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Gallbladder signet ring cell adenocarcinoma

MedGen UID:
232228
•Concept ID:
C1333758
•
Neoplastic Process
Synonyms: gall bladder signet ring cell carcinoma; gallbladder signet ring cell adenocarcinoma; Gallbladder Signet Ring Cell Carcinoma; gallbladder signet Ring cell carcinoma; Gallbladder Signet-Ring Cell Carcinoma; Signet Ring Cell Carcinoma of Gallbladder; signet Ring cell carcinoma of gallbladder; Signet Ring Cell Carcinoma of the Gallbladder; signet Ring cell carcinoma of the gallbladder
 
Monarch Initiative: MONDO:0002667

Definition

An adenocarcinoma that arises from the gallbladder. It is characterized by the presence of signet ring malignant epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder signet ring cell adenocarcinoma

Recent clinical studies

Etiology

Unmasking the silent killer: The hidden aggressiveness of signet-ring cell carcinoma in gallbladder cancer.
Cheng Z, Jia Z, Li X, Chen L, Cai Y
Biosci Trends 2024 Sep 16;18(4):379-387. Epub 2024 Aug 25 doi: 10.5582/bst.2024.01230. PMID: 39183029
Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder.
Wang S, Li J, You J, Zhou Y
BMC Gastroenterol 2021 Jun 6;21(1):248. doi: 10.1186/s12876-021-01831-4. PMID: 34090347Free PMC Article
Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis.
Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q
Expert Rev Gastroenterol Hepatol 2018 Feb;12(2):209-214. Epub 2017 Dec 17 doi: 10.1080/17474124.2018.1416291. PMID: 29227748
Unusual malignant epithelial tumors of the gallbladder.
Albores-Saavedra J, Molberg K, Henson DE
Semin Diagn Pathol 1996 Nov;13(4):326-38. PMID: 8946610

Diagnosis

Unmasking the silent killer: The hidden aggressiveness of signet-ring cell carcinoma in gallbladder cancer.
Cheng Z, Jia Z, Li X, Chen L, Cai Y
Biosci Trends 2024 Sep 16;18(4):379-387. Epub 2024 Aug 25 doi: 10.5582/bst.2024.01230. PMID: 39183029
EGFR Expression in Gallbladder Carcinoma in North Indian Population.
Vikash, Kailashiya V, Kumar M, Puneet
Gulf J Oncolog 2023 May;1(42):47-52. PMID: 37283260
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.
Turashvili G, Samore WR, Oliva E, Ioffe O, Riddell R, Park KJ, Horn LC
Am J Surg Pathol 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. PMID: 32910021Free PMC Article
Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis.
Ragazzi M, Carbonara C, Rosai J
Hum Pathol 2009 Mar;40(3):326-31. Epub 2008 Oct 29 doi: 10.1016/j.humpath.2008.07.016. PMID: 18973921
Signet-ring cell aggregates simulating carcinoma in colon and gallbladder mucosa.
Michal M, Chlumska A, Mukensnabl P
Pathol Res Pract 1998;194(3):197-200. doi: 10.1016/S0344-0338(98)80023-X. PMID: 9587939

Therapy

Signet-Ring Cell Carcinoma of the Gallbladder after Gastric Bypass.
Snyder JA, Carman R Jr, DiMarco L
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S67-9. doi: 10.1007/s12029-011-9301-1. PMID: 21727994
A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature.
Jain V, Gupta K, Kudva R, Rodrigues GS
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:319-21. doi: 10.1111/j.1525-1438.2006.00335.x. PMID: 16515613
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
Nabeshima S, Kishihara Y, Nabeshima A, Yamaga S, Kinjo M, Kashiwagi S, Hayashi J
Fukuoka Igaku Zasshi 2003 Jul;94(7):235-40. PMID: 14509231
Efficacy of gemcitabine in the treatment of patients with gallbladder carcinoma: a case report.
Castro MP
Cancer 1998 Feb 15;82(4):639-41. doi: 10.1002/(sici)1097-0142(19980215)82:4<639::aid-cncr4>3.0.co;2-g. PMID: 9477094
Gallbladder cancer and trocar site recurrences.
Ricardo AE, Feig BW, Ellis LM, Hunt KK, Curley SA, MacFadyen BV Jr, Mansfield PF
Am J Surg 1997 Dec;174(6):619-22; discussion 622-3. doi: 10.1016/s0002-9610(97)00178-5. PMID: 9409585

Prognosis

Unmasking the silent killer: The hidden aggressiveness of signet-ring cell carcinoma in gallbladder cancer.
Cheng Z, Jia Z, Li X, Chen L, Cai Y
Biosci Trends 2024 Sep 16;18(4):379-387. Epub 2024 Aug 25 doi: 10.5582/bst.2024.01230. PMID: 39183029
EGFR Expression in Gallbladder Carcinoma in North Indian Population.
Vikash, Kailashiya V, Kumar M, Puneet
Gulf J Oncolog 2023 May;1(42):47-52. PMID: 37283260
Comparison of clinicopathological characteristics of mucinous adenocarcinoma and conventional adenocarcinoma of gallbladder.
Zou RQ, Hu HJ, Liu F, Lv TR, Wang JK, Regmi P, Li FY
Asian J Surg 2023 Jan;46(1):283-290. Epub 2022 Apr 11 doi: 10.1016/j.asjsur.2022.03.094. PMID: 35422386
Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder.
Wang S, Li J, You J, Zhou Y
BMC Gastroenterol 2021 Jun 6;21(1):248. doi: 10.1186/s12876-021-01831-4. PMID: 34090347Free PMC Article
Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis.
Wu SG, Chen XT, Zhang WW, Sun JY, Li FY, He ZY, Pei XQ, Lin Q
Expert Rev Gastroenterol Hepatol 2018 Feb;12(2):209-214. Epub 2017 Dec 17 doi: 10.1080/17474124.2018.1416291. PMID: 29227748

Clinical prediction guides

Unmasking the silent killer: The hidden aggressiveness of signet-ring cell carcinoma in gallbladder cancer.
Cheng Z, Jia Z, Li X, Chen L, Cai Y
Biosci Trends 2024 Sep 16;18(4):379-387. Epub 2024 Aug 25 doi: 10.5582/bst.2024.01230. PMID: 39183029
Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder.
Wang S, Li J, You J, Zhou Y
BMC Gastroenterol 2021 Jun 6;21(1):248. doi: 10.1186/s12876-021-01831-4. PMID: 34090347Free PMC Article
Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.
Turashvili G, Samore WR, Oliva E, Ioffe O, Riddell R, Park KJ, Horn LC
Am J Surg Pathol 2020 Dec;44(12):1699-1711. doi: 10.1097/PAS.0000000000001578. PMID: 32910021Free PMC Article
Signet-ring cell carcinoma of the gallbladder complicated by pulmonary tumor thrombotic microangiopathy.
Ohno Y, Kumagi T, Kuroda T, Koizumi M, Azemoto N, Yamanishi H, Oda M, Hirooka M, Abe M, Ikeda Y, Matsuura B, Onji M, Soga Y, Mizuno Y, Sugita A, Hiasa Y
Intern Med 2014;53(11):1125-9. Epub 2014 Jun 1 doi: 10.2169/internalmedicine.53.1939. PMID: 24881735
A human gall-bladder signet ring cell carcinoma cell line.
Nishida T, Iwasaki H, Johzaki H, Tanaka S, Watanabe R, Kikuchi M
Pathol Int 1997 Jun;47(6):368-76. doi: 10.1111/j.1440-1827.1997.tb04510.x. PMID: 9211524

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