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OPCML opioid binding protein/cell adhesion molecule like [ Homo sapiens (human) ]

Gene ID: 4978, updated on 3-Apr-2024

Summary

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Official Symbol
OPCMLprovided by HGNC
Official Full Name
opioid binding protein/cell adhesion molecule likeprovided by HGNC
Primary source
HGNC:HGNC:8143
See related
Ensembl:ENSG00000183715 MIM:600632; AllianceGenome:HGNC:8143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPCM; OBCAM; IGLON1
Summary
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Biased expression in brain (RPKM 9.6) and kidney (RPKM 0.2) See more
Orthologs
mouse all
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Genomic context

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See OPCML in Genome Data Viewer
Location:
11q25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (132414981..133532501, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (132453523..133574050, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (132284875..133402396, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene neurotrimin Neighboring gene uncharacterized LOC124902795 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:131958013-131959212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5761 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:131992888-131993886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132115578-132116078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132154202-132154771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132154772-132155340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5764 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132188093-132189292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132199915-132200414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132204500-132205000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5765 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:132324306-132324486 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132340747-132341946 Neighboring gene NTM intronic transcript Neighboring gene uncharacterized LOC124902819 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:132483305-132484504 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132502505-132503704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132513245-132513744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132551286-132551786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132551787-132552287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132755960-132756466 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:132780259-132781458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132789928-132790505 Neighboring gene uncharacterized LOC105369580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132930114-132930614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132934609-132935182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4085 Neighboring gene Sharpr-MPRA regulatory region 13378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133085747-133086246 Neighboring gene uncharacterized LOC124902796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133207744-133208254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133230716-133231216 Neighboring gene MPRA-validated peak1519 silencer Neighboring gene Sharpr-MPRA regulatory region 13397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4086 Neighboring gene small nucleolar RNA U13 Neighboring gene OPCML intronic transcript 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:133367412-133367912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:133367913-133368413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133378571-133379070 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:133380000-133380899 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133411065-133411636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133415514-133416432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133424165-133424756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133424757-133425347 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:133440092-133441291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133498537-133499043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133499044-133499549 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133511071-133511692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133590113-133591005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133600941-133601440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133616212-133617180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133657715-133658245 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:133672578-133673777 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:133678028-133678694 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133678695-133679361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:133679362-133680028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:133712096-133712638 Neighboring gene long intergenic non-protein coding RNA 2743 Neighboring gene spermatogenesis associated 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation. Khamko R, et al. Cancer Genomics Proteomics, 2021 Nov-Dec. PMID 34697068, Free PMC Article
  2. Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer. Lian B, et al. Breast Cancer, 2021 Mar. PMID 33108608
  3. Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers. Antony J, et al. Cancer Gene Ther, 2021 Feb. PMID 32595215
  4. OPCML: A Promising Biomarker and Therapeutic Avenue. Simovic I, et al. Trends Cancer, 2019 Aug. PMID 31421903
  5. Epigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation. Singh V, et al. J Cancer Res Ther, 2019 Jan-Mar. PMID 30880778

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
    Title: Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
  2. OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
    Title: OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
  3. Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.
    Title: Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.
  4. Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer.
    Title: Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer.
  5. LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML.
    Title: LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML.
  6. The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.
    Title: The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.
  7. Human opioid-binding protein/cell adhesion molecule (OPCML) is expressed in many tissues and localizes to the plasma membrane. It is a putative tumor suppressor that acts on receptor tyrosine kinases, influencing cell cycle arrest, apoptosis, and migration. Its expression is silenced epigenetically in cancer, inferring potential diagnostic, prognostic, and therapeutic roles. [Review]
    Title: OPCML: A Promising Biomarker and Therapeutic Avenue.
  8. OPCML promoter was found to be hypermethylated in esophageal squamous cell carcinoma (ESCC) samples. Hypermethylation of the studied OPCML promoter produced no effect on OPCML protein expression in Grade 2 tumors but revealed downregulation in Grade 3 tumors. Deranged OPCML expression may lead to high-grade ESCC as well as epigenetically regulated genes that may alter the Wnt/beta-catenin and TGF-beta-Smad pathways in ...
    Title: Epigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation.
  9. OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling.
    Title: The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
  10. Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines
    Title: The Tumor-Suppressor Protein OPCML Potentiates Anti-EGFR- and Anti-HER2-Targeted Therapy in HER2-Positive Ovarian and Breast Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
EBI GWAS Catalog
Genome-wide association of sleep and circadian phenotypes.
EBI GWAS Catalog
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron recognition TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
opioid-binding protein/cell adhesion molecule
Names
IgLON family member 1
opioid binding protein/cell adhesion molecule-like preprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012107.2 RefSeqGene

    Range
    5000..1122520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012393.5 → NP_001012393.1  opioid-binding protein/cell adhesion molecule isoform b precursor

