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Blood and Lymphatic System Disorders, CTCAE

MedGen UID:
1641996
•Concept ID:
C4553112
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlood and Lymphatic System Disorders, CTCAE

Professional guidelines

PubMed

Fix low dose venetoclax-azacitidine treatment of unfit acute myeloid leukemia patients.
Miklos E, Oliver TP, Adam K, Eva K, Balazs K, Eszter K, Anett P, Viktoria GK, Jozsef H, Peter R
Eur J Haematol 2024 Aug;113(2):183-189. Epub 2024 Apr 21 doi: 10.1111/ejh.14213. PMID: 38644361
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
Nivolumab plus Brentuximab vedotin +/- bendamustine combination therapy: a safe and effective treatment in pediatric recurrent and refractory classical Hodgkin lymphoma.
Greve P, Beishuizen A, Hagleitner M, Loeffen J, Veening M, Boes M, Peperzak V, Diez C, Meyer-Wentrup F
Front Immunol 2023;14:1229558. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1229558. PMID: 37583696Free PMC Article

Recent clinical studies

Etiology

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
Phase to phase: Navigating drug combinations with hypomethylating agents in higher-risk MDS trials for optimal outcomes.
Merz AMA, Sébert M, Sonntag J, Kubasch AS, Platzbecker U, Adès L
Cancer Treat Rev 2024 Feb;123:102673. Epub 2023 Dec 19 doi: 10.1016/j.ctrv.2023.102673. PMID: 38176221
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article

Diagnosis

Fix low dose venetoclax-azacitidine treatment of unfit acute myeloid leukemia patients.
Miklos E, Oliver TP, Adam K, Eva K, Balazs K, Eszter K, Anett P, Viktoria GK, Jozsef H, Peter R
Eur J Haematol 2024 Aug;113(2):183-189. Epub 2024 Apr 21 doi: 10.1111/ejh.14213. PMID: 38644361
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Gurieva OD, Savelyeva MI, Valiev TT, Sozaeva ZA, Kondratenko SN, Ilyin MV
Drug Metab Pers Ther 2023 Dec 1;38(4):349-357. Epub 2023 Dec 14 doi: 10.1515/dmpt-2023-0079. PMID: 38098143
Safety and efficacy of Vitamin D(3) supplementation with Imatinib in Chronic Phase- Chronic Myeloid Leukaemia: an Exploratory Randomized Controlled Trial.
Bandyopadhyay A, Palepu S, Dhamija P, Nath UK, Chetia R, Bakliwal A, Vaniyath S, Chattopadhyay D, Handu S
BMJ Open 2023 Aug 29;13(8):e066361. doi: 10.1136/bmjopen-2022-066361. PMID: 37643857Free PMC Article
Hematologic abnormalities in Aicardi Goutières Syndrome.
Adang LA, Gavazzi F, D'Aiello R, Isaacs D, Bronner N, Arici ZS, Flores Z, Jan A, Scher C, Sherbini O, Behrens EM, Goldbach-Mansky R, Olson TS, Lambert MP, Sullivan KE, Teachey DT, Witmer C, Vanderver A, Shults J
Mol Genet Metab 2022 Aug;136(4):324-329. Epub 2022 Jun 16 doi: 10.1016/j.ymgme.2022.06.003. PMID: 35786528Free PMC Article
Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.
Zhi WI, Ingram E, Li SQ, Chen P, Piulson L, Bao T
Integr Cancer Ther 2018 Dec;17(4):1079-1086. Epub 2018 Jul 20 doi: 10.1177/1534735418788667. PMID: 30027756Free PMC Article

Therapy

Phase to phase: Navigating drug combinations with hypomethylating agents in higher-risk MDS trials for optimal outcomes.
Merz AMA, Sébert M, Sonntag J, Kubasch AS, Platzbecker U, Adès L
Cancer Treat Rev 2024 Feb;123:102673. Epub 2023 Dec 19 doi: 10.1016/j.ctrv.2023.102673. PMID: 38176221
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas.
Tschernia NP, Heiling H, Deal AM, Cheng C, Babinec C, Gonzalez M, Morrison JK, Dittus C, Dotti G, Beaven AW, Serody JS, Wood WA, Savoldo B, Grover NS
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-006959. PMID: 37527906Free PMC Article
Hematologic abnormalities in Aicardi Goutières Syndrome.
Adang LA, Gavazzi F, D'Aiello R, Isaacs D, Bronner N, Arici ZS, Flores Z, Jan A, Scher C, Sherbini O, Behrens EM, Goldbach-Mansky R, Olson TS, Lambert MP, Sullivan KE, Teachey DT, Witmer C, Vanderver A, Shults J
Mol Genet Metab 2022 Aug;136(4):324-329. Epub 2022 Jun 16 doi: 10.1016/j.ymgme.2022.06.003. PMID: 35786528Free PMC Article
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article

