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Ovarian cystadenoma

MedGen UID:
138041
•Concept ID:
C0346169
•
Neoplastic Process
Synonyms: Benign Cystadenoma of Ovary; benign cystadenoma of ovary; Benign Cystadenoma of the Ovary; benign cystadenoma of the ovary; Benign Ovarian Cystadenoma; benign ovarian cystadenoma; Cystadenoma of Ovary; cystadenoma of ovary; Cystadenoma of the Ovary; cystadenoma of the ovary; cystoma serosum simplex; Ovarian Cystadenoma; ovarian cystadenoma; ovary cystadenoma; Simple Cystoma of Ovary; simple cystoma of ovary; Simple cystoma of the ovary; simple cystoma of the ovary; simple ovarian cystoma
SNOMED CT: Simple cystoma of the ovary (198297004)
 
HPO: HP:6000672
Monarch Initiative: MONDO:0005183

Definition

A common, benign ovarian tumor that carries a good prognosis. The two most frequent types of cystadenomas are serous and mucinous cystadenomas whereas endometrioid and clear cell cystadenomas are rare. [from HPO]

Professional guidelines

PubMed

Transvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal women.
Guerriero S, Mallarini G, Ajossa S, Risalvato A, Satta R, Mais V, Angiolucci M, Melis GB
Ultrasound Obstet Gynecol 1997 May;9(5):339-43. doi: 10.1046/j.1469-0705.1997.09050339.x. PMID: 9201878

Recent clinical studies

Etiology

Determining the significance of psammoma bodies in pelvic washings: A 10-year retrospective review.
Sun T, Pitman MB, Torous VF
Cancer Cytopathol 2021 Jan;129(1):83-89. Epub 2020 Sep 15 doi: 10.1002/cncy.22346. PMID: 32931128
An association of circulating Tregs and Th17 cells producing IL-21 and IL-22 with the ROMA in ovarian cancer patients.
Winkler I, Woś J, Karczmarczyk A, Miotła P, Gogacz M, Skorupska K, Rechberger T, Tabarkiewicz J, Wolińska E, Skrzypczak M
Cytokine 2020 Oct;134:155194. Epub 2020 Jul 21 doi: 10.1016/j.cyto.2020.155194. PMID: 32707423
Proceedings of the 2019 National Toxicology Program Satellite Symposium.
Elmore SA, Cesta MF, Crabbs TA, Janardhan KS, Krane GA, Mahapatra D, Quist EM, Rinke M, Schaaf GW, Travlos GS, Wang H, Willson CJ, Wolf JC
Toxicol Pathol 2019 Dec;47(8):913-953. Epub 2019 Oct 23 doi: 10.1177/0192623319876929. PMID: 31645210Free PMC Article
Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic?
Carrasco-Juan JL, Álvarez-Argüelles-Cabrera H, Martín-Corriente C, Gutiérrez-García R, Vega-Falcón A, Expósito-Afonso I, Méndez-Medina R, Díaz-Flores L
Arch Gynecol Obstet 2018 Sep;298(3):655-661. Epub 2018 Jul 3 doi: 10.1007/s00404-018-4846-x. PMID: 29971558
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.
Huang Y, Jin H, Liu Y, Zhou J, Ding J, Cheng KW, Yu Y, Feng Y
Endocr Relat Cancer 2011 Feb;18(1):13-26. Epub 2010 Nov 30 doi: 10.1677/ERC-09-0308. PMID: 20943720

Diagnosis

Correlation between plasma PSGL-1 and FIGO stage, tumor metastasis, and survival in epithelial ovarian cancer.
Li W, Fang C, Gao Y, Gao Y, Yan F, Chen B, Xu M
Biotechnol Appl Biochem 2024 Aug;71(4):733-740. Epub 2024 Mar 17 doi: 10.1002/bab.2572. PMID: 38494670
Two-Port Laparoscopic Removal of Large Ovarian Cystadenoma.
Marchand GJ, Sainz K, Ruther S, Azadi A, Ware K, Brazil G, King A, Vallejo J, Cieminski K, Galitsky A, Ulibarri H, Calteux N, Osipov R
J Obstet Gynaecol Can 2022 Aug;44(8):924-925.e1. Epub 2021 Feb 23 doi: 10.1016/j.jogc.2021.01.020. PMID: 33631322
Determining the significance of psammoma bodies in pelvic washings: A 10-year retrospective review.
Sun T, Pitman MB, Torous VF
Cancer Cytopathol 2021 Jan;129(1):83-89. Epub 2020 Sep 15 doi: 10.1002/cncy.22346. PMID: 32931128
Proceedings of the 2019 National Toxicology Program Satellite Symposium.
Elmore SA, Cesta MF, Crabbs TA, Janardhan KS, Krane GA, Mahapatra D, Quist EM, Rinke M, Schaaf GW, Travlos GS, Wang H, Willson CJ, Wolf JC
Toxicol Pathol 2019 Dec;47(8):913-953. Epub 2019 Oct 23 doi: 10.1177/0192623319876929. PMID: 31645210Free PMC Article
A Giant Ovarian Cyst in an Adolescent.
Corrias F, Pederiva F, Cozzi G, Ammar L, Cattaruzzi E, Lembo MA, Barbi E
J Pediatr 2018 Aug;199:279. Epub 2018 May 3 doi: 10.1016/j.jpeds.2018.03.015. PMID: 29731358

