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Neoplasm of the genitourinary tract

MedGen UID:
22583
•Concept ID:
C0042065
•
Neoplastic Process
Synonym: Genitourinary neoplasm
 
Related genes: CHEK2, BCL10, MAD1L1, STK11, RB1, PTEN, PRCC, PIK3CA, PRKN, OPCML, MXI1, MET, KRAS, KIT, HRAS, FGFR3, ERBB2, CTNNB1, KLF6, CDH1, BRCA2, ZFHX3, AR, AKT1
 
HPO: HP:0007379

Definition

A tumor (abnormal growth of tissue) of the genitourinary system. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oaknin A, Bosse TJ, Creutzberg CL, Giornelli G, Harter P, Joly F, Lorusso D, Marth C, Makker V, Mirza MR, Ledermann JA, Colombo N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Sep;33(9):860-877. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.009. PMID: 35690222
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Practice Bulletin No. 174: Evaluation and Management of Adnexal Masses.
American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2016 Nov;128(5):e210-e226. doi: 10.1097/AOG.0000000000001768. PMID: 27776072

Curated

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

Pseudosarcomatous myofibroblastic proliferations of the urinary bladder are neoplasms characterized by recurrent FN1-ALK fusions.
Acosta AM, Demicco EG, Dal Cin P, Hirsch MS, Fletcher CDM, Jo VY
Mod Pathol 2021 Feb;34(2):469-477. Epub 2020 Sep 9 doi: 10.1038/s41379-020-00670-0. PMID: 32908253
DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
Pancaldi A, Peng L, Rhee DS, Dunn E, Forcucci JA, Belchis D, Pratilas CA
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005603. PMID: 33028642Free PMC Article

Diagnosis

Detection and genomic characterization of a mammary-like adenocarcinoma.
Grewal JK, Eirew P, Jones M, Chiu K, Tessier-Cloutier B, Karnezis AN, Karsan A, Mungall A, Zhou C, Yip S, Tinker AV, Laskin J, Marra M, Jones SJM
Cold Spring Harb Mol Case Stud 2017 Nov;3(6) Epub 2017 Nov 21 doi: 10.1101/mcs.a002170. PMID: 28877932Free PMC Article

Therapy

Tumor-immune microenvironment revealed by Imaging Mass Cytometry in a metastatic sarcomatoid urothelial carcinoma with a prolonged response to pembrolizumab.
Alnajar H, Ravichandran H, Figueiredo Rendeiro A, Ohara K, Al Zoughbi W, Manohar J, Greco N, Sigouros M, Fox J, Muth E, Angiuoli S, Faltas B, Shusterman M, Sternberg CN, Elemento O, Mosquera JM
Cold Spring Harb Mol Case Stud 2022 Apr;8(3) Epub 2022 Apr 28 doi: 10.1101/mcs.a006151. PMID: 35483877Free PMC Article

Prognosis

DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.
Pancaldi A, Peng L, Rhee DS, Dunn E, Forcucci JA, Belchis D, Pratilas CA
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005603. PMID: 33028642Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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