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Weight Loss, CTCAE

MedGen UID:
416251
•Concept ID:
C2911645
•
Finding

Definition

A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve. [from NCI]

Professional guidelines

PubMed

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Does nutritional status affect treatment tolerability, chemotherapy response and survival in metastatic gastric cancer patients? Results of a prospective multicenter study in Turkey.
Karabulut S, Dogan I, Usul Afsar C, Karabulut M, Ak N, Duran A, Tastekin D
J Oncol Pharm Pract 2022 Jan;28(1):127-134. Epub 2021 Jan 12 doi: 10.1177/1078155220987291. PMID: 33435820
Does nutritional status affect treatment tolarability, response and survival in metastatic colorectal cancer patients? Results of a prospective multicenter study.
Karabulut S, Dogan I, Usul Afsar C, Karabulut M, Karaman S, Ferhatoglu F, Tastekin D
J Oncol Pharm Pract 2021 Sep;27(6):1357-1363. Epub 2020 Sep 22 doi: 10.1177/1078155220959427. PMID: 32957862

Recent clinical studies

Etiology

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low- to intermediate-risk oropharyngeal squamous cell carcinoma.
Heah H, Goepfert RP, Hutcheson KA, Garden AS, Gunn GB, Fuller CD, Lewin JS, Kupferman ME, Holsinger FC, Hessel AC, Gross ND
Head Neck 2018 Nov;40(11):2507-2513. Epub 2018 Aug 13 doi: 10.1002/hed.25382. PMID: 30102824
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Diagnosis

Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.
Barnabei A, Strigari L, Corsello A, Paragliola RM, Iannantuono GM, Salvatori R, Corsello SM, Torino F
Front Endocrinol (Lausanne) 2022;13:840971. Epub 2022 Mar 21 doi: 10.3389/fendo.2022.840971. PMID: 35388297Free PMC Article
Does nutritional status affect treatment tolerability, chemotherapy response and survival in metastatic gastric cancer patients? Results of a prospective multicenter study in Turkey.
Karabulut S, Dogan I, Usul Afsar C, Karabulut M, Ak N, Duran A, Tastekin D
J Oncol Pharm Pract 2022 Jan;28(1):127-134. Epub 2021 Jan 12 doi: 10.1177/1078155220987291. PMID: 33435820
Early morbidity and dose-volume effects in definitive radiochemotherapy for locally advanced cervical cancer: a prospective cohort study covering modern treatment techniques.
Seppenwoolde Y, Majercakova K, Buschmann M, Dörr E, Sturdza AE, Schmid MP, Pötter R, Georg D
Strahlenther Onkol 2021 Jun;197(6):505-519. Epub 2021 Apr 30 doi: 10.1007/s00066-021-01781-6. PMID: 33929558Free PMC Article
Oral examination findings, taste and smell testing during and following head and neck cancer therapy.
Epstein JB, Villines D, Epstein GL, Smutzer G
Support Care Cancer 2020 Sep;28(9):4305-4311. Epub 2020 Jan 7 doi: 10.1007/s00520-019-05232-y. PMID: 31912362
Acute toxicity in nasopharyngeal carcinoma patients treated with IMRT/VMAT.
Ozdemir S, Akin M, Coban Y, Yildirim C, Uzel O
Asian Pac J Cancer Prev 2015;16(5):1897-900. doi: 10.7314/apjcp.2015.16.5.1897. PMID: 25773841

Therapy

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task.
Barnabei A, Strigari L, Corsello A, Paragliola RM, Iannantuono GM, Salvatori R, Corsello SM, Torino F
Front Endocrinol (Lausanne) 2022;13:840971. Epub 2022 Mar 21 doi: 10.3389/fendo.2022.840971. PMID: 35388297Free PMC Article
Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity.
Iwata H, Toshito T, Hayashi K, Yamada M, Omachi C, Nakajima K, Hattori Y, Hashimoto S, Kuroda Y, Okumura Y, Mizoe JE, Ogino H, Shibamoto Y
J Radiat Res 2019 Oct 23;60(5):612-621. doi: 10.1093/jrr/rrz036. PMID: 31147697Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584

Prognosis

Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low- to intermediate-risk oropharyngeal squamous cell carcinoma.
Heah H, Goepfert RP, Hutcheson KA, Garden AS, Gunn GB, Fuller CD, Lewin JS, Kupferman ME, Holsinger FC, Hessel AC, Gross ND
Head Neck 2018 Nov;40(11):2507-2513. Epub 2018 Aug 13 doi: 10.1002/hed.25382. PMID: 30102824
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

Clinical prediction guides

Adverse events and oncologic outcomes with combination lenvatinib and pembrolizumab for the treatment of recurrent endometrial cancer.
Zammarrelli WA 3rd, Ma W, Espino K, Gordhandas S, Yeoshoua E, Ehmann S, Zhou Q, Iasonos A, Abu-Rustum NR, Aghajanian C, Green AK, Rubinstein MM, Makker V
Gynecol Oncol 2023 Nov;178:27-35. Epub 2023 Sep 23 doi: 10.1016/j.ygyno.2023.09.010. PMID: 37748268Free PMC Article
Weight loss in nintedanib-treated patients with idiopathic pulmonary fibrosis.
Tomioka H, Iwabayashi M, Yokota M, Hashimoto R, Amimoto H
Pulm Pharmacol Ther 2023 Jun;80:102213. Epub 2023 Mar 29 doi: 10.1016/j.pupt.2023.102213. PMID: 37001796
Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.
Holmqvist A, Lindahl G, Mikivier R, Uppungunduri S
BMC Cancer 2022 Apr 7;22(1):371. doi: 10.1186/s12885-022-09480-w. PMID: 35392858Free PMC Article
Stomach Dose-Volume Predicts Acute Gastrointestinal Toxicity in Chemoradiotherapy for Locally Advanced Pancreatic Cancer.
Holyoake DLP, Warren DR, Hurt C, Aznar M, Partridge M, Mukherjee S, Hawkins MA
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):418-426. Epub 2018 Mar 28 doi: 10.1016/j.clon.2018.02.067. PMID: 29602584
Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system.
Palazzi M, Tomatis S, Orlandi E, Guzzo M, Sangalli C, Potepan P, Fantini S, Bergamini C, Gavazzi C, Licitra L, Scaramellini G, Cantu' G, Olmi P
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):330-7. Epub 2007 Sep 19 doi: 10.1016/j.ijrobp.2007.06.022. PMID: 17881148

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