U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Urothelial carcinoma

MedGen UID:
760495
Concept ID:
C2145472
Neoplastic Process
Synonyms: transitional cell car. -uroth.; Transitional Cell Carcinoma of the Urinary Tract; transitional cell carcinoma of the urinary tract; transitional cell carcinoma of the urothelial tract; Uroepithelial Carcinoma; Uroepithelial carcinoma; Urothelial Carcinoma; urothelial carcinoma
 
Monarch Initiative: MONDO:0040679

Definition

A carcinoma arising from the urothelial lining of the urinary tract (bladder, renal pelvis, ureter, or urethra). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrothelial carcinoma

Professional guidelines

PubMed

Powles T, Bellmunt J, Comperat E, De Santis M, Huddart R, Loriot Y, Necchi A, Valderrama BP, Ravaud A, Shariat SF, Szabados B, van der Heijden MS, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Mar;33(3):244-258. Epub 2021 Nov 30 doi: 10.1016/j.annonc.2021.11.012. PMID: 34861372
Wong JL, Rosenberg JE
Expert Opin Biol Ther 2021 Jul;21(7):863-873. Epub 2021 May 24 doi: 10.1080/14712598.2021.1929168. PMID: 34030536Free PMC Article
Patel VG, Oh WK, Galsky MD
CA Cancer J Clin 2020 Sep;70(5):404-423. Epub 2020 Aug 7 doi: 10.3322/caac.21631. PMID: 32767764

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

Recent clinical studies

Etiology

Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Thomas J, Sun M, Getz T, Ho B, Nauseef JT, Tagawa ST
Urol Oncol 2023 Oct;41(10):420-428. Epub 2023 Jul 6 doi: 10.1016/j.urolonc.2023.06.006. PMID: 37419845
Joseph JP, O'Malley P, Su LM
J Endourol 2021 Sep;35(S2):S122-S131. doi: 10.1089/end.2020.1074. PMID: 34499556
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959

Diagnosis

Gandhi J, Chen JF, Al-Ahmadie H
Surg Pathol Clin 2022 Dec;15(4):641-659. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.003. PMID: 36344181Free PMC Article
Knowles M, Dyrskjøt L, Heath EI, Bellmunt J, Siefker-Radtke AO
Cancer Cell 2021 May 10;39(5):583-585. doi: 10.1016/j.ccell.2021.04.012. PMID: 33974855
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497
Froemming A, Potretzke T, Takahashi N, Kim B
Eur J Radiol 2018 Jan;98:50-60. Epub 2017 Nov 8 doi: 10.1016/j.ejrad.2017.10.021. PMID: 29279170
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959

Therapy

van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators
N Engl J Med 2023 Nov 9;389(19):1778-1789. Epub 2023 Oct 22 doi: 10.1056/NEJMoa2309863. PMID: 37870949
Loriot Y, Matsubara N, Park SH, Huddart RA, Burgess EF, Houede N, Banek S, Guadalupi V, Ku JH, Valderrama BP, Tran B, Triantos S, Kean Y, Akapame S, Deprince K, Mukhopadhyay S, Stone NL, Siefker-Radtke AO; THOR Cohort 1 Investigators
N Engl J Med 2023 Nov 23;389(21):1961-1971. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2308849. PMID: 37870920
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Patel VG, Oh WK, Galsky MD
CA Cancer J Clin 2020 Sep;70(5):404-423. Epub 2020 Aug 7 doi: 10.3322/caac.21631. PMID: 32767764

Prognosis

Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Balar AV, Castellano DE, Grivas P, Vaughn DJ, Powles T, Vuky J, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Necchi A, Petrylak DP, Plimack ER, Xu JZ, Imai K, Moreno BH, Bellmunt J, de Wit R, O'Donnell PH
Ann Oncol 2023 Mar;34(3):289-299. Epub 2022 Dec 6 doi: 10.1016/j.annonc.2022.11.012. PMID: 36494006
Lobo N, Afferi L, Moschini M, Mostafid H, Porten S, Psutka SP, Gupta S, Smith AB, Williams SB, Lotan Y
Eur Urol Oncol 2022 Dec;5(6):628-639. Epub 2022 Nov 1 doi: 10.1016/j.euo.2022.10.003. PMID: 36333236
Powles T, Bellmunt J, Comperat E, De Santis M, Huddart R, Loriot Y, Necchi A, Valderrama BP, Ravaud A, Shariat SF, Szabados B, van der Heijden MS, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Mar;33(3):244-258. Epub 2021 Nov 30 doi: 10.1016/j.annonc.2021.11.012. PMID: 34861372
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713

Clinical prediction guides

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Lopez-Beltran A, Cimadamore A, Montironi R, Cheng L
Hum Pathol 2021 Jul;113:67-83. Epub 2021 Apr 19 doi: 10.1016/j.humpath.2021.04.001. PMID: 33887300
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Xing J, Reynolds JP
Surg Pathol Clin 2018 Sep;11(3):601-610. Epub 2018 Jul 13 doi: 10.1016/j.path.2018.06.001. PMID: 30190143
Malayeri AA, Pattanayak P, Apolo AB
Curr Opin Urol 2015 Sep;25(5):441-8. doi: 10.1097/MOU.0000000000000208. PMID: 26222929Free PMC Article

Recent systematic reviews

Bouleftour W, Guillot A, Magne N
Mol Cancer Ther 2022 Apr 1;21(4):493-501. doi: 10.1158/1535-7163.MCT-21-0846. PMID: 35131876
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Sylvester RJ, Oosterlinck W, Holmang S, Sydes MR, Birtle A, Gudjonsson S, De Nunzio C, Okamura K, Kaasinen E, Solsona E, Ali-El-Dein B, Tatar CA, Inman BA, N'Dow J, Oddens JR, Babjuk M
Eur Urol 2016 Feb;69(2):231-44. Epub 2015 Jun 16 doi: 10.1016/j.eururo.2015.05.050. PMID: 26091833

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...