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Endometrioid Tumor, Variant with Squamous Differentiation

MedGen UID:
1697777
•Concept ID:
C5203822
•
Neoplastic Process

Definition

An endometrioid tumor exhibiting squamous differentiation. [from NCI]

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Recent clinical studies

Etiology

Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Pulmonary adenocarcinoma: the expanding spectrum of histologic variants.
Moran CA
Arch Pathol Lab Med 2006 Jul;130(7):958-62. doi: 10.5858/2006-130-958-PATESO. PMID: 16831050
Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed.
Young RH, Clement PB
Semin Diagn Pathol 1995 Feb;12(1):14-29. PMID: 7770671

Diagnosis

Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Prognosis

Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type.
Silva EG, Young RH
Am J Surg Pathol 2007 Aug;31(8):1203-8. doi: 10.1097/PAS.0b013e3180339ed7. PMID: 17667544
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Kuragaki C, Enomoto T, Ueno Y, Sun H, Fujita M, Nakashima R, Ueda Y, Wada H, Murata Y, Toki T, Konishi I, Fujii S
Lab Invest 2003 Jan;83(1):35-45. doi: 10.1097/01.lab.0000049821.16698.d0. PMID: 12533684
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

Clinical prediction guides

Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
Katoh T, Yasuda M, Hasegawa K, Kozawa E, Maniwa J, Sasano H
Diagn Pathol 2012 Nov 28;7:164. doi: 10.1186/1746-1596-7-164. PMID: 23190574Free PMC Article
CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker.
Hoshimoto K, Yamauchi N, Takazawa Y, Onda T, Taketani Y, Fukayama M
Pathol Res Pract 2003;199(2):71-7. doi: 10.1078/0344-0338-00357. PMID: 12747468
Early invasive adenocarcinoma of the cervix.
Lee KR, Flynn CE
Cancer 2000 Sep 1;89(5):1048-55. PMID: 10964335
Sertoliform endometrial adenocarcinoma: a study of four cases.
Eichhorn JH, Young RH, Clement PB
Int J Gynecol Pathol 1996 Apr;15(2):119-26. doi: 10.1097/00004347-199604000-00005. PMID: 8786200
Ovarian endometrioid tumors mimicking Sertoli and Sertoli-Leydig cell tumors: Sertoliform variant of endometrioid carcinoma.
Roth LM, Liban E, Czernobilsky B
Cancer 1982 Oct 1;50(7):1322-31. doi: 10.1002/1097-0142(19821001)50:7<1322::aid-cncr2820500718>3.0.co;2-c. PMID: 7104975

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