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Bladder Non-Invasive Papillary Urothelial Carcinoma

MedGen UID:
1684238
•Concept ID:
C4764210
•
Neoplastic Process

Definition

Papillary urothelial neoplastic proliferation in the bladder with some level of cytological and architectural disorder visible at low to intermediate magnification, with no invasion beyond the basement membrane (Ta). (WHO 2016) [from NCI]

Recent clinical studies

Etiology

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Diagnosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730

Therapy

Poncet's disease after the intravesical instillation of Bacillus Calmette-Guérin (BCG): a case report.
Sampaio PCM, Lira YG, Ribeiro HYU, de Paula Moreira F, Gadelha MSM, da Cruz SFS
BMC Res Notes 2017 Aug 18;10(1):416. doi: 10.1186/s13104-017-2606-9. PMID: 28821265Free PMC Article
Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder.
Reis LO, Taheri D, Chaux A, Guner G, Mendoza Rodriguez MA, Bivalacqua TJ, Schoenberg MP, Epstein JI, Netto GJ
Hum Pathol 2016 Jan;47(1):20-5. Epub 2015 Sep 25 doi: 10.1016/j.humpath.2015.09.007. PMID: 26520419
Pathology of carcinoma in situ of the urinary bladder and related lesions.
Farrow GM
J Cell Biochem Suppl 1992;16I:39-43. doi: 10.1002/jcb.240501308. PMID: 1305686

Prognosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Non-invasive papillary urothelial carcinoma with 'micropapillary' architecture: clinicopathological study of 18 patients emphasising clinical outcomes.
Sangoi AR, Cox RM, Higgins JP, Quick CM, McKenney JK
Histopathology 2020 Nov;77(5):728-733. Epub 2020 Sep 27 doi: 10.1111/his.14161. PMID: 32443178
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Pathology of upper tract urothelial carcinoma with emphasis on staging.
Mazzucchelli R, Scarpelli M, Galosi AB, Di Primio R, Lopez-Beltran A, Cheng L, Montironi R
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):509-16. doi: 10.1177/039463201402700406. PMID: 25572730
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Clinical prediction guides

High prevalence of p16 staining in malignant tumors.
De Wispelaere N, Rico SD, Bauer M, Luebke AM, Kluth M, Büscheck F, Hube-Magg C, Höflmayer D, Gorbokon N, Weidemann S, Möller K, Fraune C, Bernreuther C, Simon R, Kähler C, Menz A, Hinsch A, Jacobsen F, Lebok P, Clauditz T, Sauter G, Uhlig R, Wilczak W, Steurer S, Burandt E, Krech R, Dum D, Krech T, Marx A, Minner S
PLoS One 2022;17(7):e0262877. Epub 2022 Jul 21 doi: 10.1371/journal.pone.0262877. PMID: 35862385Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Recent systematic reviews

Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832

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