U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adverse Event Following Immunization

MedGen UID:
811073
•Concept ID:
C2721654
•
Pathologic Function

Definition

Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the previous administration of vaccine(s) that may or may not be considered related to the vaccine administration. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with other product(s) or procedure(s). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdverse Event Following Immunization

Professional guidelines

PubMed

Vaccination attitudes, beliefs and behaviours among primary health care workers in northern Croatia.
Tomljenovic M, Petrovic G, Antoljak N, Hansen L
Vaccine 2021 Jan 22;39(4):738-745. Epub 2020 Dec 30 doi: 10.1016/j.vaccine.2020.11.049. PMID: 33386176
Primary immunodeficiency disease: a retrospective study of 112 Chinese children in a single tertiary care center.
Wu J, Zhong W, Yin Y, Zhang H
BMC Pediatr 2019 Nov 4;19(1):410. doi: 10.1186/s12887-019-1729-7. PMID: 31684895Free PMC Article

Recent clinical studies

Etiology

Anaphylaxis: Revision of the Brighton collaboration case definition.
Gold MS, Amarasinghe A, Greenhawt M, Kelso JM, Kochhar S, Yu-Hor Thong B, Top KA, Turner PJ, Worm M, Law B
Vaccine 2023 Apr 6;41(15):2605-2614. Epub 2022 Nov 24 doi: 10.1016/j.vaccine.2022.11.027. PMID: 36435707
Booster immunization of meningococcal meningitis vaccine among children in Hangzhou, China, 2014-2019.
Che X, Liu Y, Wang J, Xu Y, Zhang X, Gu W, Jiang W, Du J, Zhang X
PLoS One 2021;16(5):e0251567. Epub 2021 May 25 doi: 10.1371/journal.pone.0251567. PMID: 34032806Free PMC Article
Immunization stress-related response - Redefining immunization anxiety-related reaction as an adverse event following immunization.
Gold MS, MacDonald NE, McMurtry CM, Balakrishnan MR, Heininger U, Menning L, Benes O, Pless R, Zuber PLF
Vaccine 2020 Mar 23;38(14):3015-3020. Epub 2020 Mar 2 doi: 10.1016/j.vaccine.2020.02.046. PMID: 32131975
Recipient vaccine-associated paralytic poliomyelitis in China, 2010-2015.
Wu W, Wang H, Li K, Pekka Nuorti J, Liu D, Xu D, Ye J, Zheng J, Fan C, Wen N, An Z
Vaccine 2018 Feb 21;36(9):1209-1213. doi: 10.1016/j.vaccine.2018.01.019. PMID: 29395524
A systematic review of adverse events following immunization during pregnancy and the newborn period.
Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB
Vaccine 2015 Nov 25;33(47):6453-65. Epub 2015 Sep 26 doi: 10.1016/j.vaccine.2015.08.043. PMID: 26413879Free PMC Article

Diagnosis

Adverse event following immunization or vaccination in children in Minas Gerais: 2015 to 2020.
Camargos SM, Oliveira MLS, Luvisaro BMO, Silva TPRD, Souza JFA, Vimieiro AM, Silva TMRD, Matozinhos FP
Rev Bras Epidemiol 2023;26:e230056. Epub 2023 Dec 11 doi: 10.1590/1980-549720230056. PMID: 38088715Free PMC Article
Real-world vaccination status of children with hematologic tumors before and after chemotherapy.
Ji C, Shen H, Li M, Liu Y, Zhang X, Guo J, Xu Y
Expert Rev Vaccines 2023 Jan-Dec;22(1):440-446. doi: 10.1080/14760584.2023.2211668. PMID: 37148154
Anaphylaxis: Revision of the Brighton collaboration case definition.
Gold MS, Amarasinghe A, Greenhawt M, Kelso JM, Kochhar S, Yu-Hor Thong B, Top KA, Turner PJ, Worm M, Law B
Vaccine 2023 Apr 6;41(15):2605-2614. Epub 2022 Nov 24 doi: 10.1016/j.vaccine.2022.11.027. PMID: 36435707
Clinical Features of Post-Vaccination Guillain-Barré Syndrome (GBS) in Korea.
Park YS, Lee KJ, Kim SW, Kim KM, Suh BC
J Korean Med Sci 2017 Jul;32(7):1154-1159. doi: 10.3346/jkms.2017.32.7.1154. PMID: 28581273Free PMC Article
A systematic review of adverse events following immunization during pregnancy and the newborn period.
Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB
Vaccine 2015 Nov 25;33(47):6453-65. Epub 2015 Sep 26 doi: 10.1016/j.vaccine.2015.08.043. PMID: 26413879Free PMC Article

