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Prostatic urethra urothelial carcinoma

MedGen UID:
271406
•Concept ID:
C1514522
•
Neoplastic Process
Synonyms: Prostatic Urethra Urothelial Carcinoma; prostatic urethra urothelial carcinoma
 
Monarch Initiative: MONDO:0003790

Definition

An urothelial carcinoma that arises from the urothelial lining of the prostatic urethra. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstatic urethra urothelial carcinoma

Professional guidelines

PubMed

Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

Recent clinical studies

Etiology

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial.
Boorjian SA, Alemozaffar M, Konety BR, Shore ND, Gomella LG, Kamat AM, Bivalacqua TJ, Montgomery JS, Lerner SP, Busby JE, Poch M, Crispen PL, Steinberg GD, Schuckman AK, Downs TM, Svatek RS, Mashni J Jr, Lane BR, Guzzo TJ, Bratslavsky G, Karsh LI, Woods ME, Brown G, Canter D, Luchey A, Lotan Y, Krupski T, Inman BA, Williams MB, Cookson MS, Keegan KA, Andriole GL Jr, Sankin AI, Boyd A, O'Donnell MA, Sawutz D, Philipson R, Coll R, Narayan VM, Treasure FP, Yla-Herttuala S, Parker NR, Dinney CPN
Lancet Oncol 2021 Jan;22(1):107-117. Epub 2020 Nov 27 doi: 10.1016/S1470-2045(20)30540-4. PMID: 33253641Free PMC Article
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Urothelial carcinoma in the prostatic urethra and prostate: current controversies.
Liedberg F, Chebil G, Månsson W
Expert Rev Anticancer Ther 2007 Mar;7(3):383-90. doi: 10.1586/14737140.7.3.383. PMID: 17338657
Indications for urethrectomy.
Elmajian DA
Semin Urol Oncol 2001 Feb;19(1):37-44. PMID: 11246732

Diagnosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.
Flaig TW, Spiess PE, Abern M, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chan K, Chang S, Friedlander T, Greenberg RE, Guru KA, Herr HW, Hoffman-Censits J, Kishan A, Kundu S, Lele SM, Mamtani R, Margulis V, Mian OY, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Parikh M, Patterson A, Plimack ER, Pohar KS, Preston MA, Richards K, Sexton WJ, Siefker-Radtke AO, Tollefson M, Tward J, Wright JL, Dwyer MA, Cassara CJ, Gurski LA
J Natl Compr Canc Netw 2022 Aug;20(8):866-878. doi: 10.6004/jnccn.2022.0041. PMID: 35948037
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Urothelial carcinoma in the prostatic urethra and prostate: current controversies.
Liedberg F, Chebil G, Månsson W
Expert Rev Anticancer Ther 2007 Mar;7(3):383-90. doi: 10.1586/14737140.7.3.383. PMID: 17338657

Therapy

Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial.
Boorjian SA, Alemozaffar M, Konety BR, Shore ND, Gomella LG, Kamat AM, Bivalacqua TJ, Montgomery JS, Lerner SP, Busby JE, Poch M, Crispen PL, Steinberg GD, Schuckman AK, Downs TM, Svatek RS, Mashni J Jr, Lane BR, Guzzo TJ, Bratslavsky G, Karsh LI, Woods ME, Brown G, Canter D, Luchey A, Lotan Y, Krupski T, Inman BA, Williams MB, Cookson MS, Keegan KA, Andriole GL Jr, Sankin AI, Boyd A, O'Donnell MA, Sawutz D, Philipson R, Coll R, Narayan VM, Treasure FP, Yla-Herttuala S, Parker NR, Dinney CPN
Lancet Oncol 2021 Jan;22(1):107-117. Epub 2020 Nov 27 doi: 10.1016/S1470-2045(20)30540-4. PMID: 33253641Free PMC Article
ICUD-SIU International Consultation on Bladder Cancer 2017: management of non-muscle invasive bladder cancer.
Monteiro LL, Witjes JA, Agarwal PK, Anderson CB, Bivalacqua TJ, Bochner BH, Boormans JL, Chang SS, Domínguez-Escrig JL, McKiernan JM, Dinney C, Godoy G, Kulkarni GS, Mariappan P, O'Donnell MA, Rentsch CA, Shah JB, Solsona E, Svatek RS, van der Heijden AG, van Valenberg FJP, Kassouf W
World J Urol 2019 Jan;37(1):51-60. Epub 2018 Aug 14 doi: 10.1007/s00345-018-2438-9. PMID: 30109483
Photodynamic therapy in urology: what can we do now and where are we heading?
Bozzini G, Colin P, Betrouni N, Nevoux P, Ouzzane A, Puech P, Villers A, Mordon S
Photodiagnosis Photodyn Ther 2012 Sep;9(3):261-73. Epub 2012 Feb 22 doi: 10.1016/j.pdpdt.2012.01.005. PMID: 22959806
Urothelial carcinoma in the prostatic urethra and prostate: current controversies.
Liedberg F, Chebil G, Månsson W
Expert Rev Anticancer Ther 2007 Mar;7(3):383-90. doi: 10.1586/14737140.7.3.383. PMID: 17338657
Superficial urothelial cancer in the prostatic urethra.
Kirkali Z, Canda AE
ScientificWorldJournal 2006 Feb 28;6:2603-10. doi: 10.1100/tsw.2006.402. PMID: 17619737Free PMC Article

