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Neonatal Culture Negative Sepsis, AE

MedGen UID:
1669565
•Concept ID:
C4743797
•
Finding
Synonym: Neonatal Culture Negative Sepsis, Adverse Event

Definition

An adverse event in a newborn characterized by a systemic inflammatory response without identifiable cause. [from NCI]

Professional guidelines

PubMed

The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Pentoxifylline Treatment of Very Low Birth Weight Neonates with Nosocomial Sepsis.
Hamilçıkan Ş, Can E, Büke Ö, Erol M, Gayret ÖB
Am J Perinatol 2017 Jul;34(8):795-800. Epub 2017 Feb 14 doi: 10.1055/s-0037-1598596. PMID: 28196391
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent clinical studies

Etiology

Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis.
Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Van Wickle K, Abayneh M, Metaferia G, Carvalho MJ, Thomson K, Sands K, Walsh TR, Milton R, Goddard FGB, Bekele D, Chan GJ
PLoS One 2021;16(8):e0255410. Epub 2021 Aug 3 doi: 10.1371/journal.pone.0255410. PMID: 34343185Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779
Liver abscess in neonates.
Simeunovic E, Arnold M, Sidler D, Moore SW
Pediatr Surg Int 2009 Feb;25(2):153-6. Epub 2008 Dec 17 doi: 10.1007/s00383-008-2307-5. PMID: 19089433
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Diagnosis

Bad bugs: antibiotic-resistant bacteriuria in pregnancy and risk of pyelonephritis.
Denoble A, Reid HW, Krischak M, Rosett H, Sachdeva S, Weaver K, Heine PR, Dotters-Katz S
Am J Obstet Gynecol MFM 2022 Mar;4(2):100540. Epub 2021 Nov 29 doi: 10.1016/j.ajogmf.2021.100540. PMID: 34856419Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779
Liver abscess in neonates.
Simeunovic E, Arnold M, Sidler D, Moore SW
Pediatr Surg Int 2009 Feb;25(2):153-6. Epub 2008 Dec 17 doi: 10.1007/s00383-008-2307-5. PMID: 19089433
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Therapy

Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779
Liver abscess in neonates.
Simeunovic E, Arnold M, Sidler D, Moore SW
Pediatr Surg Int 2009 Feb;25(2):153-6. Epub 2008 Dec 17 doi: 10.1007/s00383-008-2307-5. PMID: 19089433
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Prognosis

Ten- vs. 14-day antibiotic therapy for culture-positive neonatal sepsis.
Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K
J Trop Pediatr 2023 Oct 5;69(6) doi: 10.1093/tropej/fmad036. PMID: 37986651
The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Late-onset bloodstream infections in hospitalized term infants.
Testoni D, Hayashi M, Cohen-Wolkowiez M, Benjamin DK Jr, Lopes RD, Clark RH, Benjamin DK, Smith PB
Pediatr Infect Dis J 2014 Sep;33(9):920-3. doi: 10.1097/INF.0000000000000322. PMID: 24618934Free PMC Article
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779
Intravenous catheter-related infections.
Salzman MB, Rubin LG
Adv Pediatr Infect Dis 1995;10:337-68. PMID: 7718211

Clinical prediction guides

Surgery-Associated Infections among Infants Born Extremely Preterm.
Shane AL, Hansen NI, Moallem M, Wyckoff MH, Sánchez PJ, Stoll BJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
J Pediatr 2022 Jan;240:58-65.e6. Epub 2021 Aug 27 doi: 10.1016/j.jpeds.2021.08.064. PMID: 34461060Free PMC Article
Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
A review of umbilical venous catheter-related complications at a tertiary neonatal unit in Singapore.
Goh SSM, Kan SY, Bharadwaj S, Poon WB
Singapore Med J 2021 Jan;62(1):29-33. Epub 2019 Nov 4 doi: 10.11622/smedj.2019140. PMID: 33619572Free PMC Article
The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review.
Viel-Theriault I, Fell DB, Grynspan D, Redpath S, Thampi N
Early Hum Dev 2019 Aug;135:6-10. Epub 2019 Jun 6 doi: 10.1016/j.earlhumdev.2019.05.020. PMID: 31177037
Management of neonates with suspected or proven early-onset bacterial sepsis.
Polin RA; Committee on Fetus and Newborn
Pediatrics 2012 May;129(5):1006-15. Epub 2012 Apr 30 doi: 10.1542/peds.2012-0541. PMID: 22547779

Recent systematic reviews

Antibiotic regimens for late-onset neonatal sepsis.
Korang SK, Safi S, Nava C, Greisen G, Gupta M, Lausten-Thomsen U, Jakobsen JC
Cochrane Database Syst Rev 2021 May 8;5(5):CD013836. doi: 10.1002/14651858.CD013836.pub2. PMID: 33998665Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical artery catheters.
Inglis GD, Jardine LA, Davies MW
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD004697. doi: 10.1002/14651858.CD004697.pub3. PMID: 17943827Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infants.
Inglis GD, Jardine LA, Davies MW
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004338. doi: 10.1002/14651858.CD004338.pub3. PMID: 17636752Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical venous catheters.
Inglis GD, Davies MW
Cochrane Database Syst Rev 2005 Oct 19;2005(4):CD005251. doi: 10.1002/14651858.CD005251.pub2. PMID: 16235397Free PMC Article
Prophylactic antibiotics to reduce morbidity and mortality in ventilated newborn infants.
Inglis GD, Davies MW
Cochrane Database Syst Rev 2004;(1):CD004338. doi: 10.1002/14651858.CD004338.pub2. PMID: 14974065

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