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Necrotizing Enterocolitis, AE

MedGen UID:
1656809
Concept ID:
C4724085
Finding
Synonym: Necrotizing Enterocolitis, Adverse Event

Definition

An adverse event in newborns characterized by extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis in the intestines . [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Ohlsson A, Walia R, Shah SS
Cochrane Database Syst Rev 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. PMID: 32045960Free PMC Article
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent clinical studies

Etiology

Salem A, Patel RM
Clin Perinatol 2023 Sep;50(3):669-681. Epub 2023 Jun 20 doi: 10.1016/j.clp.2023.04.014. PMID: 37536771
Kumar J, Anne RP, Meena J, Sundaram V, Dutta S, Kumar P
Eur J Pediatr 2023 Jun;182(6):2759-2773. Epub 2023 Apr 4 doi: 10.1007/s00431-023-04950-0. PMID: 37014443
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Ficara M, Pietrella E, Spada C, Della Casa Muttini E, Lucaccioni L, Iughetti L, Berardi A
J Matern Fetal Neonatal Med 2020 Mar;33(6):1036-1043. Epub 2018 Sep 10 doi: 10.1080/14767058.2018.1506760. PMID: 30058404
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Diagnosis

Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korček P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Baş M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pisoni S, Wang L, Smits A, Sanchez-Salmador R, Rasmussen MI, Olsen MH, Jensen AK, Gluud C, Jakobsen JC, Greisen G
N Engl J Med 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554. PMID: 37075142
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Therapy

Salem A, Patel RM
Clin Perinatol 2023 Sep;50(3):669-681. Epub 2023 Jun 20 doi: 10.1016/j.clp.2023.04.014. PMID: 37536771
Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Kumar J, Anne RP, Meena J, Sundaram V, Dutta S, Kumar P
Eur J Pediatr 2023 Jun;182(6):2759-2773. Epub 2023 Apr 4 doi: 10.1007/s00431-023-04950-0. PMID: 37014443
Walsh V, Brown JVE, Copperthwaite BR, Oddie SJ, McGuire W
Cochrane Database Syst Rev 2020 Dec 27;12(12):CD013542. doi: 10.1002/14651858.CD013542.pub2. PMID: 33368149Free PMC Article
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Prognosis

Jasani B, Mitra S, Shah PS
Cochrane Database Syst Rev 2022 Dec 15;12:CD010061. doi: 10.1002/14651858.CD010061.pub5. PMID: 36519620
Williams MJ, Ramson JA, Brownfoot FC
Cochrane Database Syst Rev 2022 Aug 9;8(8):CD006764. doi: 10.1002/14651858.CD006764.pub4. PMID: 35943347Free PMC Article
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article

Clinical prediction guides

Salem A, Patel RM
Clin Perinatol 2023 Sep;50(3):669-681. Epub 2023 Jun 20 doi: 10.1016/j.clp.2023.04.014. PMID: 37536771
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent systematic reviews

Mitra S, de Boode WP, Weisz DE, Shah PS
Cochrane Database Syst Rev 2023 Apr 11;4(4):CD013588. doi: 10.1002/14651858.CD013588.pub2. PMID: 37039501Free PMC Article
Korang SK, Safi S, Nava C, Gordon A, Gupta M, Greisen G, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 17;5(5):CD013837. doi: 10.1002/14651858.CD013837.pub2. PMID: 33998666Free PMC Article
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article

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