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Immune System Disorders, CTCAE

MedGen UID:
1631676
•Concept ID:
C4553107
•
Finding

Professional guidelines

PubMed

Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
Nivolumab plus Brentuximab vedotin +/- bendamustine combination therapy: a safe and effective treatment in pediatric recurrent and refractory classical Hodgkin lymphoma.
Greve P, Beishuizen A, Hagleitner M, Loeffen J, Veening M, Boes M, Peperzak V, Diez C, Meyer-Wentrup F
Front Immunol 2023;14:1229558. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1229558. PMID: 37583696Free PMC Article
Skin Reactions in Patients With Multiple Sclerosis Receiving Cladribine Treatment.
Rolfes L, Pfeuffer S, Hackert J, Pawlitzki M, Ruck T, Sondermann W, Korsen M, Wiendl H, Meuth SG, Kleinschnitz C, Pul R
Neurol Neuroimmunol Neuroinflamm 2021 May;8(3) Epub 2021 Apr 9 doi: 10.1212/NXI.0000000000000990. PMID: 33837059Free PMC Article

Recent clinical studies

Etiology

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
Treosulfan vs busulfan conditioning for allogeneic bmt in children with nonmalignant disease: a randomized phase 2 trial.
Sykora KW, Beier R, Schulz A, Cesaro S, Greil J, Gozdzik J, Sedlacek P, Bader P, Schulte J, Zecca M, Locatelli F, Gruhn B, Reinhardt D, Styczynski J, Piras S, Fagioli F, Bonanomi S, Caniglia M, Li X, Baumgart J, Kehne J, Mielcarek-Siedziuk M, Kalwak K
Bone Marrow Transplant 2024 Jan;59(1):107-116. Epub 2023 Nov 4 doi: 10.1038/s41409-023-02135-9. PMID: 37925531Free PMC Article
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article
Retrospective review of accelerated daratumumab administration.
Patel A, Clark S, Espiritu J, Dechen T, Tran Q
J Oncol Pharm Pract 2022 Jun;28(4):816-821. Epub 2021 Apr 17 doi: 10.1177/10781552211009967. PMID: 33866892

Diagnosis

Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
A cross-sectional study of patient-reported outcomes and symptom burden using PROMIS and PRO-CTCAE measures in light chain amyloidosis.
D'Souza A, Szabo A, Akinola I, Finkel M, Flynn KE
Qual Life Res 2023 Jun;32(6):1807-1817. Epub 2023 Feb 4 doi: 10.1007/s11136-023-03354-9. PMID: 36738402Free PMC Article
Hematologic abnormalities in Aicardi Goutières Syndrome.
Adang LA, Gavazzi F, D'Aiello R, Isaacs D, Bronner N, Arici ZS, Flores Z, Jan A, Scher C, Sherbini O, Behrens EM, Goldbach-Mansky R, Olson TS, Lambert MP, Sullivan KE, Teachey DT, Witmer C, Vanderver A, Shults J
Mol Genet Metab 2022 Aug;136(4):324-329. Epub 2022 Jun 16 doi: 10.1016/j.ymgme.2022.06.003. PMID: 35786528Free PMC Article
Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.
Zhi WI, Ingram E, Li SQ, Chen P, Piulson L, Bao T
Integr Cancer Ther 2018 Dec;17(4):1079-1086. Epub 2018 Jul 20 doi: 10.1177/1534735418788667. PMID: 30027756Free PMC Article
Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy.
Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Mcarthur JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R
Muscle Nerve 2017 Mar;55(3):366-372. Epub 2016 Dec 23 doi: 10.1002/mus.25264. PMID: 27447116Free PMC Article

Therapy

Daratumumab and antineoplastic therapy versus antineoplastic therapy only for adults with newly diagnosed multiple myeloma ineligible for transplant.
Langer P, John L, Monsef I, Scheid C, Piechotta V, Skoetz N
Cochrane Database Syst Rev 2024 May 2;5(5):CD013595. doi: 10.1002/14651858.CD013595.pub2. PMID: 38695605Free PMC Article
Treosulfan vs busulfan conditioning for allogeneic bmt in children with nonmalignant disease: a randomized phase 2 trial.
Sykora KW, Beier R, Schulz A, Cesaro S, Greil J, Gozdzik J, Sedlacek P, Bader P, Schulte J, Zecca M, Locatelli F, Gruhn B, Reinhardt D, Styczynski J, Piras S, Fagioli F, Bonanomi S, Caniglia M, Li X, Baumgart J, Kehne J, Mielcarek-Siedziuk M, Kalwak K
Bone Marrow Transplant 2024 Jan;59(1):107-116. Epub 2023 Nov 4 doi: 10.1038/s41409-023-02135-9. PMID: 37925531Free PMC Article
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas.
Tschernia NP, Heiling H, Deal AM, Cheng C, Babinec C, Gonzalez M, Morrison JK, Dittus C, Dotti G, Beaven AW, Serody JS, Wood WA, Savoldo B, Grover NS
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-006959. PMID: 37527906Free PMC Article
Hematologic abnormalities in Aicardi Goutières Syndrome.
Adang LA, Gavazzi F, D'Aiello R, Isaacs D, Bronner N, Arici ZS, Flores Z, Jan A, Scher C, Sherbini O, Behrens EM, Goldbach-Mansky R, Olson TS, Lambert MP, Sullivan KE, Teachey DT, Witmer C, Vanderver A, Shults J
Mol Genet Metab 2022 Aug;136(4):324-329. Epub 2022 Jun 16 doi: 10.1016/j.ymgme.2022.06.003. PMID: 35786528Free PMC Article
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article