    See identical proteins and their annotated locations for NP_001012393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (b) is shorter and has a distinct N-terminus compared to isoform c. The encoded isoform (b) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AP000843, AP000863, AP004606, AP005122
    Consensus CDS
    CCDS31722.1
    UniProtKB/TrEMBL
    B4DS15
    Related
    ENSP00000434750.1, ENST00000524381.6
    Conserved Domains (3) summary
    smart00408
    Location:142 → 199
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:227 → 305
    IG; Immunoglobulin
    cl11960
    Location:37 → 125
    Ig; Immunoglobulin domain

  2. NM_001319103.2 → NP_001306032.1  opioid-binding protein/cell adhesion molecule isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c). The encoded isoform (c) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AK314077, AP000843, AP005122, BC143946, DA247864
    UniProtKB/TrEMBL
    Q6B0I4
    Related
    ENSP00000445496.1, ENST00000541867.6
    Conserved Domains (3) summary
    pfam13927
    Location:135 → 206
    Ig_3; Immunoglobulin domain
    cd00096
    Location:224 → 230
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:224 → 312
    Ig; Immunoglobulin domain

  3. NM_001319104.4 → NP_001306033.1  opioid-binding protein/cell adhesion molecule isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (d) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AP000843, BC143946, BX537377, DA247864, DC332150, EU562298
    UniProtKB/TrEMBL
    B0AZR8, B2CZX3
    Conserved Domains (3) summary
    smart00409
    Location:2 → 32
    IG; Immunoglobulin
    smart00410
    Location:134 → 212
    IG_like; Immunoglobulin like
    pfam13927
    Location:35 → 106
    Ig_3; Immunoglobulin domain

  4. NM_001319105.2 → NP_001306034.1  opioid-binding protein/cell adhesion molecule isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream translation start site, and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (e) is shorter and lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AK316491, AP000843, AP005122, BC143946, DA247864
    Consensus CDS
    CCDS81649.1
    UniProtKB/TrEMBL
    Q6B0I4
    Related
    ENSP00000363910.4, ENST00000374778.4
    Conserved Domains (3) summary
    cd00096
    Location:199 → 203
    Ig; Ig strand B [structural motif]
    pfam13927
    Location:94 → 165
    Ig_3; Immunoglobulin domain
    cl11960
    Location:183 → 271
    Ig; Immunoglobulin domain

  5. NM_001319106.2 → NP_001306035.1  opioid-binding protein/cell adhesion molecule isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (f) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AK314077, AP000843, AP005122, BC143946, BX537377, DA247864
    UniProtKB/TrEMBL
    B7ZLQ0, Q6B0I4
    Conserved Domains (3) summary
    smart00408
    Location:149 → 205
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:233 → 311
    IG; Immunoglobulin
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain

  6. NM_002545.5 → NP_002536.1  opioid-binding protein/cell adhesion molecule isoform a preproprotein

    See identical proteins and their annotated locations for NP_002536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The encoded isoform (a) is shorter than isoform c.
    Source sequence(s)
    AK314077, AP000843, AP005122, BC143946, BX537377, DA247864, L34774
    Consensus CDS
    CCDS8492.1
    UniProtKB/Swiss-Prot
    B2CZX2, B7ZLQ1, Q14982, Q17RN7, Q7Z3W6
    UniProtKB/TrEMBL
    A8K0Y0, Q6B0I4
    Related
    ENSP00000330862.7, ENST00000331898.11
    Conserved Domains (3) summary
    smart00408
    Location:149 → 206
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:234 → 312
    IG; Immunoglobulin
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    132414981..133532501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718846.4 → XP_006718909.1  opioid-binding protein/cell adhesion molecule isoform X1

    See identical proteins and their annotated locations for XP_006718909.1

    UniProtKB/TrEMBL
    B4DS15
    Conserved Domains (4) summary
    smart00408
    Location:142 → 198
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:226 → 304
    IG_like; Immunoglobulin like
    pfam00047
    Location:222 → 303
    ig; Immunoglobulin domain
    cl11960
    Location:37 → 125
    Ig; Immunoglobulin domain

  2. XM_047427032.1 → XP_047282988.1  opioid-binding protein/cell adhesion molecule isoform X2

    Conserved Domains (3) summary
    cd00096
    Location:199 → 203
    Ig; Ig strand B [structural motif]
    pfam13927
    Location:94 → 165
    Ig_3; Immunoglobulin domain
    cl11960
    Location:183 → 271
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    132453523..133574050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368974.1 → XP_054224949.1  opioid-binding protein/cell adhesion molecule isoform X1

  2. XM_054368975.1 → XP_054224950.1  opioid-binding protein/cell adhesion molecule isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14982.1 GenPept UniProtKB/Swiss-Prot:Q14982

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