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Renal pelvis urothelial carcinoma

MedGen UID:
1648131
•Concept ID:
C4087468
•
Neoplastic Process
Synonyms: kidney renal pelvis urothelial cancer; Renal Pelvis Transitional Cell Carcinoma; renal pelvis transitional cell carcinoma; renal pelvis urothelial cancer; Renal Pelvis Urothelial Carcinoma; renal pelvis urothelial carcinoma; Transitional Cell Carcinoma of Renal Pelvis; transitional cell carcinoma of renal pelvis; Transitional Cell Carcinoma of the Renal Pelvis; transitional cell carcinoma of the renal pelvis; Urothelial Cell Carcinoma of Renal Pelvis; urothelial cell carcinoma of renal pelvis; Urothelial Cell Carcinoma of the Renal Pelvis; urothelial cell carcinoma of the renal pelvis
 
Monarch Initiative: MONDO:0005221

Definition

A carcinoma that arises from the urothelial lining of the renal pelvis. It is associated with tobacco use and usually presents with gross or microscopic hematuria. Urothelial carcinomas of the renal pelvis are usually of higher grade and higher stage compared to bladder urothelial carcinomas. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline.
Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Optimizing management of upper tract urothelial carcinoma.
Campbell MT, Shah AY, Matin SF, Siefker-Radtke AO
Urol Oncol 2017 Jul;35(7):492-498. Epub 2017 Jun 1 doi: 10.1016/j.urolonc.2017.05.009. PMID: 28579283

Recent clinical studies

Etiology

Cardiac and Intramuscular Metastases Following Nephroureterectomy for Metachronous Urothelial Carcinoma.
Chan HY, Chan WY, Wong Su Lin J
Am J Case Rep 2024 Apr 23;25:e942864. doi: 10.12659/AJCR.942864. PMID: 38650318Free PMC Article
Impact of the primary tumor location on secondary sites and overall mortality in patients with metastatic upper tract urothelial carcinoma.
Collà Ruvolo C, Deuker M, Wenzel M, Nocera L, Würnschimmel C, Califano G, Tian Z, Saad F, Briganti A, Xylinas E, Verze P, Musi G, Shariat SF, Mirone V, Karakiewicz PI
Urol Oncol 2022 Sep;40(9):411.e1-411.e8. Epub 2022 Jul 25 doi: 10.1016/j.urolonc.2022.06.009. PMID: 35902301
Tumor Size Predicts Muscle-invasive and Non-organ-confined Disease in Upper Tract Urothelial Carcinoma at Radical Nephroureterectomy.
Collà Ruvolo C, Nocera L, Stolzenbach LF, Wenzel M, Califano G, Tian Z, Verze P, Shariat SF, Saad F, Briganti A, Mirone V, Karakiewicz PI
Eur Urol Focus 2022 Mar;8(2):498-505. Epub 2021 Mar 15 doi: 10.1016/j.euf.2021.03.003. PMID: 33737024
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
Lwin AA, Hsu CH, Chipollini J
Clin Genitourin Cancer 2020 Feb;18(1):45-49.e1. Epub 2019 Nov 6 doi: 10.1016/j.clgc.2019.10.023. PMID: 31786118

Diagnosis

Cardiac and Intramuscular Metastases Following Nephroureterectomy for Metachronous Urothelial Carcinoma.
Chan HY, Chan WY, Wong Su Lin J
Am J Case Rep 2024 Apr 23;25:e942864. doi: 10.12659/AJCR.942864. PMID: 38650318Free PMC Article
High serum levels of CA 19-9 and CYFRA21-1 caused by renal pelvis urothelial carcinoma: a report of two cases.
Yin G, Zhang M, Zhao B, Yang Z
J Int Med Res 2021 Mar;49(3):3000605211002692. doi: 10.1177/03000605211002692. PMID: 33752511Free PMC Article
HDAC11: a rising star in epigenetics.
Liu SS, Wu F, Jin YM, Chang WQ, Xu TM
Biomed Pharmacother 2020 Nov;131:110607. Epub 2020 Aug 22 doi: 10.1016/j.biopha.2020.110607. PMID: 32841898
Renal pelvis urothelial carcinoma of the upper moiety in complete right renal duplex: a case report.
Zhang Y, Yu Q, Zhang Z, Liu R, Xu Y
Int J Clin Exp Pathol 2015;8(11):15422-5. Epub 2015 Nov 1 PMID: 26823906Free PMC Article
Collecting duct carcinoma: an entity to be redefined?
Kafé H, Verbavatz JM, Cochand-Priollet B, Castagnet P, Vieillefond A
Virchows Arch 2004 Dec;445(6):637-40. Epub 2004 Oct 8 doi: 10.1007/s00428-004-1124-z. PMID: 15480763