Prognosis

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
The effective radiation dose to immune cells predicts lymphopenia and inferior cancer control in locally advanced NSCLC.
Friedes C, Iocolano M, Lee SH, Duan L, Li B, Doucette A, Cohen RB, Aggarwal C, Sun LL, Levin WP, Cengel KA, Kao G, Teo BK, Langer CJ, Xiao Y, Bradley J, Feigenberg SJ, Yegya-Raman N
Radiother Oncol 2024 Jan;190:110030. Epub 2023 Nov 24 doi: 10.1016/j.radonc.2023.110030. PMID: 38008414
Immunological consequences of cladribine treatment in multiple sclerosis: A real-world study.
Rolfes L, Pfeuffer S, Huntemann N, Schmidt M, Su C, Skuljec J, Aslan D, Hackert J, Kleinschnitz K, Hagenacker T, Pawlitzki M, Ruck T, Kleinschnitz C, Meuth SG, Pul R
Mult Scler Relat Disord 2022 Aug;64:103931. Epub 2022 May 29 doi: 10.1016/j.msard.2022.103931. PMID: 35690010
Effectiveness and tolerability of radiotherapy for patients with indolent non-Hodgkin's lymphoma: a monocenter analysis.
Hadi I, Schummer A, Dreyling M, Eze C, Bodensohn R, Roengvoraphoj O, Belka C, Li M
Sci Rep 2021 Nov 19;11(1):22586. doi: 10.1038/s41598-021-01851-w. PMID: 34799601Free PMC Article
Lymphopenia during radiotherapy in patients with oropharyngeal cancer.
Ng SP, Bahig H, Jethanandani A, Pollard C, Berends J, Sturgis EM, Johnson FM, Elgohari B, Elhalawani H, Rosenthal DI, Skinner HD, Gunn GB, Phan J, Frank SJ, Mohamed ASR, Fuller CD, Garden AS
Radiother Oncol 2020 Apr;145:95-100. Epub 2020 Jan 10 doi: 10.1016/j.radonc.2019.12.023. PMID: 31931292Free PMC Article

Clinical prediction guides

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas.
Tschernia NP, Heiling H, Deal AM, Cheng C, Babinec C, Gonzalez M, Morrison JK, Dittus C, Dotti G, Beaven AW, Serody JS, Wood WA, Savoldo B, Grover NS
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-006959. PMID: 37527906Free PMC Article
A Pilot Trial of Patient-Reported Outcomes for Acute Graft-Versus-Host-Disease.
Patel SS, Hong S, Rybicki L, Farlow S, Dabney J, Kalaycio M, Sobecks R, Majhail NS, Hamilton BK
Transplant Cell Ther 2023 Jul;29(7):465.e1-465.e7. Epub 2023 Mar 31 doi: 10.1016/j.jtct.2023.03.030. PMID: 37003415
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article
Treatment of a first patient with FLASH-radiotherapy.
Bourhis J, Sozzi WJ, Jorge PG, Gaide O, Bailat C, Duclos F, Patin D, Ozsahin M, Bochud F, Germond JF, Moeckli R, Vozenin MC
Radiother Oncol 2019 Oct;139:18-22. Epub 2019 Jul 11 doi: 10.1016/j.radonc.2019.06.019. PMID: 31303340

Recent systematic reviews

Daratumumab and antineoplastic therapy versus antineoplastic therapy only for adults with newly diagnosed multiple myeloma ineligible for transplant.
Langer P, John L, Monsef I, Scheid C, Piechotta V, Skoetz N
Cochrane Database Syst Rev 2024 May 2;5(5):CD013595. doi: 10.1002/14651858.CD013595.pub2. PMID: 38695605Free PMC Article
Upfront autologous hematopoietic stem cell transplantation consolidation for patients with aggressive B-cell lymphomas in first remission in the rituximab era: A systematic review and meta-analysis.
Epperla N, Hamadani M, Reljic T, Kharfan-Dabaja MA, Savani BN, Kumar A
Cancer 2019 Dec 15;125(24):4417-4425. Epub 2019 Aug 23 doi: 10.1002/cncr.32464. PMID: 31441943
Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy.
Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Mcarthur JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R
Muscle Nerve 2017 Mar;55(3):366-372. Epub 2016 Dec 23 doi: 10.1002/mus.25264. PMID: 27447116Free PMC Article

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