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Serious Adverse Experience

MedGen UID:
1633145
•Concept ID:
C4553214
•
Finding
Synonym: SAE

Definition

A situation referring to a severe reaction, risk or indication against use of a treatment or device. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerious Adverse Experience

Professional guidelines

PubMed

Efficacy and safety of bevacizumab for vestibular schwannoma in neurofibromatosis type 2: a systematic review and meta-analysis of treatment outcomes.
Lu VM, Ravindran K, Graffeo CS, Perry A, Van Gompel JJ, Daniels DJ, Link MJ
J Neurooncol 2019 Sep;144(2):239-248. Epub 2019 Jun 28 doi: 10.1007/s11060-019-03234-8. PMID: 31254266
Asymptomatic malrotation: Diagnosis and surgical management: An American Pediatric Surgical Association outcomes and evidence based practice committee systematic review.
Graziano K, Islam S, Dasgupta R, Lopez ME, Austin M, Chen LE, Goldin A, Downard CD, Renaud E, Abdullah F
J Pediatr Surg 2015 Oct;50(10):1783-90. Epub 2015 Jun 30 doi: 10.1016/j.jpedsurg.2015.06.019. PMID: 26205079
Use of the Beers criteria to identify potentially inappropriate drug use by community-dwelling older dental patients.
Skaar DD, O'Connor HL
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Jun;113(6):714-21. Epub 2012 Apr 3 doi: 10.1016/j.oooo.2011.12.009. PMID: 22668700

Recent clinical studies

Etiology

Resistance exercise training at different loads in frail and healthy older adults: A randomised feasibility trial.
Marshall-McKenna R, Campbell E, Ho F, Banger M, Ireland J, Rowe P, McAlpine C, McArthur K, Quinn TJ, Gray SR
Exp Gerontol 2021 Oct 1;153:111496. Epub 2021 Jul 21 doi: 10.1016/j.exger.2021.111496. PMID: 34302941Free PMC Article
Use of the Beers criteria to identify potentially inappropriate drug use by community-dwelling older dental patients.
Skaar DD, O'Connor HL
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Jun;113(6):714-21. Epub 2012 Apr 3 doi: 10.1016/j.oooo.2011.12.009. PMID: 22668700
Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
Tariot PN, Jakimovich LJ, Erb R, Cox C, Lanning B, Irvine C, Podgorski CA
J Clin Psychiatry 1999 Oct;60(10):684-9. doi: 10.4088/jcp.v60n1007. PMID: 10549685
Efficacy and safety of etodolac and naproxen in patients with osteoarthritis of the knee: a double-blind, placebo-controlled study.
Dore R, Ballard I, Constantine G, McDonald P
Clin Ther 1995 Jul-Aug;17(4):656-66. doi: 10.1016/0149-2918(95)80042-5. PMID: 8565029
Worldwide experience with the CR326F-derived inactivated hepatitis A virus vaccine in pediatric and adult populations: an overview.
Nalin DR, Kuter BJ, Brown L, Patterson C, Calandra GB, Werzberger A, Shouval D, Ellerbeck E, Block SL, Bishop R
J Hepatol 1993;18 Suppl 2:S51-5. doi: 10.1016/s0168-8278(05)80379-4. PMID: 8182275

Diagnosis

Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
Tariot PN, Jakimovich LJ, Erb R, Cox C, Lanning B, Irvine C, Podgorski CA
J Clin Psychiatry 1999 Oct;60(10):684-9. doi: 10.4088/jcp.v60n1007. PMID: 10549685

Therapy

Resistance exercise training at different loads in frail and healthy older adults: A randomised feasibility trial.
Marshall-McKenna R, Campbell E, Ho F, Banger M, Ireland J, Rowe P, McAlpine C, McArthur K, Quinn TJ, Gray SR
Exp Gerontol 2021 Oct 1;153:111496. Epub 2021 Jul 21 doi: 10.1016/j.exger.2021.111496. PMID: 34302941Free PMC Article
Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease.
Kosoglou T, Hubbell J, Xuan F, Cutler DL, Meehan AG, Kantesaria B, Wittmer BA
Int J Chron Obstruct Pulmon Dis 2013;8:107-16. Epub 2013 Mar 4 doi: 10.2147/COPD.S36592. PMID: 23525511Free PMC Article
Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
Tariot PN, Jakimovich LJ, Erb R, Cox C, Lanning B, Irvine C, Podgorski CA
J Clin Psychiatry 1999 Oct;60(10):684-9. doi: 10.4088/jcp.v60n1007. PMID: 10549685
Stevens-Johnson syndrome associated with carvedilol therapy.
Kowalski BJ, Cody RJ
Am J Cardiol 1997 Sep 1;80(5):669-70. doi: 10.1016/s0002-9149(97)00449-9. PMID: 9295009
Worldwide experience with the CR326F-derived inactivated hepatitis A virus vaccine in pediatric and adult populations: an overview.
Nalin DR, Kuter BJ, Brown L, Patterson C, Calandra GB, Werzberger A, Shouval D, Ellerbeck E, Block SL, Bishop R
J Hepatol 1993;18 Suppl 2:S51-5. doi: 10.1016/s0168-8278(05)80379-4. PMID: 8182275

Prognosis

Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy.
Graf WD, Oleinik OE, Glauser TA, Maertens P, Eder DN, Pippenger CE
Neuropediatrics 1998 Aug;29(4):195-201. doi: 10.1055/s-2007-973560. PMID: 9762695

Clinical prediction guides

Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
Tariot PN, Jakimovich LJ, Erb R, Cox C, Lanning B, Irvine C, Podgorski CA
J Clin Psychiatry 1999 Oct;60(10):684-9. doi: 10.4088/jcp.v60n1007. PMID: 10549685

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