Prognosis

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Prognostic Genetic Signatures in Upper Tract Urothelial Carcinoma.
Li Q, Bagrodia A, Cha EK, Coleman JA
Curr Urol Rep 2016 Feb;17(2):12. doi: 10.1007/s11934-015-0566-y. PMID: 26757906Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Urothelial carcinoma in the prostatic urethra and prostate: current controversies.
Liedberg F, Chebil G, Månsson W
Expert Rev Anticancer Ther 2007 Mar;7(3):383-90. doi: 10.1586/14737140.7.3.383. PMID: 17338657

Clinical prediction guides

European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines.
Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Aberrant GATA3 Staining in Prostatic Adenocarcinoma: A Potential Diagnostic Pitfall.
McDonald TM, Epstein JI
Am J Surg Pathol 2021 Mar 1;45(3):341-346. doi: 10.1097/PAS.0000000000001557. PMID: 32769430
Prognostic Genetic Signatures in Upper Tract Urothelial Carcinoma.
Li Q, Bagrodia A, Cha EK, Coleman JA
Curr Urol Rep 2016 Feb;17(2):12. doi: 10.1007/s11934-015-0566-y. PMID: 26757906Free PMC Article
The occult urothelial cancer.
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall.
Gordetsky J, Epstein JI
Am J Surg Pathol 2014 Jul;38(7):941-5. doi: 10.1097/PAS.0000000000000178. PMID: 24503758

Recent systematic reviews

Follow-up of the Urethra and Management of Urethral Recurrence After Radical Cystectomy: A Systematic Review and Proposal of Management Algorithm by the European Association of Urology-Young Academic Urologists: Urothelial Carcinoma Working Group.
Laukhtina E, Moschini M, Soria F, Andrea DD, Teoh JY, Mori K, Albisinni S, Mari A, Krajewski W, Cimadamore A, Abufaraj M, Enikeev D, Neuzillet Y, Giannarini G, Xylinas E, Kamat AM, Roupret M, Babjuk M, Witjes JA, Shariat SF, Pradere B; European Association of Urology; Young Academic Urologists EAU-YAU: Urothelial Carcinoma Working Group; European Association of Urology Section of Oncological Urology ESOU
Eur Urol Focus 2022 Nov;8(6):1635-1642. Epub 2022 Mar 23 doi: 10.1016/j.euf.2022.03.004. PMID: 35337773
Ureteral and urethral recurrence after radical cystectomy: a systematic review.
Carando R, Shariat SF, Moschini M, D'Andrea D
Curr Opin Urol 2020 May;30(3):441-448. doi: 10.1097/MOU.0000000000000752. PMID: 32235282
Current Disease Management of Primary Urethral Carcinoma.
Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF
Eur Urol Focus 2019 Sep;5(5):722-734. Epub 2019 Jul 13 doi: 10.1016/j.euf.2019.07.001. PMID: 31307949
Urethral recurrence after radical cystectomy for urothelial carcinoma: A systematic review and meta-analysis.
Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Kübler H, Stenzl A, Gakis G
Urol Oncol 2018 Feb;36(2):54-59. Epub 2017 Nov 28 doi: 10.1016/j.urolonc.2017.11.007. PMID: 29196179
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

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    Reviews

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