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Grade 4 Neonatal Bradyarrhythmia, AE

MedGen UID:
1665449
•Concept ID:
C4743869
•
Finding
Synonym: Grade 4 Neonatal Bradyarrhythmia, Adverse Event

Definition

A bradyarrhythmia adverse event in a newborn characterized by life-threatening consequences (e.g. shock); requiring urgent major care changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Neonatal Bradyarrhythmia, AE

Professional guidelines

PubMed

Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
Pessano S, Romantsik O, Olsson E, Hedayati E, Bruschettini M
Cochrane Database Syst Rev 2023 Sep 28;9(9):CD015594. doi: 10.1002/14651858.CD015594.pub2. PMID: 37767875Free PMC Article
Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants.
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article

Recent clinical studies

Etiology

Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3. PMID: 38096386Free PMC Article
Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation.
Lemyre B, Deguise MO, Benson P, Kirpalani H, De Paoli AG, Davis PG
Cochrane Database Syst Rev 2023 Jul 27;7(7):CD003212. doi: 10.1002/14651858.CD003212.pub4. PMID: 37497794Free PMC Article
Continuous positive airway pressure (CPAP) for apnoea of prematurity.
Ho JJ, Zakarija-Grkovic I, Lok JW, Lim E, Subramaniam P, Leong JJ
Cochrane Database Syst Rev 2023 Jul 18;7(7):CD013660. doi: 10.1002/14651858.CD013660.pub2. PMID: 37481707Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article

Diagnosis

Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3. PMID: 38096386Free PMC Article
Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Oct 23;10(10):CD015592. doi: 10.1002/14651858.CD015592.pub2. PMID: 37870133Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Safety and Efficacy of the Combination of Propofol and Ketamine for Procedural Sedation/Anesthesia in the Pediatric Population: A Systematic Review and Meta-analysis.
Hayes JA, Aljuhani T, De Oliveira K, Johnston BC
Anesth Analg 2021 Apr 1;132(4):979-992. doi: 10.1213/ANE.0000000000004967. PMID: 32665470
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome.
Morihana E, Yamamura K, Sugitani Y, Kado H, Takahata Y, Nakano T, Nakashima Y, Fusazaki N, Ohga S
Pediatr Cardiol 2018 Apr;39(4):749-756. Epub 2018 Jan 19 doi: 10.1007/s00246-018-1815-x. PMID: 29350247

Therapy

Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3. PMID: 38096386Free PMC Article
Continuous positive airway pressure (CPAP) for apnoea of prematurity.
Ho JJ, Zakarija-Grkovic I, Lok JW, Lim E, Subramaniam P, Leong JJ
Cochrane Database Syst Rev 2023 Jul 18;7(7):CD013660. doi: 10.1002/14651858.CD013660.pub2. PMID: 37481707Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article
Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6).
Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, Torevell H, Warner A, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGuire N
Br J Anaesth 2018 Jul;121(1):159-171. Epub 2018 May 21 doi: 10.1016/j.bja.2018.04.014. PMID: 29935567

Prognosis

Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6).
Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, Torevell H, Warner A, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGuire N
Br J Anaesth 2018 Jul;121(1):159-171. Epub 2018 May 21 doi: 10.1016/j.bja.2018.04.014. PMID: 29935567
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome.
Morihana E, Yamamura K, Sugitani Y, Kado H, Takahata Y, Nakano T, Nakashima Y, Fusazaki N, Ohga S
Pediatr Cardiol 2018 Apr;39(4):749-756. Epub 2018 Jan 19 doi: 10.1007/s00246-018-1815-x. PMID: 29350247
Methanol toxicity in a newborn.
Belson M, Morgan BW
J Toxicol Clin Toxicol 2004;42(5):673-7. doi: 10.1081/clt-200026980. PMID: 15462163
A multicenter randomized masked comparison trial of synthetic surfactant versus calf lung surfactant extract in the prevention of neonatal respiratory distress syndrome.
Hudak ML, Martin DJ, Egan EA, Matteson EJ, Cummings NJ, Jung AL, Kimberlin LV, Auten RL, Rosenberg AA, Asselin JM, Belcastro MR, Donohue PK, Hamm CR Jr, Jansen RD, Brody AS, Riddlesberger MM, Montgomery P
Pediatrics 1997 Jul;100(1):39-50. doi: 10.1542/peds.100.1.39. PMID: 9200358

Clinical prediction guides

Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
Pessano S, Romantsik O, Olsson E, Hedayati E, Bruschettini M
Cochrane Database Syst Rev 2023 Sep 28;9(9):CD015594. doi: 10.1002/14651858.CD015594.pub2. PMID: 37767875Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome.
Morihana E, Yamamura K, Sugitani Y, Kado H, Takahata Y, Nakano T, Nakashima Y, Fusazaki N, Ohga S
Pediatr Cardiol 2018 Apr;39(4):749-756. Epub 2018 Jan 19 doi: 10.1007/s00246-018-1815-x. PMID: 29350247
Very low birth weight infants have only few adverse events after timely immunization.
Furck AK, Richter JW, Kattner E
J Perinatol 2010 Feb;30(2):118-21. Epub 2009 Aug 27 doi: 10.1038/jp.2009.112. PMID: 19710678

Recent systematic reviews

Positioning for lumbar puncture in newborn infants.
Pessano S, Bruschettini M, Prescott MG, Romantsik O
Cochrane Database Syst Rev 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3. PMID: 38096386Free PMC Article
Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation.
Lemyre B, Deguise MO, Benson P, Kirpalani H, De Paoli AG, Davis PG
Cochrane Database Syst Rev 2023 Jul 27;7(7):CD003212. doi: 10.1002/14651858.CD003212.pub4. PMID: 37497794Free PMC Article
Continuous positive airway pressure (CPAP) for apnoea of prematurity.
Ho JJ, Zakarija-Grkovic I, Lok JW, Lim E, Subramaniam P, Leong JJ
Cochrane Database Syst Rev 2023 Jul 18;7(7):CD013660. doi: 10.1002/14651858.CD013660.pub2. PMID: 37481707Free PMC Article
Opioids for procedural pain in neonates.
Kinoshita M, Olsson E, Borys F, Bruschettini M
Cochrane Database Syst Rev 2023 Jun 23;6(6):CD015056. doi: 10.1002/14651858.CD015056.pub3. PMID: 37350685Free PMC Article
Techniques for preventing hypotension during spinal anaesthesia for caesarean section.
Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, Simmons SW, Cyna AM
Cochrane Database Syst Rev 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4. PMID: 32619039Free PMC Article

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