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Extrahepatic bile duct carcinoma

MedGen UID:
116036
•Concept ID:
C0238019
•
Neoplastic Process
Synonyms: Carcinoma of extrahepatic bile duct; Carcinoma of Extrahepatic Bile Duct; carcinoma of extrahepatic bile duct; Carcinoma of the Extrahepatic Bile Duct; carcinoma of the extrahepatic bile duct; Extrahepatic Bile Duct Cancer; extrahepatic bile duct cancer; Extrahepatic Bile Duct Carcinoma; extrahepatic bile duct carcinoma
SNOMED CT: Carcinoma of extrahepatic bile duct (372101000)
 
Monarch Initiative: MONDO:0003090

Definition

A carcinoma that arises from the extrahepatic bile ducts. The majority are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic bile duct carcinoma

Professional guidelines

PubMed

Bile cytology diagnosis in challenging cases: Validation of diagnostic bile cytology criteria and extensive study for immunocytochemical markers.
Sano N, Tabata K, Oda T, Yanagita M, Suzuki T, Komatsubara T, Kawata H, Fukushima N
Diagn Cytopathol 2022 Mar;50(3):123-132. Epub 2022 Jan 4 doi: 10.1002/dc.24930. PMID: 34981669
Palliative treatment for bile duct carcinoma.
Safioleas M, Mantas D, Kakisis J, Manti C, Kouraklis G, Kostakis A
Hepatogastroenterology 2003 May-Jun;50(51):636-8. PMID: 12828049
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma.
Foo ML, Gunderson LL, Bender CE, