U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neonatal Respiratory Insufficiency, AE

MedGen UID:
1660442
•Concept ID:
C4743806
•
Finding
Synonym: Neonatal Respiratory Insufficiency, Adverse Event

Definition

An adverse event in a newborn characterized by significant impairment of gas exchange resulting in compensatory breathing efforts and eventually hypoxia and/or hypercarbia. Note: Consider this adverse event for any patient whose respiratory condition deteriorates from baseline. If any specific diagnosis is identified: use diagnosis-specific scale (e.g. respiratory distress syndrome (RDS), pulmonary hemorrhage). [from NCI]

Professional guidelines

PubMed

Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia.
Bauchat JR, Weiniger CF, Sultan P, Habib AS, Ando K, Kowalczyk JJ, Kato R, George RB, Palmer CM, Carvalho B
Anesth Analg 2019 Aug;129(2):458-474. doi: 10.1213/ANE.0000000000004195. PMID: 31082964
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144

Recent clinical studies

Etiology

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants.
Lemyre B, Deguise MO, Benson P, Kirpalani H, Ekhaguere OA, Davis PG
Cochrane Database Syst Rev 2023 Jul 19;7(7):CD005384. doi: 10.1002/14651858.CD005384.pub3. PMID: 37466143Free PMC Article
High-frequency ventilation in preterm infants and neonates.
Ackermann BW, Klotz D, Hentschel R, Thome UH, van Kaam AH
Pediatr Res 2023 Jun;93(7):1810-1818. Epub 2022 Feb 8 doi: 10.1038/s41390-021-01639-8. PMID: 35136198Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia.
Bauchat JR, Weiniger CF, Sultan P, Habib AS, Ando K, Kowalczyk JJ, Kato R, George RB, Palmer CM, Carvalho B
Anesth Analg 2019 Aug;129(2):458-474. doi: 10.1213/ANE.0000000000004195. PMID: 31082964
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905

Diagnosis

Pediatric vascular anomalies with airway compromise.
Gorostidi F, Glasson N, Salati V, Sandu K
J Oral Pathol Med 2022 Nov;51(10):888-896. Epub 2022 Apr 6 doi: 10.1111/jop.13297. PMID: 35347777Free PMC Article
Robin Sequence: Neonatal Mandibular Distraction.
Morrison KA, Collares MV, Flores RL
Clin Plast Surg 2021 Jul;48(3):363-373. Epub 2021 May 8 doi: 10.1016/j.cps.2021.03.005. PMID: 34051891
Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia.
Bauchat JR, Weiniger CF, Sultan P, Habib AS, Ando K, Kowalczyk JJ, Kato R, George RB, Palmer CM, Carvalho B
Anesth Analg 2019 Aug;129(2):458-474. doi: 10.1213/ANE.0000000000004195. PMID: 31082964
Tracheomalacia.
Wright CD
Chest Surg Clin N Am 2003 May;13(2):349-57, viii. doi: 10.1016/s1052-3359(03)00036-x. PMID: 12755319
Naloxone.
Handal KA, Schauben JL, Salamone FR
Ann Emerg Med 1983 Jul;12(7):438-45. doi: 10.1016/s0196-0644(83)80343-6. PMID: 6309038

Therapy

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants.
Lemyre B, Deguise MO, Benson P, Kirpalani H, Ekhaguere OA, Davis PG
Cochrane Database Syst Rev 2023 Jul 19;7(7):CD005384. doi: 10.1002/14651858.CD005384.pub3. PMID: 37466143Free PMC Article
High-frequency ventilation in preterm infants and neonates.
Ackermann BW, Klotz D, Hentschel R, Thome UH, van Kaam AH
Pediatr Res 2023 Jun;93(7):1810-1818. Epub 2022 Feb 8 doi: 10.1038/s41390-021-01639-8. PMID: 35136198Free PMC Article
Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905

Prognosis

Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144
Extracorporeal membrane oxygenation.
Ayad O, Dietrich A, Mihalov L
Emerg Med Clin North Am 2008 Nov;26(4):953-9, ix. doi: 10.1016/j.emc.2008.07.010. PMID: 19059094
Extracorporeal life support.
Skinner SC, Hirschl RB, Bartlett RH
Semin Pediatr Surg 2006 Nov;15(4):242-50. doi: 10.1053/j.sempedsurg.2006.07.003. PMID: 17055954

Clinical prediction guides

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Vitamin K and ECMO for neonatal hypoxic respiratory failure.
Lock NE, Sawyer AA, Wise L, Bhatia J, Stansfield BK
Perfusion 2022 Jul;37(5):484-492. Epub 2021 Mar 24 doi: 10.1177/02676591211003870. PMID: 33761796
Heliox for croup in children.
Moraa I, Sturman N, McGuire TM, van Driel ML
Cochrane Database Syst Rev 2021 Aug 16;8(8):CD006822. doi: 10.1002/14651858.CD006822.pub6. PMID: 34397099Free PMC Article
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905
Prenatal diagnosis and management of congenital diaphragmatic hernia.
Basurto D, Russo FM, Van der Veeken L, Van der Merwe J, Hooper S, Benachi A, De Bie F, Gomez O, Deprest J
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:93-106. Epub 2019 Jan 5 doi: 10.1016/j.bpobgyn.2018.12.010. PMID: 30772144

Recent systematic reviews

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants.
Lemyre B, Deguise MO, Benson P, Kirpalani H, Ekhaguere OA, Davis PG
Cochrane Database Syst Rev 2023 Jul 19;7(7):CD005384. doi: 10.1002/14651858.CD005384.pub3. PMID: 37466143Free PMC Article
Heliox for croup in children.
Moraa I, Sturman N, McGuire TM, van Driel ML
Cochrane Database Syst Rev 2021 Aug 16;8(8):CD006822. doi: 10.1002/14651858.CD006822.pub6. PMID: 34397099Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia.
Bauchat JR, Weiniger CF, Sultan P, Habib AS, Ando K, Kowalczyk JJ, Kato R, George RB, Palmer CM, Carvalho B
Anesth Analg 2019 Aug;129(2):458-474. doi: 10.1213/ANE.0000000000004195. PMID: 31082964
Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies.
Grobman WA, Caughey AB
Am J Obstet Gynecol 2019 Oct;221(4):304-310. Epub 2019 Feb 25 doi: 10.1016/j.ajog.2019.02.046. PMID: 30817905

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...