Therapy

Exosomal microRNAs as tumor markers in epithelial ovarian cancer.
Pan C, Stevic I, Müller V, Ni Q, Oliveira-Ferrer L, Pantel K, Schwarzenbach H
Mol Oncol 2018 Nov;12(11):1935-1948. Epub 2018 Oct 9 doi: 10.1002/1878-0261.12371. PMID: 30107086Free PMC Article
Pseudomixoma peritonei, a rare entity difficult to diagnose and treat - case report.
Mavrodin C, Pariza G, Iordache V, Iorga P, Sajin M
Chirurgia (Bucur) 2014 Nov-Dec;109(6):846-9. PMID: 25560512
Lower extremity paralysis after operative laparoscopy from conversion disorder. A case report.
Berhane L, Kurman R, Smith S
J Reprod Med 1998 Sep;43(9):831-5. PMID: 9777625

Prognosis

Correlation between plasma PSGL-1 and FIGO stage, tumor metastasis, and survival in epithelial ovarian cancer.
Li W, Fang C, Gao Y, Gao Y, Yan F, Chen B, Xu M
Biotechnol Appl Biochem 2024 Aug;71(4):733-740. Epub 2024 Mar 17 doi: 10.1002/bab.2572. PMID: 38494670
Intraoperative predictors of appendiceal abnormalities in patients with mucinous ovarian neoplasms.
Lavecchia M, Dubey A, Jimenez W, Reade CJ, Salehi A, Yang I, Eiriksson LR
Int J Gynaecol Obstet 2024 Jan;164(1):249-254. Epub 2023 Jul 24 doi: 10.1002/ijgo.15008. PMID: 37485684
Exosomal microRNAs as tumor markers in epithelial ovarian cancer.
Pan C, Stevic I, Müller V, Ni Q, Oliveira-Ferrer L, Pantel K, Schwarzenbach H
Mol Oncol 2018 Nov;12(11):1935-1948. Epub 2018 Oct 9 doi: 10.1002/1878-0261.12371. PMID: 30107086Free PMC Article
Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer.
Li P, Liu K, Li L, Yang M, Gao W, Feng J, Lv Y, Qu X, Kong B
Int J Gynecol Cancer 2011 Oct;21(7):1248-55. doi: 10.1097/IGC.0b013e3182259c31. PMID: 21841490
The expression and significance of Dickkopf-1 in epithelial ovarian carcinoma.
Shizhuo W, Tao J, Shulan Z, Bing Z
Int J Biol Markers 2009 Jul-Sep;24(3):165-70. doi: 10.1177/172460080902400306. PMID: 19787627

Clinical prediction guides

Intraoperative predictors of appendiceal abnormalities in patients with mucinous ovarian neoplasms.
Lavecchia M, Dubey A, Jimenez W, Reade CJ, Salehi A, Yang I, Eiriksson LR
Int J Gynaecol Obstet 2024 Jan;164(1):249-254. Epub 2023 Jul 24 doi: 10.1002/ijgo.15008. PMID: 37485684
An association of circulating Tregs and Th17 cells producing IL-21 and IL-22 with the ROMA in ovarian cancer patients.
Winkler I, Woś J, Karczmarczyk A, Miotła P, Gogacz M, Skorupska K, Rechberger T, Tabarkiewicz J, Wolińska E, Skrzypczak M
Cytokine 2020 Oct;134:155194. Epub 2020 Jul 21 doi: 10.1016/j.cyto.2020.155194. PMID: 32707423
Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic?
Carrasco-Juan JL, Álvarez-Argüelles-Cabrera H, Martín-Corriente C, Gutiérrez-García R, Vega-Falcón A, Expósito-Afonso I, Méndez-Medina R, Díaz-Flores L
Arch Gynecol Obstet 2018 Sep;298(3):655-661. Epub 2018 Jul 3 doi: 10.1007/s00404-018-4846-x. PMID: 29971558
An unexpected death due to massive ascites and a giant mucinous ovarian cystadenoma.
Kashiwagi M, Takayama M, Sugimura T, Matsusue A, Hara K, Waters B, Kubo SI
Leg Med (Tokyo) 2016 Nov;23:1-4. Epub 2016 Aug 26 doi: 10.1016/j.legalmed.2016.08.008. PMID: 27890095
Flow cytometric analysis and cytopathology of body cavity fluids.
Stonesifer KJ, Xiang JH, Wilkinson EJ, Benson NA, Braylan RC
Acta Cytol 1987 Mar-Apr;31(2):125-30. PMID: 3469844

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