Therapy

Real-world vaccination status of children with hematologic tumors before and after chemotherapy.
Ji C, Shen H, Li M, Liu Y, Zhang X, Guo J, Xu Y
Expert Rev Vaccines 2023 Jan-Dec;22(1):440-446. doi: 10.1080/14760584.2023.2211668. PMID: 37148154
Anaphylaxis: Revision of the Brighton collaboration case definition.
Gold MS, Amarasinghe A, Greenhawt M, Kelso JM, Kochhar S, Yu-Hor Thong B, Top KA, Turner PJ, Worm M, Law B
Vaccine 2023 Apr 6;41(15):2605-2614. Epub 2022 Nov 24 doi: 10.1016/j.vaccine.2022.11.027. PMID: 36435707
Clinical Features of Post-Vaccination Guillain-Barré Syndrome (GBS) in Korea.
Park YS, Lee KJ, Kim SW, Kim KM, Suh BC
J Korean Med Sci 2017 Jul;32(7):1154-1159. doi: 10.3346/jkms.2017.32.7.1154. PMID: 28581273Free PMC Article
A global survey of adverse event following immunization surveillance systems for pregnant women and their infants.
Cassidy C, MacDonald NE, Steenbeek A, Ortiz JR, Zuber PL, Top KA
Hum Vaccin Immunother 2016 Aug 2;12(8):2010-2016. Epub 2016 May 9 doi: 10.1080/21645515.2016.1175697. PMID: 27159639Free PMC Article
A systematic review of adverse events following immunization during pregnancy and the newborn period.
Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB
Vaccine 2015 Nov 25;33(47):6453-65. Epub 2015 Sep 26 doi: 10.1016/j.vaccine.2015.08.043. PMID: 26413879Free PMC Article

Prognosis

Background rates of adverse events of special interest for COVID-19 vaccines: A multinational Global Vaccine Data Network (GVDN) analysis.
Phillips A, Jiang Y, Walsh D, Andrews N, Artama M, Clothier H, Cullen L, Deng L, Escolano S, Gentile A, Gidding G, Giglio N, Junker T, Huang W, Janjua N, Kwong J, Li J, Nasreen S, Naus M, Naveed Z, Pillsbury A, Stowe J, Vo T, Buttery J, Petousis-Harris H, Black S, Hviid A
Vaccine 2023 Oct 6;41(42):6227-6238. Epub 2023 Sep 5 doi: 10.1016/j.vaccine.2023.08.079. PMID: 37673715
Incidence of Guillain-Barré syndrome following SARS-CoV-2 immunization: Analysis of a nationwide registry of recipients of 81 million doses of seven vaccines.
García-Grimshaw M, Galnares-Olalde JA, Bello-Chavolla OY, Michel-Chávez A, Cadena-Fernández A, Briseño-Godínez ME, Antonio-Villa NE, Núñez I, Gutiérrez-Romero A, Hernández-Vanegas L, Del Mar Saniger-Alba M, Carrillo-Mezo R, Ceballos-Liceaga SE, Carbajal-Sandoval G, Flores-Silva FD, Díaz-Ortega JL, Cortes-Alcalá R, Pérez-Padilla JR, López-Gatell H, Chiquete E, Reyes-Terán G, Arauz A, Valdés-Ferrer SI
Eur J Neurol 2022 Nov;29(11):3368-3379. Epub 2022 Aug 2 doi: 10.1111/ene.15504. PMID: 35841212Free PMC Article
Vaccination attitudes, beliefs and behaviours among primary health care workers in northern Croatia.
Tomljenovic M, Petrovic G, Antoljak N, Hansen L
Vaccine 2021 Jan 22;39(4):738-745. Epub 2020 Dec 30 doi: 10.1016/j.vaccine.2020.11.049. PMID: 33386176
Post Marketing Surveillance Study of 2nd Dose Quadrivalent Human Papilloma Virus Vaccine in Elementary School Children in Jakarta, Indonesia: Safety Result and Implementation of School-Based HPV Immunization Program.
Satari HI, Sundoro J, Andrijono A, Hadinegoro SR, Syafriyal S, Tandy G, Karolina S
Asian Pac J Cancer Prev 2019 Mar 26;20(3):869-875. doi: 10.31557/APJCP.2019.20.3.869. PMID: 30912406Free PMC Article
An approach to death as an adverse event following immunization.
Gold MS, Balakrishnan MR, Amarasinghe A, MacDonald NE
Vaccine 2016 Jan 4;34(2):212-217. Epub 2015 Nov 19 doi: 10.1016/j.vaccine.2015.11.018. PMID: 26608326

