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Biliary Tract Carcinoma

MedGen UID:
1648585
•Concept ID:
C4745063
•
Neoplastic Process

Definition

A carcinoma arising from the intrahepatic bile ducts, hepatic ducts, common bile duct, cystic duct, or gallbladder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBiliary Tract Carcinoma

Professional guidelines

PubMed

Mutational spectrum for guiding the decision of adjuvant treatment in patients with resected biliary tract carcinoma.
Li Y, Tan C, Yin X, Zhu S, Cai R, Liao C, Wu Y, Zeng Q, Cai C, Xie W, He X, Wen HQ, Lin G, He Q, He T, Gu P, Liu CJ
Cancer Med 2023 Aug;12(15):16076-16086. Epub 2023 Jun 21 doi: 10.1002/cam4.6261. PMID: 37341068Free PMC Article
Treatment of biliary tract carcinoma over the last 30 years.
Midorikawa Y
Biosci Trends 2022 Jul 20;16(3):189-197. Epub 2022 Jun 23 doi: 10.5582/bst.2022.01267. PMID: 35732436
Systemic treatment options for advanced biliary tract carcinoma.
Xie C, McGrath NA, Monge Bonilla C, Fu J
J Gastroenterol 2020 Oct;55(10):944-957. Epub 2020 Aug 3 doi: 10.1007/s00535-020-01712-9. PMID: 32748173Free PMC Article

Recent clinical studies

Etiology

Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool.
Ma Y, Pan Y, Li Y, Guan H, Dai G
J Cancer Res Clin Oncol 2024 May 9;150(5):247. doi: 10.1007/s00432-024-05771-w. PMID: 38722378Free PMC Article
Past, present, and future of FGFR inhibitors in cholangiocarcinoma: from biological mechanisms to clinical applications.
Amadeo E, Rossari F, Vitiello F, Burgio V, Persano M, Cascinu S, Casadei-Gardini A, Rimini M
Expert Rev Clin Pharmacol 2023 Jul-Dec;16(7):631-642. Epub 2023 Jul 3 doi: 10.1080/17512433.2023.2232302. PMID: 37387533
Management of occluded metallic stents in malignant hilar biliary stricture.
Fujii M, Kawamoto H, Tsutsumi K, Kato H, Hirao K, Kurihara N, Mizuno O, Ishida E, Ogawa T, Fukatsu H, Yamamoto K
Hepatogastroenterology 2013 May;60(123):447-51. doi: 10.5754/hge12679. PMID: 23108079
Parapapillary choledochoduodenal fistula associated with cholangiocarcinoma.
Kuroki T, Fukuda K, Tajima Y, Matsuzaki S, Kitajima T, Furui J, Kanematsu T
J Hepatobiliary Pancreat Surg 2005;12(2):143-6. doi: 10.1007/s00534-004-0943-2. PMID: 15868079
Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection.
Ishikawa M, Miyauchi T, Yagi K, Chikaishi H, Fukuta Y, Miyake H, Harada M, Yogita S, Tashiro S
World J Surg 1999 Jan;23(1):75-9. doi: 10.1007/s002689900568. PMID: 9841767

Diagnosis

Advances in stent therapy for malignant biliary obstruction.
He X, Zhu Y, Wang Y, Hao Y, Hong J
Abdom Radiol (NY) 2021 Jan;46(1):351-361. doi: 10.1007/s00261-020-02593-5. PMID: 32451676
Molecular genetics and targeted therapeutics in biliary tract carcinoma.
Marks EI, Yee NS
World J Gastroenterol 2016 Jan 28;22(4):1335-47. doi: 10.3748/wjg.v22.i4.1335. PMID: 26819503Free PMC Article
Management of occluded metallic stents in malignant hilar biliary stricture.
Fujii M, Kawamoto H, Tsutsumi K, Kato H, Hirao K, Kurihara N, Mizuno O, Ishida E, Ogawa T, Fukatsu H, Yamamoto K
Hepatogastroenterology 2013 May;60(123):447-51. doi: 10.5754/hge12679. PMID: 23108079
Diagnosis of anomalous pancreaticobiliary junction: value of magnetic resonance cholangiopancreatography.
Sugiyama M, Baba M, Atomi Y, Hanaoka H, Mizutani Y, Hachiya J
Surgery 1998 Apr;123(4):391-7. PMID: 9551064
Porcelain gallbladder in a child: a case report and review.
Casteel HB, Williamson SL, Golladay ES, Fiedorek SC
J Pediatr Surg 1990 Dec;25(12):1302-3. doi: 10.1016/0022-3468(90)90540-p. PMID: 2286916

Therapy

Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool.
Ma Y, Pan Y, Li Y, Guan H, Dai G
J Cancer Res Clin Oncol 2024 May 9;150(5):247. doi: 10.1007/s00432-024-05771-w. PMID: 38722378Free PMC Article
Past, present, and future of FGFR inhibitors in cholangiocarcinoma: from biological mechanisms to clinical applications.
Amadeo E, Rossari F, Vitiello F, Burgio V, Persano M, Cascinu S, Casadei-Gardini A, Rimini M
Expert Rev Clin Pharmacol 2023 Jul-Dec;16(7):631-642. Epub 2023 Jul 3 doi: 10.1080/17512433.2023.2232302. PMID: 37387533
Surufatinib: First Approval.
Syed YY
Drugs 2021 Apr;81(6):727-732. doi: 10.1007/s40265-021-01489-y. PMID: 33788183
PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay.
Sakamoto Y, Yamagishi S, Tanizawa Y, Tajimi M, Okusaka T, Ojima H
Jpn J Clin Oncol 2018 Apr 1;48(4):396-399. doi: 10.1093/jjco/hyy011. PMID: 29474549
Management of occluded metallic stents in malignant hilar biliary stricture.
Fujii M, Kawamoto H, Tsutsumi K, Kato H, Hirao K, Kurihara N, Mizuno O, Ishida E, Ogawa T, Fukatsu H, Yamamoto K
Hepatogastroenterology 2013 May;60(123):447-51. doi: 10.5754/hge12679. PMID: 23108079

