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Adverse Event

MedGen UID:
209094
Concept ID:
C0877248
Pathologic Function
Synonym: Adverse Experience

Definition

Any unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical treatment or procedure, and that may or may not be considered related to the medical treatment or procedure. Such events can be related to the intervention, dose, route of administration, patient, or caused by an interaction with another drug(s) or procedure(s). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdverse Event

Professional guidelines

PubMed

Freund Y, Viglino D, Cachanado M, Cassard C, Montassier E, Douay B, Guenezan J, Le Borgne P, Yordanov Y, Severin A, Roussel M, Daniel M, Marteau A, Peschanski N, Teissandier D, Macrez R, Morere J, Chouihed T, Roux D, Adnet F, Bloom B, Chauvin A, Simon T
JAMA 2023 Dec 19;330(23):2267-2274. doi: 10.1001/jama.2023.24391. PMID: 38019968Free PMC Article
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
Darnell EP, Mooradian MJ, Baruch EN, Yilmaz M, Reynolds KL
Curr Oncol Rep 2020 Mar 21;22(4):39. doi: 10.1007/s11912-020-0897-9. PMID: 32200442

Recent clinical studies

Etiology

Li T, Hu K, Ye L, Ma J, Huang L, Guo C, Huang X, Jiang J, Xie X, Guo C, He Q
J Atheroscler Thromb 2024 Apr 1;31(4):396-418. Epub 2023 Nov 30 doi: 10.5551/jat.64461. PMID: 38030236Free PMC Article
Kim AY, Marduy A, de Melo PS, Gianlorenco AC, Kim CK, Choi H, Song JJ, Fregni F
Sci Rep 2022 Dec 21;12(1):22055. doi: 10.1038/s41598-022-25864-1. PMID: 36543841Free PMC Article
Hwang SR, Saliba AN, Wolanskyj-Spinner AP
Hematol Oncol Clin North Am 2022 Apr;36(2):365-380. doi: 10.1016/j.hoc.2021.11.002. PMID: 35339260
Pogue JM, Tam VH
Adv Exp Med Biol 2019;1145:289-304. doi: 10.1007/978-3-030-16373-0_17. PMID: 31364083
Els C, Jackson TD, Kunyk D, Lappi VG, Sonnenberg B, Hagtvedt R, Sharma S, Kolahdooz F, Straube S
Cochrane Database Syst Rev 2017 Oct 30;10(10):CD012509. doi: 10.1002/14651858.CD012509.pub2. PMID: 29084357Free PMC Article

Diagnosis

Chen Y, Fan Q, Liu Y, Shi Y, Luo H
Psychiatry Res 2023 Aug;326:115300. Epub 2023 Jun 22 doi: 10.1016/j.psychres.2023.115300. PMID: 37364503
Guo M, Shu Y, Chen G, Li J, Li F
Sci Rep 2022 Nov 29;12(1):20601. doi: 10.1038/s41598-022-23726-4. PMID: 36446798Free PMC Article
Hwang SR, Saliba AN, Wolanskyj-Spinner AP
Hematol Oncol Clin North Am 2022 Apr;36(2):365-380. doi: 10.1016/j.hoc.2021.11.002. PMID: 35339260
Jo CE, Finstad A, Georgakopoulos JR, Piguet V, Yeung J, Drucker AM
J Am Acad Dermatol 2021 May;84(5):1339-1347. Epub 2021 Jan 8 doi: 10.1016/j.jaad.2021.01.012. PMID: 33428978
Jayne DR, Gaskin G, Rasmussen N, Abramowicz D, Ferrario F, Guillevin L, Mirapeix E, Savage CO, Sinico RA, Stegeman CA, Westman KW, van der Woude FJ, de Lind van Wijngaarden RA, Pusey CD; European Vasculitis Study Group
J Am Soc Nephrol 2007 Jul;18(7):2180-8. Epub 2007 Jun 20 doi: 10.1681/ASN.2007010090. PMID: 17582159

Therapy

Thurber KM, Otto AO, Stricker SL
Am J Health Syst Pharm 2023 Apr 8;80(8):487-494. doi: 10.1093/ajhp/zxad009. PMID: 36629265
Spring LM, Nakajima E, Hutchinson J, Viscosi E, Blouin G, Weekes C, Rugo H, Moy B, Bardia A
Oncologist 2021 Oct;26(10):827-834. Epub 2021 Jul 10 doi: 10.1002/onco.13878. PMID: 34176192Free PMC Article
Avgerinos KI, Ferrucci L, Kapogiannis D
Ageing Res Rev 2021 Jul;68:101339. Epub 2021 Apr 5 doi: 10.1016/j.arr.2021.101339. PMID: 33831607Free PMC Article
Martimbianco ALC, Torloni MR, Andriolo BN, Porfírio GJ, Riera R
Cochrane Database Syst Rev 2017 Dec 12;12(12):CD011289. doi: 10.1002/14651858.CD011289.pub2. PMID: 29231243Free PMC Article
Page MJ, Green S, Kramer S, Johnston RV, McBain B, Buchbinder R
Cochrane Database Syst Rev 2014 Oct 1;2014(10):CD011324. doi: 10.1002/14651858.CD011324. PMID: 25271097Free PMC Article

