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Renal Pelvis Urothelial Carcinoma, High Grade

MedGen UID:
1792938
•Concept ID:
C5556497
•
Neoplastic Process
Synonyms: High Grade Renal Pelvis Urothelial Carcinoma; High-Grade Renal Pelvis Urothelial Carcinoma; Renal Pelvis Urothelial Carcinoma, High-Grade

Definition

Renal pelvis urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal Pelvis Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Minimally invasive approach in the management of upper- urinary-tract tumours.
Adamis S, Varkarakis J
Scand J Urol Nephrol 2011 Dec;45(6):381-7. doi: 10.3109/00365599.2011.590999. PMID: 22070534

Recent clinical studies

Etiology

The prognostic impact of lymphovascular invasion for upper urinary tract urothelial carcinoma: A propensity score-weighted analysis.
Chang YL, Chen YT, Wang HH, Chiang PH, Cheng YT, Kang CH, Chuang YC, Lee WC, Yang WC, Liu HY, Su YL, Huang CC, Tse SM, Luo HL
Medicine (Baltimore) 2023 Apr 14;102(15):e33485. doi: 10.1097/MD.0000000000033485. PMID: 37058048Free PMC Article
Optimal management of recurrent and metastatic upper tract urothelial carcinoma: Implications of intensity modulated radiation therapy.
Kim MS, Koom WS, Cho JH, Kim SY, Lee IJ
Radiat Oncol 2022 Mar 9;17(1):51. doi: 10.1186/s13014-022-02020-7. PMID: 35264197Free PMC Article
Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma.
Kim TH, Lee CU, Kang M, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Sung HH
Sci Rep 2021 Apr 9;11(1):7828. doi: 10.1038/s41598-021-87573-5. PMID: 33837237Free PMC Article
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
Upper urothelial carcinoma in Balkan endemic nephropathy and non-endemic regions: a comparative study of pathological features.
Jankovic Velickovic L, Hattori T, Dolicanin Z, Visnjic M, Krstic M, Ilic I, Cukuranovic R, Rajic M, Stefanovic V
Pathol Res Pract 2009;205(2):89-96. Epub 2008 Dec 21 doi: 10.1016/j.prp.2008.09.002. PMID: 19106018

Diagnosis

Optimal management of recurrent and metastatic upper tract urothelial carcinoma: Implications of intensity modulated radiation therapy.
Kim MS, Koom WS, Cho JH, Kim SY, Lee IJ
Radiat Oncol 2022 Mar 9;17(1):51. doi: 10.1186/s13014-022-02020-7. PMID: 35264197Free PMC Article
Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914

Therapy

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma.
Mandalapu RS, Remzi M, de Reijke TM, Margulis V, Palou J, Kapoor A, Yossepowitch O, Coleman J, Traxer O, Anderson JK, Catto J, de la Rosette J, O'Brien T, Zlotta A, Matin SF
World J Urol 2017 Mar;35(3):355-365. Epub 2016 May 27 doi: 10.1007/s00345-016-1859-6. PMID: 27233780Free PMC Article
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218

Prognosis

Optimal management of recurrent and metastatic upper tract urothelial carcinoma: Implications of intensity modulated radiation therapy.
Kim MS, Koom WS, Cho JH, Kim SY, Lee IJ
Radiat Oncol 2022 Mar 9;17(1):51. doi: 10.1186/s13014-022-02020-7. PMID: 35264197Free PMC Article
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma.
Kim TH, Lee CU, Kang M, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Sung HH
Sci Rep 2021 Apr 9;11(1):7828. doi: 10.1038/s41598-021-87573-5. PMID: 33837237Free PMC Article
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914
The prognostic value of p53, Ki-67 and matrix metalloproteinases MMP-2 and MMP-9 in transitional cell carcinoma of the renal pelvis and ureter.
Kamijima S, Tobe T, Suyama T, Ueda T, Igarashi T, Ichikawa T, Ito H
Int J Urol 2005 Nov;12(11):941-7. doi: 10.1111/j.1442-2042.2005.01159.x. PMID: 16351648

Clinical prediction guides

The prognostic impact of lymphovascular invasion for upper urinary tract urothelial carcinoma: A propensity score-weighted analysis.
Chang YL, Chen YT, Wang HH, Chiang PH, Cheng YT, Kang CH, Chuang YC, Lee WC, Yang WC, Liu HY, Su YL, Huang CC, Tse SM, Luo HL
Medicine (Baltimore) 2023 Apr 14;102(15):e33485. doi: 10.1097/MD.0000000000033485. PMID: 37058048Free PMC Article
Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma.
Kim TH, Lee CU, Kang M, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Sung HH
Sci Rep 2021 Apr 9;11(1):7828. doi: 10.1038/s41598-021-87573-5. PMID: 33837237Free PMC Article
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel.
Seisen T, Peyronnet B, Dominguez-Escrig JL, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Cowan NC, Kaasinen E, Palou J, van Rhijn BW, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol 2016 Dec;70(6):1052-1068. Epub 2016 Jul 28 doi: 10.1016/j.eururo.2016.07.014. PMID: 27477528
Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience.
Fajkovic H, Klatte T, Nagele U, Dunzinger M, Zigeuner R, Hübner W, Remzi M
World J Urol 2013 Feb;31(1):37-44. Epub 2012 Sep 27 doi: 10.1007/s00345-012-0948-4. PMID: 23014836

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