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Hypoxic Ischemic Encephalopathy, AE

MedGen UID:
1655934
Concept ID:
C4724158
Finding
Synonym: Hypoxic Ischemic Encephalopathy, Adverse Event

Definition

An adverse event in a newborn characterized by injury to the central nervous system that occurs when there is insufficient delivery of oxygen to all or part of the brain. [from NCI]

Professional guidelines

PubMed

Zhou J, Gao T, Tang W, Qian T, Wang Z, Xu P, Wang L
Brain Dev 2023 Nov;45(10):533-546. Epub 2023 Oct 6 doi: 10.1016/j.braindev.2023.09.001. PMID: 37806836
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article
Pinchefsky EF, Schneider J, Basu S, Tam EWY, Gale C; Newborn Brain Society Guidelines and Publications Committee*
Semin Fetal Neonatal Med 2021 Aug;26(4):101268. Epub 2021 Jul 13 doi: 10.1016/j.siny.2021.101268. PMID: 34301501

Recent clinical studies

Etiology

Khanduja S, Kim J, Kang JK, Feng CY, Vogelsong MA, Geocadin RG, Whitman G, Cho SM
Cells 2023 Jun 5;12(11) doi: 10.3390/cells12111546. PMID: 37296666Free PMC Article
Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Modabbernia A, Velthorst E, Reichenberg A
Mol Autism 2017;8:13. Epub 2017 Mar 17 doi: 10.1186/s13229-017-0121-4. PMID: 28331572Free PMC Article
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network
N Engl J Med 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929. PMID: 16221780

Diagnosis

Ledgerwood C, Villgran V, Mardirossian N, Dumont T, DiSilvio B
Crit Care Nurs Q 2022 Jul-Sep 01;45(3):248-257. doi: 10.1097/CNQ.0000000000000409. PMID: 35617091
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article
van Cuilenborg VR, Hermanides J, Bos EME Drs, Hollmann MW, Preckel B, Kooij FO, Terreehorst I
Best Pract Res Clin Anaesthesiol 2021 May;35(1):11-25. Epub 2020 Apr 3 doi: 10.1016/j.bpa.2020.03.003. PMID: 33742571
Nestaas E, Walsh BH
Clin Perinatol 2020 Sep;47(3):575-592. Epub 2020 May 21 doi: 10.1016/j.clp.2020.05.012. PMID: 32713452
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437

Therapy

Khanduja S, Kim J, Kang JK, Feng CY, Vogelsong MA, Geocadin RG, Whitman G, Cho SM
Cells 2023 Jun 5;12(11) doi: 10.3390/cells12111546. PMID: 37296666Free PMC Article
Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Silveira RC, Procianoy RS
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S78-83. Epub 2015 Sep 4 doi: 10.1016/j.jped.2015.07.004. PMID: 26354871
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network
N Engl J Med 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929. PMID: 16221780

Prognosis

Wang Z, Zhang D, Zhang P, Zhou W, Hu L, Wang L, Cheng G
BMC Pediatr 2023 Oct 26;23(1):530. doi: 10.1186/s12887-023-04365-8. PMID: 37884911Free PMC Article
Wennerholm UB, Saltvedt S, Wessberg A, Alkmark M, Bergh C, Wendel SB, Fadl H, Jonsson M, Ladfors L, Sengpiel V, Wesström J, Wennergren G, Wikström AK, Elden H, Stephansson O, Hagberg H
BMJ 2019 Nov 20;367:l6131. doi: 10.1136/bmj.l6131. PMID: 31748223Free PMC Article
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437
Busl KM, Greer DM
NeuroRehabilitation 2010;26(1):5-13. doi: 10.3233/NRE-2010-0531. PMID: 20130351
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network
N Engl J Med 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929. PMID: 16221780

Clinical prediction guides

Kumar J, Anne RP, Meena J, Sundaram V, Dutta S, Kumar P
Eur J Pediatr 2023 Jun;182(6):2759-2773. Epub 2023 Apr 4 doi: 10.1007/s00431-023-04950-0. PMID: 37014443
Ojha S, Abramson J, Dorling J
BMJ Paediatr Open 2022 May;6(1) doi: 10.1136/bmjpo-2022-001460. PMID: 36053596Free PMC Article
Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium
N Engl J Med 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660. PMID: 35830641Free PMC Article
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437

Recent systematic reviews

Kumar J, Anne RP, Meena J, Sundaram V, Dutta S, Kumar P
Eur J Pediatr 2023 Jun;182(6):2759-2773. Epub 2023 Apr 4 doi: 10.1007/s00431-023-04950-0. PMID: 37014443
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article
Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA
Arch Pediatr Adolesc Med 2012 Jun 1;166(6):558-66. doi: 10.1001/archpediatrics.2011.1772. PMID: 22312166
Shah PS, Ohlsson A, Perlman M
Arch Pediatr Adolesc Med 2007 Oct;161(10):951-8. doi: 10.1001/archpedi.161.10.951. PMID: 17909138

Supplemental Content

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