Prognosis

Prognostic significance of tumor budding in biliary tract cancer.
Regmi P, Paudyal A, Paudyal P, Hu HJ, Liu F, Ma WJ, Jin YW, Li FY
Eur J Surg Oncol 2022 Jan;48(1):160-168. Epub 2021 Aug 13 doi: 10.1016/j.ejso.2021.08.008. PMID: 34412954
Mutational spectrum and precision oncology for biliary tract carcinoma.
Lin J, Cao Y, Yang X, Li G, Shi Y, Wang D, Long J, Song Y, Mao J, Xie F, Bai Y, Zhang L, Yang X, Wan X, Wang A, Guan M, Zhao L, Hu K, Pan J, Huo L, Lu X, Mao Y, Sang X, Zhang H, Wang K, Wang X, Zhao H
Theranostics 2021;11(10):4585-4598. Epub 2021 Mar 4 doi: 10.7150/thno.56539. PMID: 33754015Free PMC Article
Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H
Cell Rep 2019 Apr 23;27(4):1265-1276.e4. doi: 10.1016/j.celrep.2019.03.088. PMID: 31018139
Molecular genetics and targeted therapeutics in biliary tract carcinoma.
Marks EI, Yee NS
World J Gastroenterol 2016 Jan 28;22(4):1335-47. doi: 10.3748/wjg.v22.i4.1335. PMID: 26819503Free PMC Article
Significance of keratinocyte growth factor receptor in the proliferation of biliary tract cancer.
Amano R, Yamada N, Doi Y, Yashiro M, Ohira M, Miwa A, Hirakawa K
Anticancer Res 2010 Oct;30(10):4115-21. PMID: 21036728

Clinical prediction guides

Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool.
Ma Y, Pan Y, Li Y, Guan H, Dai G
J Cancer Res Clin Oncol 2024 May 9;150(5):247. doi: 10.1007/s00432-024-05771-w. PMID: 38722378Free PMC Article
Prognostic significance of tumor budding in biliary tract cancer.
Regmi P, Paudyal A, Paudyal P, Hu HJ, Liu F, Ma WJ, Jin YW, Li FY
Eur J Surg Oncol 2022 Jan;48(1):160-168. Epub 2021 Aug 13 doi: 10.1016/j.ejso.2021.08.008. PMID: 34412954
Mutational spectrum and precision oncology for biliary tract carcinoma.
Lin J, Cao Y, Yang X, Li G, Shi Y, Wang D, Long J, Song Y, Mao J, Xie F, Bai Y, Zhang L, Yang X, Wan X, Wang A, Guan M, Zhao L, Hu K, Pan J, Huo L, Lu X, Mao Y, Sang X, Zhang H, Wang K, Wang X, Zhao H
Theranostics 2021;11(10):4585-4598. Epub 2021 Mar 4 doi: 10.7150/thno.56539. PMID: 33754015Free PMC Article
Molecular genetics and targeted therapeutics in biliary tract carcinoma.
Marks EI, Yee NS
World J Gastroenterol 2016 Jan 28;22(4):1335-47. doi: 10.3748/wjg.v22.i4.1335. PMID: 26819503Free PMC Article
Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction (Review).
Tsuchida A, Itoi T, Aoki T, Koyanagi Y
Oncol Rep 2003 Nov-Dec;10(6):1693-9. doi: 10.3892/or.10.6.1693. PMID: 14534681

Recent systematic reviews

Prognostic significance of tumor budding in biliary tract cancer.
Regmi P, Paudyal A, Paudyal P, Hu HJ, Liu F, Ma WJ, Jin YW, Li FY
Eur J Surg Oncol 2022 Jan;48(1):160-168. Epub 2021 Aug 13 doi: 10.1016/j.ejso.2021.08.008. PMID: 34412954
Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract.
Roos E, Soer EC, Klompmaker S, Meijer LL, Besselink MG, Giovannetti E, Heger M, Kazemier G, Klümpen HJ, Takkenberg RB, Wilmink H, Würdinger T, Dijk F, van Gulik TM, Verheij J, van de Vijver MJ
Crit Rev Oncol Hematol 2019 Aug;140:8-16. Epub 2019 May 24 doi: 10.1016/j.critrevonc.2019.05.011. PMID: 31158800
The Diagnostic Value of Pyruvate Kinase Isoenzyme Type M2 for Biliary Tract Carcinoma. A Systematic Review and Meta-Analysis.
Wang WQ, Liu W, Zhang N, Wang PH, Cao JZ, Chen JM, Li BL, He XD
J Gastrointestin Liver Dis 2018 Mar;27(1):73-81. doi: 10.15403/jgld.2014.1121.271.wqw. PMID: 29557418

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