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Locally Advanced Urethral Urothelial Carcinoma

MedGen UID:
1702113
•Concept ID:
C5206697
•
Neoplastic Process

Definition

A urethral urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Urethral Urothelial Carcinoma

Professional guidelines

PubMed

European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update.
Gakis G, Bruins HM, Cathomas R, Compérat EM, Cowan NC, van der Heijden AG, Hernández V, Linares Espinós EE, Lorch A, Neuzillet Y, Ribal MJ, Rouanne M, Thalmann GN, Veskimäe E, Witjes AJ
Eur Urol Oncol 2020 Aug;3(4):424-432. Epub 2020 Jun 27 doi: 10.1016/j.euo.2020.06.003. PMID: 32605889
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Surgical management of bladder carcinoma.
Carrion R, Seigne J
Cancer Control 2002 Jul-Aug;9(4):284-92. doi: 10.1177/107327480200900403. PMID: 12228754

Recent clinical studies

Etiology

Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Primary urethral carcinoma: Results from a single center experience.
Calderón Cortez JF, Territo A, Fontana M, Gaya JM, Sanguedolce F, Palou J, Huguet J, Breda A
Actas Urol Esp (Engl Ed) 2022 Mar;46(2):70-77. Epub 2022 Feb 2 doi: 10.1016/j.acuroe.2020.10.017. PMID: 35120853
Secondary Urethral Malignancies Following Prostate Brachytherapy.
Agrawal S, Lacy JM, Bagga H, Angermeier KW, Ciezki J, Tendulkar RD, Reddy CA, Wood HM
Urology 2017 Dec;110:172-176. Epub 2017 Sep 4 doi: 10.1016/j.urology.2017.08.036. PMID: 28882777
Improving diagnostic molecular tests to monitor urothelial carcinoma recurrence.
Krabbe LM, Woldu SL, Shariat SF, Lotan Y
Expert Rev Mol Diagn 2016 Nov;16(11):1189-1199. Epub 2016 Oct 14 doi: 10.1080/14737159.2016.1244006. PMID: 27696932
Bladder cancer in Africa.
Heyns CF, van der Merwe A
Can J Urol 2008 Feb;15(1):3899-908. PMID: 18304401

Diagnosis

Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Primary urethral carcinoma: Results from a single center experience.
Calderón Cortez JF, Territo A, Fontana M, Gaya JM, Sanguedolce F, Palou J, Huguet J, Breda A
Actas Urol Esp (Engl Ed) 2022 Mar;46(2):70-77. Epub 2022 Feb 2 doi: 10.1016/j.acuroe.2020.10.017. PMID: 35120853
Secondary Urethral Malignancies Following Prostate Brachytherapy.
Agrawal S, Lacy JM, Bagga H, Angermeier KW, Ciezki J, Tendulkar RD, Reddy CA, Wood HM
Urology 2017 Dec;110:172-176. Epub 2017 Sep 4 doi: 10.1016/j.urology.2017.08.036. PMID: 28882777
Improving diagnostic molecular tests to monitor urothelial carcinoma recurrence.
Krabbe LM, Woldu SL, Shariat SF, Lotan Y
Expert Rev Mol Diagn 2016 Nov;16(11):1189-1199. Epub 2016 Oct 14 doi: 10.1080/14737159.2016.1244006. PMID: 27696932
Bladder cancer in Africa.
Heyns CF, van der Merwe A
Can J Urol 2008 Feb;15(1):3899-908. PMID: 18304401

Therapy

Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons.
Liao RS, Ruan HT, Jang A, Huynh M, Nadal Rios R, Hoffman-Censits JH, Wei S, Mian OY, Barata PC
Am Soc Clin Oncol Educ Book 2024 Jan;44:e430336. doi: 10.1200/EDBK_430336. PMID: 38176691
Evaluating Real-World Characteristics of Patients With Advanced Urothelial Carcinoma Eligible for Avelumab Maintenance Therapy: A Multicountry Retrospective Medical Chart Review.
Bellmunt J, Chang J, Pavilack-Kirker M, Cappelleri JC, Costa N, Esterberg E, Kearney M, Hitchens A, Candrilli SD, Ajmera M
Clin Genitourin Cancer 2023 Aug;21(4):459-466. Epub 2023 Mar 31 doi: 10.1016/j.clgc.2023.03.011. PMID: 37149458
Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
A Comprehensive Review of US FDA-Approved Immune Checkpoint Inhibitors in Urothelial Carcinoma.
Hsu FS, Su CH, Huang KH
J Immunol Res 2017;2017:6940546. Epub 2017 Dec 10 doi: 10.1155/2017/6940546. PMID: 29376081Free PMC Article
Surgical management of bladder carcinoma.
Carrion R, Seigne J
Cancer Control 2002 Jul-Aug;9(4):284-92. doi: 10.1177/107327480200900403. PMID: 12228754

Prognosis

Reprint of: Female Urethral Carcinoma: A contemporary review of the clinicopathologic features, with emphasis on the histo-anatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2023 Mar;133:126-135. Epub 2023 Mar 7 doi: 10.1016/j.humpath.2023.02.011. PMID: 36894368
Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Secondary Urethral Malignancies Following Prostate Brachytherapy.
Agrawal S, Lacy JM, Bagga H, Angermeier KW, Ciezki J, Tendulkar RD, Reddy CA, Wood HM
Urology 2017 Dec;110:172-176. Epub 2017 Sep 4 doi: 10.1016/j.urology.2017.08.036. PMID: 28882777
Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients.
Picozzi S, Ricci C, Gaeta M, Ratti D, Macchi A, Casellato S, Bozzini G, Carmignani L
J Urol 2012 Dec;188(6):2046-54. Epub 2012 Oct 18 doi: 10.1016/j.juro.2012.08.017. PMID: 23083867

Clinical prediction guides

Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Association Between Perioperative Chemotherapy and Survival in Men Undergoing Radical Resection for Primary Urethral Urothelial Carcinoma: An Analysis of the National Cancer Database.
Celtik K, Lim K, Dursun F, Xu J, Klaassen Z, Zhang J, Efstathiou E, Sonpavde G, Wallis C, Satkunasivam R
Clin Genitourin Cancer 2022 Jun;20(3):244-251. Epub 2022 Jan 31 doi: 10.1016/j.clgc.2022.01.011. PMID: 35181268
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Contemporary practice patterns and survival outcomes for locally advanced urethral malignancies: A National Cancer Database Analysis.
Cahn DB, Handorf E, Ristau BT, Geynisman DM, Simhan J, Kutikov A, Greenberg RE, Viterbo R, Chen DYT, Uzzo RG, Smaldone MC
Urol Oncol 2017 Dec;35(12):670.e15-670.e21. Epub 2017 Aug 10 doi: 10.1016/j.urolonc.2017.07.026. PMID: 28803701
The remnant urothelium after reconstructive bladder surgery.
Stenzl A, Bartsch G, Rogatsch H
Eur Urol 2002 Feb;41(2):124-31. doi: 10.1016/s0302-2838(01)00031-8. PMID: 12074398

Recent systematic reviews

Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949

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