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Neonatal alloimmune thrombocytopenia

MedGen UID:
840004
Concept ID:
C3853779
Disease or Syndrome
Synonyms: Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenia; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenia; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenia, Neonatal Alloimmune; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune
SNOMED CT: Neonatal alloimmune thrombocytopenia (240305000); Isoimmune neonatal thrombocytopenia (240305000); Alloimmune neonatal thrombocytopenia (240305000); Neonatal thrombocytopenia due to platelet alloimmunization (240305000); NAIT - neonatal alloimmune thrombocytopenia (240305000)
 
HPO: HP:0004809

Definition

Low platelet count associated with maternal platelet-specific alloantibodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal alloimmune thrombocytopenia

Professional guidelines

PubMed

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Recent clinical studies

Etiology

Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, Fergusson D, Arbous S, Bauer SR, China L, Fung M, Jug R, Neill M, Paine C, Pavenski K, Shah PS, Robinson S, Shan H, Szczepiorkowski ZM, Thevenot T, Wu B, Stanworth S, Shehata N; International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group
Chest 2024 Aug;166(2):321-338. Epub 2024 Mar 4 doi: 10.1016/j.chest.2024.02.049. PMID: 38447639Free PMC Article
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Diagnosis

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Therapy

Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, Fergusson D, Arbous S, Bauer SR, China L, Fung M, Jug R, Neill M, Paine C, Pavenski K, Shah PS, Robinson S, Shan H, Szczepiorkowski ZM, Thevenot T, Wu B, Stanworth S, Shehata N; International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group
Chest 2024 Aug;166(2):321-338. Epub 2024 Mar 4 doi: 10.1016/j.chest.2024.02.049. PMID: 38447639Free PMC Article
Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Oepkes D
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:15-27. Epub 2019 Feb 6 doi: 10.1016/j.bpobgyn.2019.01.017. PMID: 30827816

Prognosis

Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Holzhauer S, Zieger B
Semin Fetal Neonatal Med 2011 Dec;16(6):305-10. Epub 2011 Aug 10 doi: 10.1016/j.siny.2011.07.008. PMID: 21835709
Roberts I, Stanworth S, Murray NA
Blood Rev 2008 Jul;22(4):173-86. Epub 2008 Apr 22 doi: 10.1016/j.blre.2008.03.004. PMID: 18433954
Porcelijn L, Van den Akker ES, Oepkes D
Semin Fetal Neonatal Med 2008 Aug;13(4):223-30. Epub 2008 Apr 8 doi: 10.1016/j.siny.2008.02.008. PMID: 18400574

Clinical prediction guides

Guillet S, Loustau V, Boutin E, Zarour A, Comont T, Souchaud-Debouverie O, Costedoat Chalumeau N, Pan-Petesch B, Gobert D, Cheze S, Viallard JF, Morin AS, Sauvetre G, Cliquennois M, Royer B, Masseau A, Terriou L, Fieschi C, Lambotte O, Girault S, Lioger B, Audia S, Sacre K, Lega JC, Langlois V, Benachi A, Orvain C, Devidas A, Humbert S, Gambier N, Ruivard M, Zarrouk V, Ebbo M, Willems L, Segaux L, Mahevas M, Haddad B, Michel M, Canoui-Poitrine F, Godeau B
Blood 2023 Jan 5;141(1):11-21. doi: 10.1182/blood.2022017277. PMID: 36054922Free PMC Article
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Brojer E, Husebekk A, Dębska M, Uhrynowska M, Guz K, Orzińska A, Dębski R, Maślanka K
Arch Immunol Ther Exp (Warsz) 2016 Aug;64(4):279-90. Epub 2015 Nov 12 doi: 10.1007/s00005-015-0371-9. PMID: 26564154Free PMC Article
Roberts I, Stanworth S, Murray NA
Blood Rev 2008 Jul;22(4):173-86. Epub 2008 Apr 22 doi: 10.1016/j.blre.2008.03.004. PMID: 18433954
Santoso S, Kiefel V
Wien Klin Wochenschr 2001 Oct 30;113(20-21):806-13. PMID: 11732116

Recent systematic reviews

Kjeldsen-Kragh J, Fergusson DA, Kjaer M, Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia HF, Landry D, Shehata N
Blood Adv 2020 Jul 28;4(14):3368-3377. doi: 10.1182/bloodadvances.2020002137. PMID: 32717028Free PMC Article
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G
Blood 2017 Mar 16;129(11):1538-1547. Epub 2017 Jan 27 doi: 10.1182/blood-2016-10-739656. PMID: 28130210
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Bassler D, Greinacher A, Okascharoen C, Klenner A, Ditomasso J, Kiefel V, Chan A, Paes B
Transfusion 2008 Jan;48(1):92-8. Epub 2007 Sep 24 doi: 10.1111/j.1537-2995.2007.01486.x. PMID: 17894790

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