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Vaginal squamous tumor

MedGen UID:
274381
•Concept ID:
C1519931
•
Neoplastic Process
Synonyms: vagina squamous cell neoplasm; Vaginal Squamous Neoplasm; vaginal squamous neoplasm; Vaginal Squamous Tumor; vaginal squamous tumor
 
Monarch Initiative: MONDO:0001806

Definition

A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vagina. [from NCI]

Professional guidelines

PubMed

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071

Recent clinical studies

Etiology

Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort.
Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z, Di W, Qiu L
BMC Infect Dis 2020 Aug 26;20(1):629. doi: 10.1186/s12879-020-05324-9. PMID: 32842982Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Cervical cancer.
Shepherd JH
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):293-309. Epub 2012 Feb 19 doi: 10.1016/j.bpobgyn.2011.12.004. PMID: 22353492

Diagnosis

Squamous and Glandular Lesions of the Vulva and Vagina: What's New and What Remains Unanswered?
Wei KX, Hoang LN
Surg Pathol Clin 2022 Jun;15(2):389-405. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.011. PMID: 35715167
Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318

Therapy

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Prevention of Human Papillomavirus Infection. Beyond Cervical Cancer: A Brief Review.
Medeiros R, Vaz S, Rebelo T, Figueiredo-Dias M
Acta Med Port 2020 Mar 2;33(3):198-201. doi: 10.20344/amp.12259. PMID: 32130098
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Prevention of cervix cancer.
Rock CL, Michael CW, Reynolds RK, Ruffin MT
Crit Rev Oncol Hematol 2000 Mar;33(3):169-85. doi: 10.1016/s1040-8428(99)00073-6. PMID: 10789491

Prognosis

Genital diseases in the mature woman.
Matthews N, Wong V, Brooks J, Kroumpouzos G
Clin Dermatol 2018 Mar-Apr;36(2):208-221. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.012. PMID: 29566925
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Management of advanced primary urethral carcinomas.
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439
Vulvar and vaginal cancer.
Carter JS, Downs LS Jr
Obstet Gynecol Clin North Am 2012 Jun;39(2):213-31. doi: 10.1016/j.ogc.2012.04.002. PMID: 22640712

Clinical prediction guides

Characteristics of the vaginal microbiota and vaginal metabolites in women with cervical dysplasia.
Yu T, Gao S, Jin F, Yan B, Wang W, Wang Z
Front Cell Infect Microbiol 2024;14:1457216. Epub 2024 Oct 10 doi: 10.3389/fcimb.2024.1457216. PMID: 39450338Free PMC Article
Genital and extragenital oncological risk in women with vulvar lichen sclerosus: A multi-center Italian study.
Preti M, Borella F, Ferretti S, Caldarella A, Corazza M, Micheletti L, De Magnis A, Borghi A, Salvini C, Gallio N, Pasquero G, Vieira-Baptista P, Selk A, Benedetto C, Rosso S
Maturitas 2023 Sep;175:107767. Epub 2023 May 3 doi: 10.1016/j.maturitas.2023.04.010. PMID: 37302181
Microbiota unbalance in relation to high-risk human papillomavirus cervical infection.
Gomez Cherey JF, Payalef SN, Fleider L, Reyes AP, Maldonado VA, Losada MO, Chen X, Cardinal LH, Wang Y, Tatti SA, Perazzi BE
Int J Gynecol Cancer 2023 Apr 3;33(4):482-488. doi: 10.1136/ijgc-2022-003760. PMID: 36604120
Clinical and morphopathological assay in vulvovaginal candidiasis.
Manolea MM, Istrate-Ofiţeru AM, Săndulescu MS, Camen IV, Piciu IA, Dijmărescu AL, Vrabie SC, Neamţu SD, Obleagă CV, Siminel MA
Rom J Morphol Embryol 2022 Jul-Sep;63(3):511-520. doi: 10.47162/RJME.63.3.05. PMID: 36588489Free PMC Article
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article

Recent systematic reviews

Efficacy of photodynamic therapy in women with HSIL, LSIL and early stage squamous cervical cancer: a systematic review and meta-analysis.
Unanyan A, Pivazyan L, Davydova J, Murvatova K, Khrapkova A, Movsisyan R, Ishchenko A, Ishchenko A
Photodiagnosis Photodyn Ther 2021 Dec;36:102530. Epub 2021 Sep 14 doi: 10.1016/j.pdpdt.2021.102530. PMID: 34534688
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article
Atypical glandular cells and cervical cancer: systematic review.
Marques JP, Costa LB, Pinto AP, Lima AF, Duarte ME, Barbosa AP, Medeiros PL
Rev Assoc Med Bras (1992) 2011 Mar-Apr;57(2):234-8. doi: 10.1590/s0104-42302011000200024. PMID: 21537713

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