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Kidney pelvis sarcomatoid transitional cell carcinoma

MedGen UID:
233403
•Concept ID:
C1335752
•
Neoplastic Process
Synonyms: Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant; infiltrating renal pelvis urothelial carcinoma, sarcomatoid variant; Invasive Renal Pelvis Sarcomatoid Urothelial Carcinoma; Invasive Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant; Kidney Pelvis Sarcomatoid Transitional Cell Carcinoma; kidney pelvis sarcomatoid transitional cell carcinoma; renal pelvis sarcomatoid transitional cell carcinoma; Sarcomatoid Transitional Cell Carcinoma of Kidney Pelvis; sarcomatoid transitional cell carcinoma of kidney pelvis; Sarcomatoid Transitional Cell Carcinoma of Renal Pelvis; sarcomatoid transitional cell carcinoma of renal pelvis; Sarcomatoid Transitional Cell Carcinoma of the Kidney Pelvis; sarcomatoid transitional cell carcinoma of the kidney pelvis; Sarcomatoid Transitional Cell Carcinoma of the Renal Pelvis; sarcomatoid transitional cell carcinoma of the renal pelvis
 
Monarch Initiative: MONDO:0004009

Definition

An invasive urothelial carcinoma that arises from the renal pelvis and exhibits sarcomatoid features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney pelvis sarcomatoid transitional cell carcinoma

Recent clinical studies

Etiology

Comprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy.
Hacking SM, Pavlick D, Wang Y, Carneiro BA, Mullally M, Lu S, Canepa M, Bratslavsky G, Jacob J, Necchi A, Spiess PE, Wang L, Yakirevich E, Ross J
Oncologist 2023 Jul 5;28(7):e508-e519. doi: 10.1093/oncolo/oyad040. PMID: 36917021Free PMC Article
Urothelial cancer of the renal pelvis in percutaneous nephrolithotomy patients.
Katz R, Gofrit ON, Golijanin D, Landau EH, Shapiro A, Pode D, Meretyk S
Urol Int 2005;75(1):17-20. doi: 10.1159/000085921. PMID: 16037702
Sarcomatoid transitional cell carcinomas of the renal pelvis. An ultrastructural and immunohistochemical study.
Wick MR, Perrone TL, Burke BA
Arch Pathol Lab Med 1985 Jan;109(1):55-8. PMID: 3882075

Diagnosis

Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy.
Anraku T, Hashidate H, Nakahara A, Imai T, Kawakami Y
BMC Urol 2023 Mar 18;23(1):38. doi: 10.1186/s12894-023-01210-z. PMID: 36934227Free PMC Article
Comprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy.
Hacking SM, Pavlick D, Wang Y, Carneiro BA, Mullally M, Lu S, Canepa M, Bratslavsky G, Jacob J, Necchi A, Spiess PE, Wang L, Yakirevich E, Ross J
Oncologist 2023 Jul 5;28(7):e508-e519. doi: 10.1093/oncolo/oyad040. PMID: 36917021Free PMC Article
Sarcomatoid variant of urothelial carcinoma in the renal pelvis with brain metastasis: a case report.
Nasrollahi H, Ahmed F, Eslahi A, Pilehroud MG, Safaei A, Askarpour MR, Khorshidi A, Khorshidi S
Pan Afr Med J 2022;41:233. Epub 2022 Mar 22 doi: 10.11604/pamj.2022.41.233.31688. PMID: 35721650Free PMC Article
Clinical and histopathological features of carcinosarcoma of the renal pelvis: a systematic review of a rare tumor.
Mantica G, Benelli A, Ackermann H, Nxumalo Z, Solaiman A, Dotta F, van der Merwe A, Terrone C
Minerva Urol Nefrol 2019 Apr;71(2):121-126. Epub 2018 Sep 10 doi: 10.23736/S0393-2249.18.03192-2. PMID: 30203938
Unusual renal pelvic tumor containing transitional cell carcinoma, adenocarcinoma and sarcomatoid elements (so-called sarcomatoid carcinoma of the renal pelvis). A case report and review of the literature.
Tajima Y, Aizawa M
Acta Pathol Jpn 1988 Jun;38(6):805-14. doi: 10.1111/j.1440-1827.1988.tb02352.x. PMID: 2851258

Therapy

Clinical and histopathological features of carcinosarcoma of the renal pelvis: a systematic review of a rare tumor.
Mantica G, Benelli A, Ackermann H, Nxumalo Z, Solaiman A, Dotta F, van der Merwe A, Terrone C
Minerva Urol Nefrol 2019 Apr;71(2):121-126. Epub 2018 Sep 10 doi: 10.23736/S0393-2249.18.03192-2. PMID: 30203938

Prognosis

Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation.
Takemura K, Motoi T, Tonooka A, Funata N, Nakanishi Y, Kataoka M, Ito M, Sakamoto K, Suzuki H, Tobisu KI, Koga F
Int J Surg Pathol 2019 Aug;27(5):547-552. Epub 2019 Feb 15 doi: 10.1177/1066896919828111. PMID: 30767589
Urothelial cancer of the renal pelvis in percutaneous nephrolithotomy patients.
Katz R, Gofrit ON, Golijanin D, Landau EH, Shapiro A, Pode D, Meretyk S
Urol Int 2005;75(1):17-20. doi: 10.1159/000085921. PMID: 16037702
Molecular subclassification of kidney tumors and the discovery of new diagnostic markers.
Takahashi M, Yang XJ, Sugimura J, Backdahl J, Tretiakova M, Qian CN, Gray SG, Knapp R, Anema J, Kahnoski R, Nicol D, Vogelzang NJ, Furge KA, Kanayama H, Kagawa S, Teh BT
Oncogene 2003 Oct 2;22(43):6810-8. doi: 10.1038/sj.onc.1206869. PMID: 14555994

Clinical prediction guides

Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation.
Takemura K, Motoi T, Tonooka A, Funata N, Nakanishi Y, Kataoka M, Ito M, Sakamoto K, Suzuki H, Tobisu KI, Koga F
Int J Surg Pathol 2019 Aug;27(5):547-552. Epub 2019 Feb 15 doi: 10.1177/1066896919828111. PMID: 30767589
Molecular subclassification of kidney tumors and the discovery of new diagnostic markers.
Takahashi M, Yang XJ, Sugimura J, Backdahl J, Tretiakova M, Qian CN, Gray SG, Knapp R, Anema J, Kahnoski R, Nicol D, Vogelzang NJ, Furge KA, Kanayama H, Kagawa S, Teh BT
Oncogene 2003 Oct 2;22(43):6810-8. doi: 10.1038/sj.onc.1206869. PMID: 14555994
Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis.
Lopez-Beltran A, Escudero AL, Cavazzana AO, Spagnoli LG, Vicioso-Recio L
Pathol Res Pract 1996 Dec;192(12):1218-24. doi: 10.1016/S0344-0338(96)80154-3. PMID: 9182292
Sarcomatoid transitional cell carcinomas of the renal pelvis. An ultrastructural and immunohistochemical study.
Wick MR, Perrone TL, Burke BA
Arch Pathol Lab Med 1985 Jan;109(1):55-8. PMID: 3882075

Recent systematic reviews

Clinical and histopathological features of carcinosarcoma of the renal pelvis: a systematic review of a rare tumor.
Mantica G, Benelli A, Ackermann H, Nxumalo Z, Solaiman A, Dotta F, van der Merwe A, Terrone C
Minerva Urol Nefrol 2019 Apr;71(2):121-126. Epub 2018 Sep 10 doi: 10.23736/S0393-2249.18.03192-2. PMID: 30203938

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