Clinical prediction guides

Anaphylaxis: Revision of the Brighton collaboration case definition.
Gold MS, Amarasinghe A, Greenhawt M, Kelso JM, Kochhar S, Yu-Hor Thong B, Top KA, Turner PJ, Worm M, Law B
Vaccine 2023 Apr 6;41(15):2605-2614. Epub 2022 Nov 24 doi: 10.1016/j.vaccine.2022.11.027. PMID: 36435707
Stroke Among SARS-CoV-2 Vaccine Recipients in Mexico: A Nationwide Descriptive Study.
López-Mena D, García-Grimshaw M, Saldivar-Dávila S, Hernandez-Vanegas LE, Saniger-Alba MDM, Gutiérrez-Romero A, Carrillo-Mezo R, Valdez-Ruvalcaba HE, Cano-Nigenda V, Flores-Silva FD, Cantú-Brito C, Santibañez-Copado AM, Diaz-Ortega JL, Ceballos-Liceaga SE, Murillo-Bonilla LM, Sepulveda-Núñez AI, García-Talavera V, Gonzalez-Guerra E, Cortes-Alcala R, Lopez-Gatell H, Carbajal-Sandoval G, Reyes-Terán G, Valdés-Ferrer SI, Arauz A
Neurology 2022 May 10;98(19):e1933-e1941. Epub 2022 Mar 11 doi: 10.1212/WNL.0000000000200388. PMID: 35277439Free PMC Article
Adverse reactions to the BNT162b2 and mRNA-1273 mRNA COVID-19 vaccines in Japan.
Kitagawa H, Kaiki Y, Sugiyama A, Nagashima S, Kurisu A, Nomura T, Omori K, Akita T, Shigemoto N, Tanaka J, Ohge H
J Infect Chemother 2022 Apr;28(4):576-581. Epub 2022 Jan 11 doi: 10.1016/j.jiac.2021.12.034. PMID: 35058126Free PMC Article
A Randomized, Single Centered, Parallel and Open Labelled Interventional Study on Effectiveness of Clinical Pharmacists on Adverse Event Following Immunization (AEFI) in Pediatric Population.
Arvind RK, Beerwala FA, Wali SC, Parihar AS, Ganachari MS, Bhandari R
Curr Drug Saf 2022;17(4):357-365. doi: 10.2174/1574886317666220103092844. PMID: 35049436
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442

Recent systematic reviews

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis.
Kouhpayeh H, Ansari H
Int Immunopharmacol 2022 Aug;109:108906. Epub 2022 May 30 doi: 10.1016/j.intimp.2022.108906. PMID: 35671640Free PMC Article
Risk of Recurrence of Adverse Events Following Immunization: A Systematic Review.
Zafack JG, De Serres G, Kiely M, Gariépy MC, Rouleau I, Top KA; Canadian Immunization Research Network
Pediatrics 2017 Sep;140(3) doi: 10.1542/peds.2016-3707. PMID: 28847985
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442
A systematic review of adverse events following immunization during pregnancy and the newborn period.
Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB
Vaccine 2015 Nov 25;33(47):6453-65. Epub 2015 Sep 26 doi: 10.1016/j.vaccine.2015.08.043. PMID: 26413879Free PMC Article
Adverse event following immunization surveillance systems for pregnant women and their infants: a systematic review.
Cassidy C, MacDonald NE, Steenbeek A, Top KA
Pharmacoepidemiol Drug Saf 2015 Apr;24(4):361-7. Epub 2015 Feb 12 doi: 10.1002/pds.3754. PMID: 25683692

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...