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Metastatic Urothelial Carcinoma

MedGen UID:
926286
Concept ID:
C4288754
Neoplastic Process
Synonyms: Metastatic Transitional Cell Carcinoma of the Urinary Tract; Metastatic transitional cell carcinoma of urinary tract; Metastatic urothelial carcinoma
SNOMED CT: Metastatic transitional cell carcinoma of urinary tract (458321000124102); Metastatic urothelial carcinoma (458321000124102)

Definition

A carcinoma that arises from the urothelium and has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Fenor de la Maza MD, Villacampa G, Miñana B, Barbas Bernardos G, Andrés G, González-Padilla DA, Ramón de Fata F, Sanz J, Cambeiro M, Aristu J, Gúrpide A, Villacampa F, Gracia JLP
Clin Genitourin Cancer 2024 Apr;22(2):330-335. Epub 2023 Dec 13 doi: 10.1016/j.clgc.2023.12.001. PMID: 38172023
Gurney H, Clay TD, Oliveira N, Wong S, Tran B, Harris C
Asia Pac J Clin Oncol 2023 Dec;19(6):585-595. Epub 2023 Sep 20 doi: 10.1111/ajco.14001. PMID: 37727139
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Recent clinical studies

Etiology

Powles T, Valderrama BP, Gupta S, Bedke J, Kikuchi E, Hoffman-Censits J, Iyer G, Vulsteke C, Park SH, Shin SJ, Castellano D, Fornarini G, Li JR, Gümüş M, Mar N, Loriot Y, Fléchon A, Duran I, Drakaki A, Narayanan S, Yu X, Gorla S, Homet Moreno B, van der Heijden MS; EV-302 Trial Investigators
N Engl J Med 2024 Mar 7;390(10):875-888. doi: 10.1056/NEJMoa2312117. PMID: 38446675
van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators
N Engl J Med 2023 Nov 9;389(19):1778-1789. Epub 2023 Oct 22 doi: 10.1056/NEJMoa2309863. PMID: 37870949
Loriot Y, Matsubara N, Park SH, Huddart RA, Burgess EF, Houede N, Banek S, Guadalupi V, Ku JH, Valderrama BP, Tran B, Triantos S, Kean Y, Akapame S, Deprince K, Mukhopadhyay S, Stone NL, Siefker-Radtke AO; THOR Cohort 1 Investigators
N Engl J Med 2023 Nov 23;389(21):1961-1971. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2308849. PMID: 37870920
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632

Diagnosis

Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Knowles M, Dyrskjøt L, Heath EI, Bellmunt J, Siefker-Radtke AO
Cancer Cell 2021 May 10;39(5):583-585. doi: 10.1016/j.ccell.2021.04.012. PMID: 33974855
Sheng X, Yan X, Wang L, Shi Y, Yao X, Luo H, Shi B, Liu J, He Z, Yu G, Ying J, Han W, Hu C, Ling Y, Chi Z, Cui C, Si L, Fang J, Zhou A, Guo J
Clin Cancer Res 2021 Jan 1;27(1):43-51. Epub 2020 Oct 27 doi: 10.1158/1078-0432.CCR-20-2488. PMID: 33109737
Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE 3rd, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S
Nat Med 2020 May;26(5):693-698. Epub 2020 May 11 doi: 10.1038/s41591-020-0860-1. PMID: 32405063Free PMC Article
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094

Therapy

Powles T, Valderrama BP, Gupta S, Bedke J, Kikuchi E, Hoffman-Censits J, Iyer G, Vulsteke C, Park SH, Shin SJ, Castellano D, Fornarini G, Li JR, Gümüş M, Mar N, Loriot Y, Fléchon A, Duran I, Drakaki A, Narayanan S, Yu X, Gorla S, Homet Moreno B, van der Heijden MS; EV-302 Trial Investigators
N Engl J Med 2024 Mar 7;390(10):875-888. doi: 10.1056/NEJMoa2312117. PMID: 38446675
van der Heijden MS, Sonpavde G, Powles T, Necchi A, Burotto M, Schenker M, Sade JP, Bamias A, Beuzeboc P, Bedke J, Oldenburg J, Chatta G, Ürün Y, Ye D, He Z, Valderrama BP, Ku JH, Tomita Y, Filian J, Wang L, Purcea D, Patel MY, Nasroulah F, Galsky MD; CheckMate 901 Trial Investigators
N Engl J Med 2023 Nov 9;389(19):1778-1789. Epub 2023 Oct 22 doi: 10.1056/NEJMoa2309863. PMID: 37870949
Loriot Y, Matsubara N, Park SH, Huddart RA, Burgess EF, Houede N, Banek S, Guadalupi V, Ku JH, Valderrama BP, Tran B, Triantos S, Kean Y, Akapame S, Deprince K, Mukhopadhyay S, Stone NL, Siefker-Radtke AO; THOR Cohort 1 Investigators
N Engl J Med 2023 Nov 23;389(21):1961-1971. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2308849. PMID: 37870920
Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729Free PMC Article
Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulović S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte R, Wang J, Huang B, Davis C, Fowst C, Costa N, Blake-Haskins JA, di Pietro A, Grivas P
N Engl J Med 2020 Sep 24;383(13):1218-1230. Epub 2020 Sep 18 doi: 10.1056/NEJMoa2002788. PMID: 32945632