Therapy

HDAC11: a rising star in epigenetics.
Liu SS, Wu F, Jin YM, Chang WQ, Xu TM
Biomed Pharmacother 2020 Nov;131:110607. Epub 2020 Aug 22 doi: 10.1016/j.biopha.2020.110607. PMID: 32841898
Perioperative Immunotherapy in Muscle-Invasive Bladder Cancer and Upper Tract Urothelial Carcinoma.
Teo MY, Rosenberg JE
Urol Clin North Am 2018 May;45(2):287-295. doi: 10.1016/j.ucl.2017.12.011. PMID: 29650143

Prognosis

Cardiac and Intramuscular Metastases Following Nephroureterectomy for Metachronous Urothelial Carcinoma.
Chan HY, Chan WY, Wong Su Lin J
Am J Case Rep 2024 Apr 23;25:e942864. doi: 10.12659/AJCR.942864. PMID: 38650318Free PMC Article
Impact of the primary tumor location on secondary sites and overall mortality in patients with metastatic upper tract urothelial carcinoma.
Collà Ruvolo C, Deuker M, Wenzel M, Nocera L, Würnschimmel C, Califano G, Tian Z, Saad F, Briganti A, Xylinas E, Verze P, Musi G, Shariat SF, Mirone V, Karakiewicz PI
Urol Oncol 2022 Sep;40(9):411.e1-411.e8. Epub 2022 Jul 25 doi: 10.1016/j.urolonc.2022.06.009. PMID: 35902301
Tumor Size Predicts Muscle-invasive and Non-organ-confined Disease in Upper Tract Urothelial Carcinoma at Radical Nephroureterectomy.
Collà Ruvolo C, Nocera L, Stolzenbach LF, Wenzel M, Califano G, Tian Z, Verze P, Shariat SF, Saad F, Briganti A, Mirone V, Karakiewicz PI
Eur Urol Focus 2022 Mar;8(2):498-505. Epub 2021 Mar 15 doi: 10.1016/j.euf.2021.03.003. PMID: 33737024
Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
Lwin AA, Hsu CH, Chipollini J
Clin Genitourin Cancer 2020 Feb;18(1):45-49.e1. Epub 2019 Nov 6 doi: 10.1016/j.clgc.2019.10.023. PMID: 31786118
Renal pelvis urothelial carcinoma of the upper moiety in complete right renal duplex: a case report.
Zhang Y, Yu Q, Zhang Z, Liu R, Xu Y
Int J Clin Exp Pathol 2015;8(11):15422-5. Epub 2015 Nov 1 PMID: 26823906Free PMC Article

Clinical prediction guides

Impact of the primary tumor location on secondary sites and overall mortality in patients with metastatic upper tract urothelial carcinoma.
Collà Ruvolo C, Deuker M, Wenzel M, Nocera L, Würnschimmel C, Califano G, Tian Z, Saad F, Briganti A, Xylinas E, Verze P, Musi G, Shariat SF, Mirone V, Karakiewicz PI
Urol Oncol 2022 Sep;40(9):411.e1-411.e8. Epub 2022 Jul 25 doi: 10.1016/j.urolonc.2022.06.009. PMID: 35902301
Tumor Size Predicts Muscle-invasive and Non-organ-confined Disease in Upper Tract Urothelial Carcinoma at Radical Nephroureterectomy.
Collà Ruvolo C, Nocera L, Stolzenbach LF, Wenzel M, Califano G, Tian Z, Verze P, Shariat SF, Saad F, Briganti A, Mirone V, Karakiewicz PI
Eur Urol Focus 2022 Mar;8(2):498-505. Epub 2021 Mar 15 doi: 10.1016/j.euf.2021.03.003. PMID: 33737024
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?
Lwin AA, Hsu CH, Chipollini J
Clin Genitourin Cancer 2020 Feb;18(1):45-49.e1. Epub 2019 Nov 6 doi: 10.1016/j.clgc.2019.10.023. PMID: 31786118
Renal pelvis urothelial carcinoma of the upper moiety in complete right renal duplex: a case report.
Zhang Y, Yu Q, Zhang Z, Liu R, Xu Y
Int J Clin Exp Pathol 2015;8(11):15422-5. Epub 2015 Nov 1 PMID: 26823906Free PMC Article

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