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Bladder urachal urothelial carcinoma

MedGen UID:
267744
•Concept ID:
C1511207
•
Neoplastic Process
Synonyms: Bladder Urachal Urothelial Carcinoma; bladder urachal urothelial carcinoma; Urachal Urothelial Carcinoma
 
Monarch Initiative: MONDO:0004163

Definition

A urothelial carcinoma of the urinary bladder that arises from the urachal epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder urachal urothelial carcinoma

Professional guidelines

PubMed

Current Advances in the Management of Nonurothelial Subtypes of Bladder Cancer.
Vlachou E, Johnson BA 3rd, Baraban E, Nadal R, Hoffman-Censits J
Am Soc Clin Oncol Educ Book 2024 Jun;44(3):e438640. doi: 10.1200/EDBK_438640. PMID: 38870453
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748
Urachal adenocarcinoma: a clinician's guide for treatment.
Siefker-Radtke A
Semin Oncol 2012 Oct;39(5):619-24. doi: 10.1053/j.seminoncol.2012.08.011. PMID: 23040259

Recent clinical studies

Etiology

Preoperative accuracy of diagnostic evaluation of urachal carcinoma.
Ke C, Hu Z, Yang C
Cancer Med 2023 Apr;12(8):9106-9115. Epub 2023 Feb 3 doi: 10.1002/cam4.5648. PMID: 36734315Free PMC Article
Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype.
Almassi N, Whiting K, Toubaji A, Lenis AT, Jordan EJ, Won H, Regazzi AM, Chen YB, Gopalan A, Sirintrapun SJ, Fine SW, Tickoo SK, Ostrovnaya I, Pietzak EJ, Cha EK, Goh AC, Donahue TF, Herr HW, Donat SM, Dalbagni G, Bochner BH, Teo MY, Funt SA, Rosenberg JE, Reuter VE, Bajorin DF, Solit DB, Al-Ahmadie H, Iyer G
JCO Precis Oncol 2022 Jun;6:e2100392. doi: 10.1200/PO.21.00392. PMID: 35731998Free PMC Article
A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306
Urachal remnants: an enigma.
Upadhyay V, Kukkady A
Eur J Pediatr Surg 2003 Dec;13(6):372-6. doi: 10.1055/s-2003-44725. PMID: 14743323

Diagnosis

Urachal cancer-current concepts of a rare cancer.
Reis H, Szarvas T
Pathologe 2019 Jun;40(Suppl 1):31-39. doi: 10.1007/s00292-018-0516-9. PMID: 30895340
Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306
Lower tract neoplasm: Update of imaging evaluation.
Hartman R, Kawashima A
Eur J Radiol 2017 Dec;97:119-130. doi: 10.1016/j.ejrad.2017.10.019. PMID: 29102424
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Urachal remnants: an enigma.
Upadhyay V, Kukkady A
Eur J Pediatr Surg 2003 Dec;13(6):372-6. doi: 10.1055/s-2003-44725. PMID: 14743323

Therapy

Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors.
Apolo AB, Girardi DM, Niglio SA, Nadal R, Kydd AR, Simon N, Ley L, Cordes LM, Chandran E, Steinberg SM, Lee S, Lee MJ, Rastogi S, Sato N, Cao L, Banday AR, Boudjadi S, Merino MJ, Toubaji A, Akbulut D, Redd B, Bagheri H, Costello R, Gurram S, Agarwal PK, Chalfin HJ, Valera V, Streicher H, Wright JJ, Sharon E, Figg WD, Parnes HL, Gulley JL, Saraiya B, Pal SK, Quinn D, Stein MN, Lara PN, Bottaro DP, Mortazavi A
J Clin Oncol 2024 Sep 1;42(25):3033-3046. Epub 2024 Jul 2 doi: 10.1200/JCO.23.02233. PMID: 38954785Free PMC Article
Urachal carcinoma: A case of a rare neoplasm.
Moreira I, Coelho S, Rodrigues Â, Patrão AS, Maurício MJ
Curr Probl Cancer 2021 Dec;45(6):100711. Epub 2021 Jan 28 doi: 10.1016/j.currproblcancer.2021.100711. PMID: 33541722
A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Urachal adenocarcinoma: a clinician's guide for treatment.
Siefker-Radtke A
Semin Oncol 2012 Oct;39(5):619-24. doi: 10.1053/j.seminoncol.2012.08.011. PMID: 23040259
Urachal carcinoma: surgical and chemotherapeutic options.
Siefker-Radtke A
Expert Rev Anticancer Ther 2006 Dec;6(12):1715-21. doi: 10.1586/14737140.6.12.1715. PMID: 17181485