Prognosis

Balar AV, Castellano DE, Grivas P, Vaughn DJ, Powles T, Vuky J, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Necchi A, Petrylak DP, Plimack ER, Xu JZ, Imai K, Moreno BH, Bellmunt J, de Wit R, O'Donnell PH
Ann Oncol 2023 Mar;34(3):289-299. Epub 2022 Dec 6 doi: 10.1016/j.annonc.2022.11.012. PMID: 36494006
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713
Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE 3rd, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S
Nat Med 2020 May;26(5):693-698. Epub 2020 May 11 doi: 10.1038/s41591-020-0860-1. PMID: 32405063Free PMC Article
Rosenberg J, Sridhar SS, Zhang J, Smith D, Ruether D, Flaig TW, Baranda J, Lang J, Plimack ER, Sangha R, Heath EI, Merchan J, Quinn DI, Srinivas S, Milowsky M, Wu C, Gartner EM, Zuo P, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2020 Apr 1;38(10):1041-1049. Epub 2020 Feb 7 doi: 10.1200/JCO.19.02044. PMID: 32031899Free PMC Article
Loriot Y, Necchi A, Park SH, Garcia-Donas J, Huddart R, Burgess E, Fleming M, Rezazadeh A, Mellado B, Varlamov S, Joshi M, Duran I, Tagawa ST, Zakharia Y, Zhong B, Stuyckens K, Santiago-Walker A, De Porre P, O'Hagan A, Avadhani A, Siefker-Radtke AO; BLC2001 Study Group
N Engl J Med 2019 Jul 25;381(4):338-348. doi: 10.1056/NEJMoa1817323. PMID: 31340094

Clinical prediction guides

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Powles T, Csőszi T, Özgüroğlu M, Matsubara N, Géczi L, Cheng SY, Fradet Y, Oudard S, Vulsteke C, Morales Barrera R, Fléchon A, Gunduz S, Loriot Y, Rodriguez-Vida A, Mamtani R, Yu EY, Nam K, Imai K, Homet Moreno B, Alva A; KEYNOTE-361 Investigators
Lancet Oncol 2021 Jul;22(7):931-945. Epub 2021 May 26 doi: 10.1016/S1470-2045(21)00152-2. PMID: 34051178
Galsky MD, Arija JÁA, Bamias A, Davis ID, De Santis M, Kikuchi E, Garcia-Del-Muro X, De Giorgi U, Mencinger M, Izumi K, Panni S, Gumus M, Özgüroğlu M, Kalebasty AR, Park SH, Alekseev B, Schutz FA, Li JR, Ye D, Vogelzang NJ, Bernhard S, Tayama D, Mariathasan S, Mecke A, Thåström A, Grande E; IMvigor130 Study Group
Lancet 2020 May 16;395(10236):1547-1557. doi: 10.1016/S0140-6736(20)30230-0. PMID: 32416780
Rosenberg J, Sridhar SS, Zhang J, Smith D, Ruether D, Flaig TW, Baranda J, Lang J, Plimack ER, Sangha R, Heath EI, Merchan J, Quinn DI, Srinivas S, Milowsky M, Wu C, Gartner EM, Zuo P, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2020 Apr 1;38(10):1041-1049. Epub 2020 Feb 7 doi: 10.1200/JCO.19.02044. PMID: 32031899Free PMC Article
Rosenberg JE, O'Donnell PH, Balar AV, McGregor BA, Heath EI, Yu EY, Galsky MD, Hahn NM, Gartner EM, Pinelli JM, Liang SY, Melhem-Bertrandt A, Petrylak DP
J Clin Oncol 2019 Oct 10;37(29):2592-2600. Epub 2019 Jul 29 doi: 10.1200/JCO.19.01140. PMID: 31356140Free PMC Article

Recent systematic reviews

Hinojosa-Gonzalez DE, Saffati G, Salgado-Garza G, Patel S, Kronstedt S, Jones JA, Taylor JM, Yen AE, Slawin JR
Urol Oncol 2024 Nov;42(11):361-369. Epub 2024 Aug 6 doi: 10.1016/j.urolonc.2024.07.006. PMID: 39112104
Kardoust Parizi M, Matsukawa A, Bekku K, Klemm J, Alimohammadi A, Laukhtina E, Karakiewicz P, Chiujdea S, Abufaraj M, Krauter J, Shariat SF
Eur Urol Oncol 2024 Aug;7(4):663-676. Epub 2023 Nov 18 doi: 10.1016/j.euo.2023.11.001. PMID: 37980251
Liao PF, Wang PY, Peng TR
Curr Oncol 2023 Nov 17;30(11):9940-9952. doi: 10.3390/curroncol30110722. PMID: 37999142Free PMC Article
Maisch P, Hwang EC, Kim K, Narayan VM, Bakker C, Kunath F, Dahm P
Cochrane Database Syst Rev 2023 Oct 9;10(10):CD013774. doi: 10.1002/14651858.CD013774.pub2. PMID: 37811690Free PMC Article
Chierigo F, Wenzel M, Würnschimmel C, Flammia RS, Horlemann B, Tian Z, Saad F, Chun FKH, Tilki D, Shariat SF, Gallucci M, Borghesi M, Suardi N, Terrone C, Karakiewicz PI
Crit Rev Oncol Hematol 2022 Jan;169:103534. Epub 2021 Nov 22 doi: 10.1016/j.critrevonc.2021.103534. PMID: 34823022

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