 33857342Free PMC Article
Prognostic factors for patients with heparin-induced thrombocytopenia: a systematic review.
Colarossi G, Schnöring H, Trivellas A, Betsch M, Hatam N, Eschweiler J, Tingart M, Migliorini F
Int J Clin Pharm 2021 Jun;43(3):449-460. Epub 2020 Oct 12 doi: 10.1007/s11096-020-01166-2. PMID: 33044680
Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis.
Zhong L, Wang HL, Xu B, Yuan Y, Wang X, Zhang YY, Ji L, Pan ZM, Hu ZS
Crit Care 2017 Jan 8;21(1):5. doi: 10.1186/s13054-016-1585-x. PMID: 28063456Free PMC Article

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