Prognosis

Preoperative accuracy of diagnostic evaluation of urachal carcinoma.
Ke C, Hu Z, Yang C
Cancer Med 2023 Apr;12(8):9106-9115. Epub 2023 Feb 3 doi: 10.1002/cam4.5648. PMID: 36734315Free PMC Article
Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306
Lower tract neoplasm: Update of imaging evaluation.
Hartman R, Kawashima A
Eur J Radiol 2017 Dec;97:119-130. doi: 10.1016/j.ejrad.2017.10.019. PMID: 29102424
Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis.
Niedworok C, Panitz M, Szarvas T, Reis H, Reis AC, Szendröi A, Nyirády P, Szasz AM, Módos O, Rübben H, Vom Dorp F
J Urol 2016 Jun;195(6):1690-6. Epub 2015 Dec 8 doi: 10.1016/j.juro.2015.11.067. PMID: 26678957
Urachal remnants: an enigma.
Upadhyay V, Kukkady A
Eur J Pediatr Surg 2003 Dec;13(6):372-6. doi: 10.1055/s-2003-44725. PMID: 14743323

Clinical prediction guides

Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype.
Almassi N, Whiting K, Toubaji A, Lenis AT, Jordan EJ, Won H, Regazzi AM, Chen YB, Gopalan A, Sirintrapun SJ, Fine SW, Tickoo SK, Ostrovnaya I, Pietzak EJ, Cha EK, Goh AC, Donahue TF, Herr HW, Donat SM, Dalbagni G, Bochner BH, Teo MY, Funt SA, Rosenberg JE, Reuter VE, Bajorin DF, Solit DB, Al-Ahmadie H, Iyer G
JCO Precis Oncol 2022 Jun;6:e2100392. doi: 10.1200/PO.21.00392. PMID: 35731998Free PMC Article
A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis.
Niedworok C, Panitz M, Szarvas T, Reis H, Reis AC, Szendröi A, Nyirády P, Szasz AM, Módos O, Rübben H, Vom Dorp F
J Urol 2016 Jun;195(6):1690-6. Epub 2015 Dec 8 doi: 10.1016/j.juro.2015.11.067. PMID: 26678957
Cystoscopic findings: a video tutorial.
Lenherr SM, Crosby EC, Cameron AP
Int Urogynecol J 2015 Jun;26(6):921-3. Epub 2015 Jan 27 doi: 10.1007/s00192-014-2614-4. PMID: 25619539Free PMC Article
Urachal carcinoma: surgical and chemotherapeutic options.
Siefker-Radtke A
Expert Rev Anticancer Ther 2006 Dec;6(12):1715-21. doi: 10.1586/14737140.6.12.1715. PMID: 17181485

Recent systematic reviews

Estimation of the incidence of urachal cancer: A systematic review and meta-analysis of registry-based studies.
Olah C, Kubik A, Mátrai P, Engh MA, Barna V, Hegyi P, Reis H, Nyirády P, Szarvas T
Urol Oncol 2024 Jul;42(7):221.e1-221.e7. Epub 2024 Apr 15 doi: 10.1016/j.urolonc.2024.03.011. PMID: 38627107

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