U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Bladder Urothelial Carcinoma

MedGen UID:
1720059
•Concept ID:
C5235844
•
Neoplastic Process

Definition

Bladder urothelial carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Bladder Urothelial Carcinoma

Professional guidelines

PubMed

The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with Treatment Recommendations from the Spanish Oncology Genitourinary Group (SOGUG).
Font A, Luque R, Villa JC, Domenech M, Vázquez S, Gallardo E, Virizuela JA, Beato C, Morales-Barrera R, Gelabert A, Maciá S, Puente J, Rubio G, Maldonado X, Perez-Valderrama B, Pinto A, Fernández Calvo O, Grande E, Garde-Noguera J, Fernández-Parra E, Arranz JÁ
Target Oncol 2019 Feb;14(1):15-32. doi: 10.1007/s11523-019-00619-7. PMID: 30694442

Recent clinical studies

Etiology

Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma.
Loriot Y, Matsubara N, Park SH, Huddart RA, Burgess EF, Houede N, Banek S, Guadalupi V, Ku JH, Valderrama BP, Tran B, Triantos S, Kean Y, Akapame S, Deprince K, Mukhopadhyay S, Stone NL, Siefker-Radtke AO; THOR Cohort 1 Investigators
N Engl J Med 2023 Nov 23;389(21):1961-1971. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2308849. PMID: 37870920
Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study.
Siefker-Radtke AO, Necchi A, Park SH, García-Donas J, Huddart RA, Burgess EF, Fleming MT, Rezazadeh Kalebasty A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Akapame S, Santiago-Walker AE, Monga M, O'Hagan A, Loriot Y; BLC2001 Study Group
Lancet Oncol 2022 Feb;23(2):248-258. Epub 2022 Jan 11 doi: 10.1016/S1470-2045(21)00660-4. PMID: 35030333
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497

Diagnosis

First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma.
Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Urothelial Carcinoma: Divergent Differentiation and Morphologic Subtypes.
Gandhi J, Chen JF, Al-Ahmadie H
Surg Pathol Clin 2022 Dec;15(4):641-659. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.003. PMID: 36344181Free PMC Article
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497

Therapy

Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma.
Loriot Y, Matsubara N, Park SH, Huddart RA, Burgess EF, Houede N, Banek S, Guadalupi V, Ku JH, Valderrama BP, Tran B, Triantos S, Kean Y, Akapame S, Deprince K, Mukhopadhyay S, Stone NL, Siefker-Radtke AO; THOR Cohort 1 Investigators
N Engl J Med 2023 Nov 23;389(21):1961-1971. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2308849. PMID: 37870920
Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study.
Siefker-Radtke AO, Necchi A, Park SH, García-Donas J, Huddart RA, Burgess EF, Fleming MT, Rezazadeh Kalebasty A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Akapame S, Santiago-Walker AE, Monga M, O'Hagan A, Loriot Y; BLC2001 Study Group
Lancet Oncol 2022 Feb;23(2):248-258. Epub 2022 Jan 11 doi: 10.1016/S1470-2045(21)00660-4. PMID: 35030333
The biology and rationale of targeting nectin-4 in urothelial carcinoma.
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713

Prognosis

First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma.
Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
The biology and rationale of targeting nectin-4 in urothelial carcinoma.
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713
What Is the Significance of Variant Histology in Urothelial Carcinoma?
Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM
Eur Urol Focus 2020 Jul 15;6(4):653-663. Epub 2019 Sep 15 doi: 10.1016/j.euf.2019.09.003. PMID: 31530497

Clinical prediction guides

Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma.
Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, Li X, Li N, Zhang N, Zhu H, Yang Z, Sheng X, Yang X
Clin Cancer Res 2023 Sep 1;29(17):3395-3407. doi: 10.1158/1078-0432.CCR-23-0609. PMID: 37093191
Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease.
Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R
Nat Rev Urol 2023 Jul;20(7):406-419. Epub 2023 Mar 28 doi: 10.1038/s41585-023-00725-2. PMID: 36977797
Single-cell atlases link macrophages and CD8(+) T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma.
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Advances in bladder cancer biology and therapy.
Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D
Nat Rev Cancer 2021 Feb;21(2):104-121. Epub 2020 Dec 2 doi: 10.1038/s41568-020-00313-1. PMID: 33268841Free PMC Article

Recent systematic reviews

Immunotherapy for advanced or metastatic urothelial carcinoma: an abridged Cochrane review.
Maisch P, Hwang EC, Kim K, Narayan VM, Bakker C, Kunath F, Dahm P
BJU Int 2024 Oct;134(4):541-550. Epub 2024 Apr 24 doi: 10.1111/bju.16368. PMID: 38658182
Immunotherapy for advanced or metastatic urothelial carcinoma.
Maisch P, Hwang EC, Kim K, Narayan VM, Bakker C, Kunath F, Dahm P
Cochrane Database Syst Rev 2023 Oct 9;10(10):CD013774. doi: 10.1002/14651858.CD013774.pub2. PMID: 37811690Free PMC Article
Adjuvant Radiotherapy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Immuno-oncology therapy in metastatic bladder cancer: A systematic review and network meta-analysis.
Chierigo F, Wenzel M, Würnschimmel C, Flammia RS, Horlemann B, Tian Z, Saad F, Chun FKH, Tilki D, Shariat SF, Gallucci M, Borghesi M, Suardi N, Terrone C, Karakiewicz PI
Crit Rev Oncol Hematol 2022 Jan;169:103534. Epub 2021 Nov 22 doi: 10.1016/j.critrevonc.2021.103534. PMID: 34823022

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...