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Common terminology criteria for adverse events grade 3

MedGen UID:
276803
Concept ID:
C1519275
Finding
Synonyms: CTCAE grade 3; Grade 3 Severe Adverse Event; Severe Adverse Event; Standard Toxicity Grade 3
SNOMED CT: Common terminology criteria for adverse events grade 3 (446431000124107); CTCAE grade 3 (446431000124107)

Definition

Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self care activites of daily living. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCommon terminology criteria for adverse events grade 3

Professional guidelines

PubMed

Rahbar K, Essler M, Pabst KM, Eiber M, Fougère C, Prasad V, Rassek P, Hasa E, Dittmann H, Bundschuh RA, Fendler WP, Kurtinecz M, Schmall A, Verholen F, Sartor O
J Nucl Med 2023 Apr;64(4):574-578. Epub 2022 Oct 27 doi: 10.2967/jnumed.122.264456. PMID: 36302656Free PMC Article
Wigle TJ, Povitz BL, Medwid S, Teft WA, Legan RM, Lenehan J, Nevison S, Panuganty V, Keller D, Mailloux J, Siebring V, Sarma S, Choi YH, Welch S, Winquist E, Schwarz UI, Kim RB
Clin Transl Sci 2021 Jul;14(4):1338-1348. Epub 2021 Feb 23 doi: 10.1111/cts.12981. PMID: 33620159Free PMC Article
Grass F, Vuagniaux A, Teixeira-Farinha H, Lehmann K, Demartines N, Hübner M
Br J Surg 2017 May;104(6):669-678. doi: 10.1002/bjs.10521. PMID: 28407227

Recent clinical studies

Etiology

Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article

Diagnosis

Conte P, Ascierto PA, Patelli G, Danesi R, Vanzulli A, Sandomenico F, Tarsia P, Cattelan A, Comes A, De Laurentiis M, Falcone A, Regge D, Richeldi L, Siena S
ESMO Open 2022 Apr;7(2):100404. Epub 2022 Feb 24 doi: 10.1016/j.esmoop.2022.100404. PMID: 35219244Free PMC Article
Zacherl MJ, Gildehaus FJ, Mittlmeier L, Böning G, Gosewisch A, Wenter V, Unterrainer M, Schmidt-Hegemann N, Belka C, Kretschmer A, Casuscelli J, Stief CG, Unterrainer M, Bartenstein P, Todica A, Ilhan H
J Nucl Med 2021 May 10;62(5):669-674. Epub 2020 Oct 2 doi: 10.2967/jnumed.120.251017. PMID: 33008928
Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, Lu Q, Gao H, Jiang H, Wang H, Yuan D, Ma H, Wang H, Li Z, Zhai B
Clin Cancer Res 2020 Aug 1;26(15):3979-3989. Epub 2020 May 5 doi: 10.1158/1078-0432.CCR-19-3259. PMID: 32371538
Parker CC, James ND, Brawley CD, Clarke NW, Hoyle AP, Ali A, Ritchie AWS, Attard G, Chowdhury S, Cross W, Dearnaley DP, Gillessen S, Gilson C, Jones RJ, Langley RE, Malik ZI, Mason MD, Matheson D, Millman R, Russell JM, Thalmann GN, Amos CL, Alonzi R, Bahl A, Birtle A, Din O, Douis H, Eswar C, Gale J, Gannon MR, Jonnada S, Khaksar S, Lester JF, O'Sullivan JM, Parikh OA, Pedley ID, Pudney DM, Sheehan DJ, Srihari NN, Tran ATH, Parmar MKB, Sydes MR; Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2018 Dec 1;392(10162):2353-2366. Epub 2018 Oct 21 doi: 10.1016/S0140-6736(18)32486-3. PMID: 30355464Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Therapy

Misawa S, Denda T, Kodama S, Suzuki T, Naito Y, Kogawa T, Takada M, Suichi T, Shiosakai K, Kuwabara S; MiroCIP study group
BMC Cancer 2023 Nov 11;23(1):1098. doi: 10.1186/s12885-023-11560-4. PMID: 37951905Free PMC Article
Li D, Sun CL, Kim H, Soto-Perez-de-Celis E, Chung V, Koczywas M, Fakih M, Chao J, Cabrera Chien L, Charles K, Hughes SFDS, Katheria V, Trent M, Roberts E, Jayani R, Moreno J, Kelly C, Sedrak MS, Dale W
JAMA Oncol 2021 Nov 1;7(11):e214158. Epub 2021 Nov 18 doi: 10.1001/jamaoncol.2021.4158. PMID: 34591080Free PMC Article
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, Lu Q, Gao H, Jiang H, Wang H, Yuan D, Ma H, Wang H, Li Z, Zhai B
Clin Cancer Res 2020 Aug 1;26(15):3979-3989. Epub 2020 May 5 doi: 10.1158/1078-0432.CCR-19-3259. PMID: 32371538
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article

Prognosis

Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543Free PMC Article
Folch EE, Pritchett MA, Nead MA, Bowling MR, Murgu SD, Krimsky WS, Murillo BA, LeMense GP, Minnich DJ, Bansal S, Ellis BQ, Mahajan AK, Gildea TR, Bechara RI, Sztejman E, Flandes J, Rickman OB, Benzaquen S, Hogarth DK, Linden PA, Wahidi MM, Mattingley JS, Hood KL, Lin H, Wolvers JJ, Khandhar SJ; NAVIGATE Study Investigators
J Thorac Oncol 2019 Mar;14(3):445-458. Epub 2018 Nov 23 doi: 10.1016/j.jtho.2018.11.013. PMID: 30476574
Chun SG, Hu C, Choy H, Komaki RU, Timmerman RD, Schild SE, Bogart JA, Dobelbower MC, Bosch W, Galvin JM, Kavadi VS, Narayan S, Iyengar P, Robinson CG, Wynn RB, Raben A, Augspurger ME, MacRae RM, Paulus R, Bradley JD
J Clin Oncol 2017 Jan;35(1):56-62. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.69.1378. PMID: 28034064Free PMC Article
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Clinical prediction guides

Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Misawa S, Denda T, Kodama S, Suzuki T, Naito Y, Kogawa T, Takada M, Suichi T, Shiosakai K, Kuwabara S; MiroCIP study group
BMC Cancer 2023 Nov 11;23(1):1098. doi: 10.1186/s12885-023-11560-4. PMID: 37951905Free PMC Article
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Extermann M, Boler I, Reich RR, Lyman GH, Brown RH, DeFelice J, Levine RM, Lubiner ET, Reyes P, Schreiber FJ 3rd, Balducci L
Cancer 2012 Jul 1;118(13):3377-86. Epub 2011 Nov 9 doi: 10.1002/cncr.26646. PMID: 22072065
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M, Cecchi F, Arecco L, Fraguglia M, Pronzato P, Genova C, Del Mastro L, Lambertini M, Spagnolo F
Eur J Cancer 2023 Jul;188:64-79. Epub 2023 Apr 24 doi: 10.1016/j.ejca.2023.04.010. PMID: 37196485
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article
Stub T, Kristoffersen AE, Overvåg G, Jong MC, Musial F, Liu J
Explore (NY) 2022 Jan-Feb;18(1):114-128. Epub 2020 Nov 28 doi: 10.1016/j.explore.2020.11.008. PMID: 33303386
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Tempfer CB, Solass W, Reymond MA
Wien Med Wochenschr 2014 Dec;164(23-24):519-28. Epub 2014 Sep 24 doi: 10.1007/s10354-014-0312-y. PMID: 25249025

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