Prognosis

O'Malley DM, Bariani GM, Cassier PA, Marabelle A, Hansen AR, De Jesus Acosta A, Miller WH Jr, Safra T, Italiano A, Mileshkin L, Xu L, Jin F, Norwood K, Maio M
J Clin Oncol 2022 Mar 1;40(7):752-761. Epub 2022 Jan 6 doi: 10.1200/JCO.21.01874. PMID: 34990208Free PMC Article
Thomas SJ, Moreira ED Jr, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Polack FP, Zerbini C, Bailey R, Swanson KA, Xu X, Roychoudhury S, Koury K, Bouguermouh S, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Yang Q, Liberator P, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Gruber WC, Jansen KU; C4591001 Clinical Trial Group
N Engl J Med 2021 Nov 4;385(19):1761-1773. Epub 2021 Sep 15 doi: 10.1056/NEJMoa2110345. PMID: 34525277Free PMC Article
Bastidas A, de la Serna J, El Idrissi M, Oostvogels L, Quittet P, López-Jiménez J, Vural F, Pohlreich D, Zuckerman T, Issa NC, Gaidano G, Lee JJ, Abhyankar S, Solano C, Perez de Oteyza J, Satlin MJ, Schwartz S, Campins M, Rocci A, Vallejo Llamas C, Lee DG, Tan SM, Johnston AM, Grigg A, Boeckh MJ, Campora L, Lopez-Fauqued M, Heineman TC, Stadtmauer EA, Sullivan KM; ZOE-HSCT Study Group Collaborators
JAMA 2019 Jul 9;322(2):123-133. doi: 10.1001/jama.2019.9053. PMID: 31287523Free PMC Article
Kim SY, Kim HS, Park HJ
World J Gastroenterol 2019 Jan 14;25(2):190-204. doi: 10.3748/wjg.v25.i2.190. PMID: 30670909Free PMC Article
Vancheri C, Kreuter M, Richeldi L, Ryerson CJ, Valeyre D, Grutters JC, Wiebe S, Stansen W, Quaresma M, Stowasser S, Wuyts WA; INJOURNEY Trial Investigators
Am J Respir Crit Care Med 2018 Feb 1;197(3):356-363. doi: 10.1164/rccm.201706-1301OC. PMID: 28889759

Clinical prediction guides

De Potter T, Grimaldi M, Duytschaever M, Anic A, Vijgen J, Neuzil P, Van Herendael H, Verma A, Skanes A, Scherr D, Pürerfellner H, Rackauskas G, Jais P, Reddy VY; inspIRE Trial Investigators
Circ Arrhythm Electrophysiol 2024 May;17(5):e012667. Epub 2024 Apr 24 doi: 10.1161/CIRCEP.123.012667. PMID: 38655693Free PMC Article
Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, Jonas J, Li S, Sankoh AJ, Silber C, Campbell AD, Werneburg B, Kanes SJ, Lasser R
JAMA Psychiatry 2021 Sep 1;78(9):951-959. doi: 10.1001/jamapsychiatry.2021.1559. PMID: 34190962Free PMC Article
Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A
Gut 2021 Mar;70(3):476-484. Epub 2020 Jun 4 doi: 10.1136/gutjnl-2019-319926. PMID: 32499390Free PMC Article
Khanna AK, Bergese SD, Jungquist CR, Morimatsu H, Uezono S, Lee S, Ti LK, Urman RD, McIntyre R Jr, Tornero C, Dahan A, Saager L, Weingarten TN, Wittmann M, Auckley D, Brazzi L, Le Guen M, Soto R, Schramm F, Ayad S, Kaw R, Di Stefano P, Sessler DI, Uribe A, Moll V, Dempsey SJ, Buhre W, Overdyk FJ; PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) Group Collaborators
Anesth Analg 2020 Oct;131(4):1012-1024. doi: 10.1213/ANE.0000000000004788. PMID: 32925318Free PMC Article
Tharp MD, Bernstein JA, Kavati A, Ortiz B, MacDonald K, Denhaerynck K, Abraham I, Lee CS
JAMA Dermatol 2019 Jan 1;155(1):29-38. doi: 10.1001/jamadermatol.2018.3447. PMID: 30427977Free PMC Article

Recent systematic reviews

Puyana C, Chandan N, Tsoukas M
J Cosmet Dermatol 2022 Dec;21(12):6636-6643. Epub 2022 Oct 31 doi: 10.1111/jocd.15420. PMID: 36176207
Avgerinos KI, Ferrucci L, Kapogiannis D
Ageing Res Rev 2021 Jul;68:101339. Epub 2021 Apr 5 doi: 10.1016/j.arr.2021.101339. PMID: 33831607Free PMC Article
Tan CSS, Lee SWH
Br J Clin Pharmacol 2021 Feb;87(2):352-374. Epub 2020 Jul 1 doi: 10.1111/bcp.14404. PMID: 32478963
Wang Y, Zhou S, Yang F, Qi X, Wang X, Guan X, Shen C, Duma N, Vera Aguilera J, Chintakuntlawar A, Price KA, Molina JR, Pagliaro LC, Halfdanarson TR, Grothey A, Markovic SN, Nowakowski GS, Ansell SM, Wang ML
JAMA Oncol 2019 Jul 1;5(7):1008-1019. doi: 10.1001/jamaoncol.2019.0393. PMID: 31021376Free PMC Article
Müller M, Jürgens J, Redaèlli M, Klingberg K, Hautz WE, Stock S
BMJ Open 2018 Aug 23;8(8):e022202. doi: 10.1136/bmjopen-2018-022202. PMID: 30139905Free PMC Article

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