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Gallbladder Large Cell Neuroendocrine Carcinoma

MedGen UID:
473514
•Concept ID:
C2010353
•
Neoplastic Process
Synonym: Gallbladder Large Cell NEC

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Regional treatment of hepatic metastases and hepatocellular carcinoma.
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812

Recent clinical studies

Etiology

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Repeat liver resection for pure large cell neuroendocrine carcinoma of the gallbladder: a favorable outcome.
Abutaka A, El-Matbouly M, Helmy I, Elmoghazy W, Sulieman I, Ben Gashir M, Soofi M, Khalaf H, Elaffandi A
World J Surg Oncol 2019 Jul 20;17(1):126. doi: 10.1186/s12957-019-1666-9. PMID: 31325969Free PMC Article
Large cell neuroendocrine carcinoma and adenocarcinoma of gallbladder with concomitant hepatitis C infection.
Soin S, Pannu BS, Myint PT, Dhillon AS
BMJ Case Rep 2018 Jun 28;2018 doi: 10.1136/bcr-2018-225141. PMID: 29954768Free PMC Article
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508
Merkel cell carcinoma and multiple primary cancers.
Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1545-9. doi: 10.1158/1055-9965.EPI-05-0895. PMID: 16896047

Diagnosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Staying on Tract in a Patient With Right Upper Quadrant Pain and a Cholecystostomy Tube.
Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Somatostatinomas, PPomas, neurotensinomas.
Vinik AI, Strodel WE, Eckhauser FE, Moattari AR, Lloyd R
Semin Oncol 1987 Sep;14(3):263-81. PMID: 2820062

Therapy

Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention.
Giraldo NA, Drill E, Satravada BA, Dika IE, Brannon AR, Dermawan J, Mohanty A, Ozcan K, Chakravarty D, Benayed R, Vakiani E, Abou-Alfa GK, Kundra R, Schultz N, Li BT, Berger MF, Harding JJ, Ladanyi M, O'Reilly EM, Jarnagin W, Vanderbilt C, Basturk O, Arcila ME
Clin Cancer Res 2022 Dec 15;28(24):5359-5367. doi: 10.1158/1078-0432.CCR-22-1954. PMID: 36228155Free PMC Article
Staying on Tract in a Patient With Right Upper Quadrant Pain and a Cholecystostomy Tube.
Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment.
Shimono C, Suwa K, Sato M, Shirai S, Yamada K, Nakamura Y, Makuuchi M
Int J Clin Oncol 2009 Aug;14(4):351-5. Epub 2009 Aug 25 doi: 10.1007/s10147-008-0843-6. PMID: 19705247
Neuroendocrine tumours of the gallbladder: three cases and a review of the literature.
Iype S, Mirza TA, Propper DJ, Bhattacharya S, Feakins RM, Kocher HM
Postgrad Med J 2009 Apr;85(1002):213-8. doi: 10.1136/pgmj.2008.070649. PMID: 19417172
Regional treatment of hepatic metastases and hepatocellular carcinoma.
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812

Prognosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention.
Giraldo NA, Drill E, Satravada BA, Dika IE, Brannon AR, Dermawan J, Mohanty A, Ozcan K, Chakravarty D, Benayed R, Vakiani E, Abou-Alfa GK, Kundra R, Schultz N, Li BT, Berger MF, Harding JJ, Ladanyi M, O'Reilly EM, Jarnagin W, Vanderbilt C, Basturk O, Arcila ME
Clin Cancer Res 2022 Dec 15;28(24):5359-5367. doi: 10.1158/1078-0432.CCR-22-1954. PMID: 36228155Free PMC Article
Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Staying on Tract in a Patient With Right Upper Quadrant Pain and a Cholecystostomy Tube.
Law J, Zhornitskiy A, Tabibian JH
Gastroenterology 2020 Apr;158(5):e7-e9. Epub 2019 Nov 15 doi: 10.1053/j.gastro.2019.10.045. PMID: 31738916
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article

Clinical prediction guides

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder.
Liu F, Li Y, Ying D, Qiu S, He Y, Li M, Liu Y, Zhang Y, Zhu Q, Hu Y, Liu L, Li G, Pan W, Jin W, Mu J, Cao Y, Liu Y
Signal Transduct Target Ther 2021 Feb 10;6(1):55. doi: 10.1038/s41392-020-00412-3. PMID: 33563892Free PMC Article
Neuroendocrine Carcinomas of the Gallbladder: A Clinicopathologic and Immunohistochemical Analysis of 34 Resected Cases.
Lee SM, Sung CO
Am J Surg Pathol 2020 Oct;44(10):1308-1321. doi: 10.1097/PAS.0000000000001536. PMID: 32739935
Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature.
Liu W, Wang L, He XD, Feng C, Chang XY, Lu ZH
World J Surg Oncol 2015 Mar 18;13:114. doi: 10.1186/s12957-015-0533-6. PMID: 25890047Free PMC Article
Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
Sato K, Imai T, Shirota Y, Ueda Y, Katsuda S
Pathol Res Pract 2010 Jun 15;206(6):397-400. Epub 2009 Nov 27 doi: 10.1016/j.prp.2009.10.008. PMID: 19945229
Merkel cell carcinoma and multiple primary cancers.
Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1545-9. doi: 10.1158/1055-9965.EPI-05-0895. PMID: 16896047

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