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Immune-Mediated Adverse Reaction

MedGen UID:
1388583
•Concept ID:
C4087225
•
Pathologic Function
Synonym: Immune-Related Adverse Event

Definition

An adverse event resulting from an immune system reaction to a drug or device. It can affect any organ or system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune-Mediated Adverse Reaction

Professional guidelines

PubMed

Treatment of heparin-induced thrombocytopenia.
Dager WE, White RH
Ann Pharmacother 2002 Mar;36(3):489-503. doi: 10.1345/aph.1A204. PMID: 11895064

Recent clinical studies

Etiology

Survey of Practice Pattern in Patients With Heparin-Induced Thrombocytopenia Requiring Cardiopulmonary Bypass.
Wanat-Hawthorne A, Tanaka K, Angona R, Feng C, Eaton M
Anesth Analg 2021 Nov 1;133(5):1180-1186. doi: 10.1213/ANE.0000000000005721. PMID: 34415867
Incidence and outcomes of heparin-induced thrombocytopenia in solid malignancy: an analysis of the National Inpatient Sample Database.
Kumar R, Bhandari S, Singh SRK, Malapati S, Cisak KI
Br J Haematol 2020 May;189(3):543-550. Epub 2020 Jan 28 doi: 10.1111/bjh.16400. PMID: 31990984
Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know?
Karnes JH
Pharmacogenomics 2018 Dec;19(18):1413-1422. Epub 2018 Nov 6 doi: 10.2217/pgs-2018-0147. PMID: 30398086Free PMC Article
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Cramer P, Bresalier RS
Curr Gastroenterol Rep 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. PMID: 28124291
Stress and food allergy: mechanistic considerations.
Schreier HM, Wright RJ
Ann Allergy Asthma Immunol 2014 Apr;112(4):296-301. Epub 2013 Aug 28 doi: 10.1016/j.anai.2013.08.002. PMID: 24428964Free PMC Article

Diagnosis

Survey of Practice Pattern in Patients With Heparin-Induced Thrombocytopenia Requiring Cardiopulmonary Bypass.
Wanat-Hawthorne A, Tanaka K, Angona R, Feng C, Eaton M
Anesth Analg 2021 Nov 1;133(5):1180-1186. doi: 10.1213/ANE.0000000000005721. PMID: 34415867
Fulminant myocarditis induced by immune checkpoint inhibitor nivolumab: a case report and review of the literature.
Wang F, Liu Y, Xu W, Zhang C, Lv J, Ma S
J Med Case Rep 2021 Jul 6;15(1):336. doi: 10.1186/s13256-021-02934-y. PMID: 34225811Free PMC Article
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Cramer P, Bresalier RS
Curr Gastroenterol Rep 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. PMID: 28124291
Non-IgE mediated food allergy.
Jyonouchi H
Inflamm Allergy Drug Targets 2008 Sep;7(3):173-80. doi: 10.2174/187152808785748119. PMID: 18782024
Treatment of heparin-induced thrombocytopenia.
Dager WE, White RH
Ann Pharmacother 2002 Mar;36(3):489-503. doi: 10.1345/aph.1A204. PMID: 11895064

Therapy

Survey of Practice Pattern in Patients With Heparin-Induced Thrombocytopenia Requiring Cardiopulmonary Bypass.
Wanat-Hawthorne A, Tanaka K, Angona R, Feng C, Eaton M
Anesth Analg 2021 Nov 1;133(5):1180-1186. doi: 10.1213/ANE.0000000000005721. PMID: 34415867
Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know?
Karnes JH
Pharmacogenomics 2018 Dec;19(18):1413-1422. Epub 2018 Nov 6 doi: 10.2217/pgs-2018-0147. PMID: 30398086Free PMC Article
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Cramer P, Bresalier RS
Curr Gastroenterol Rep 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. PMID: 28124291
Non-IgE mediated food allergy.
Jyonouchi H
Inflamm Allergy Drug Targets 2008 Sep;7(3):173-80. doi: 10.2174/187152808785748119. PMID: 18782024
Treatment of heparin-induced thrombocytopenia.
Dager WE, White RH
Ann Pharmacother 2002 Mar;36(3):489-503. doi: 10.1345/aph.1A204. PMID: 11895064

Prognosis

Incidence and outcomes of heparin-induced thrombocytopenia in solid malignancy: an analysis of the National Inpatient Sample Database.
Kumar R, Bhandari S, Singh SRK, Malapati S, Cisak KI
Br J Haematol 2020 May;189(3):543-550. Epub 2020 Jan 28 doi: 10.1111/bjh.16400. PMID: 31990984
Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know?
Karnes JH
Pharmacogenomics 2018 Dec;19(18):1413-1422. Epub 2018 Nov 6 doi: 10.2217/pgs-2018-0147. PMID: 30398086Free PMC Article
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Cramer P, Bresalier RS
Curr Gastroenterol Rep 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. PMID: 28124291
Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes.
Ravkov EV, Pavlov IY, Martins TB, Gleich GJ, Wagner LA, Hill HR, Delgado JC
Hum Immunol 2013 Dec;74(12):1542-9. Epub 2013 Aug 28 doi: 10.1016/j.humimm.2013.08.276. PMID: 23993987Free PMC Article
Argatroban therapy for heparin-induced thrombocytopenia in acutely ill patients.
Gray A, Wallis DE, Hursting MJ, Katz E, Lewis BE
Clin Appl Thromb Hemost 2007 Oct;13(4):353-61. doi: 10.1177/1076029607303617. PMID: 17911186

Clinical prediction guides

Mucosal Immunoregulatory Properties of Tsukamurella inchonensis to Reverse Experimental Food Allergy.
Smaldini PL, Trejo FM, Rizzo GP, Comerci DJ, Kampinga J, Docena GH
Front Immunol 2021;12:641597. Epub 2021 Apr 30 doi: 10.3389/fimmu.2021.641597. PMID: 33995359Free PMC Article
Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know?
Karnes JH
Pharmacogenomics 2018 Dec;19(18):1413-1422. Epub 2018 Nov 6 doi: 10.2217/pgs-2018-0147. PMID: 30398086Free PMC Article
Gastrointestinal and Hepatic Complications of Immune Checkpoint Inhibitors.
Cramer P, Bresalier RS
Curr Gastroenterol Rep 2017 Jan;19(1):3. doi: 10.1007/s11894-017-0540-6. PMID: 28124291
Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes.
Ravkov EV, Pavlov IY, Martins TB, Gleich GJ, Wagner LA, Hill HR, Delgado JC
Hum Immunol 2013 Dec;74(12):1542-9. Epub 2013 Aug 28 doi: 10.1016/j.humimm.2013.08.276. PMID: 23993987Free PMC Article
Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study.
Saugel B, Phillip V, Moessmer G, Schmid RM, Huber W
Crit Care 2010;14(3):R90. Epub 2010 May 20 doi: 10.1186/cc9024. PMID: 20487559Free PMC Article

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