Prognosis

Fix low dose venetoclax-azacitidine treatment of unfit acute myeloid leukemia patients.
Miklos E, Oliver TP, Adam K, Eva K, Balazs K, Eszter K, Anett P, Viktoria GK, Jozsef H, Peter R
Eur J Haematol 2024 Aug;113(2):183-189. Epub 2024 Apr 21 doi: 10.1111/ejh.14213. PMID: 38644361
Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
Phase to phase: Navigating drug combinations with hypomethylating agents in higher-risk MDS trials for optimal outcomes.
Merz AMA, Sébert M, Sonntag J, Kubasch AS, Platzbecker U, Adès L
Cancer Treat Rev 2024 Feb;123:102673. Epub 2023 Dec 19 doi: 10.1016/j.ctrv.2023.102673. PMID: 38176221
Immunological consequences of cladribine treatment in multiple sclerosis: A real-world study.
Rolfes L, Pfeuffer S, Huntemann N, Schmidt M, Su C, Skuljec J, Aslan D, Hackert J, Kleinschnitz K, Hagenacker T, Pawlitzki M, Ruck T, Kleinschnitz C, Meuth SG, Pul R
Mult Scler Relat Disord 2022 Aug;64:103931. Epub 2022 May 29 doi: 10.1016/j.msard.2022.103931. PMID: 35690010
Lymphopenia during radiotherapy in patients with oropharyngeal cancer.
Ng SP, Bahig H, Jethanandani A, Pollard C, Berends J, Sturgis EM, Johnson FM, Elgohari B, Elhalawani H, Rosenthal DI, Skinner HD, Gunn GB, Phan J, Frank SJ, Mohamed ASR, Fuller CD, Garden AS
Radiother Oncol 2020 Apr;145:95-100. Epub 2020 Jan 10 doi: 10.1016/j.radonc.2019.12.023. PMID: 31931292Free PMC Article

Clinical prediction guides

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality.
Rejeski K, Wang Y, Hansen DK, Iacoboni G, Bachy E, Bansal R, Penack O, Müller F, Bethge W, Munoz J, Mohty R, Bücklein VL, Barba P, Locke FL, Lin Y, Jain MD, Subklewe M
Blood Adv 2024 Apr 23;8(8):1857-1868. doi: 10.1182/bloodadvances.2023011767. PMID: 38181508Free PMC Article
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients.
Ahmadvand M, Barough MS, Barkhordar M, Faridfar A, Ghaderi A, Jalaeikhoo H, Rajaienejad M, Majidzadeh K, Ghavamzadeh A, Sarrami-Forooshani R
BMC Cancer 2023 Nov 10;23(1):1090. doi: 10.1186/s12885-023-11610-x. PMID: 37950209Free PMC Article
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas.
Tschernia NP, Heiling H, Deal AM, Cheng C, Babinec C, Gonzalez M, Morrison JK, Dittus C, Dotti G, Beaven AW, Serody JS, Wood WA, Savoldo B, Grover NS
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-006959. PMID: 37527906Free PMC Article
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.
Ghilardi G, Chong EA, Svoboda J, Wohlfarth P, Nasta SD, Williamson S, Landsburg JD, Gerson JN, Barta SK, Pajarillo R, Myers J, Chen AI, Schachter L, Yelton R, Ballard HJ, Hodges Dwinal A, Gier S, Victoriano D, Weber E, Napier E, Garfall A, Porter DL, Jäger U, Maziarz RT, Ruella M, Schuster SJ
Ann Oncol 2022 Sep;33(9):916-928. Epub 2022 Jun 9 doi: 10.1016/j.annonc.2022.05.521. PMID: 35690221Free PMC Article
Treatment of a first patient with FLASH-radiotherapy.
Bourhis J, Sozzi WJ, Jorge PG, Gaide O, Bailat C, Duclos F, Patin D, Ozsahin M, Bochud F, Germond JF, Moeckli R, Vozenin MC
Radiother Oncol 2019 Oct;139:18-22. Epub 2019 Jul 11 doi: 10.1016/j.radonc.2019.06.019. PMID: 31303340

Recent systematic reviews

Daratumumab and antineoplastic therapy versus antineoplastic therapy only for adults with newly diagnosed multiple myeloma ineligible for transplant.
Langer P, John L, Monsef I, Scheid C, Piechotta V, Skoetz N
Cochrane Database Syst Rev 2024 May 2;5(5):CD013595. doi: 10.1002/14651858.CD013595.pub2. PMID: 38695605Free PMC Article
Upfront autologous hematopoietic stem cell transplantation consolidation for patients with aggressive B-cell lymphomas in first remission in the rituximab era: A systematic review and meta-analysis.
Epperla N, Hamadani M, Reljic T, Kharfan-Dabaja MA, Savani BN, Kumar A
Cancer 2019 Dec 15;125(24):4417-4425. Epub 2019 Aug 23 doi: 10.1002/cncr.32464. PMID: 31441943
Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders.
Gu Y, Estcourt LJ, Doree C, Hopewell S, Vyas P
Cochrane Database Syst Rev 2015 Oct 5;2015(10):CD011577. doi: 10.1002/14651858.CD011577.pub2. PMID: 26436602Free PMC Article

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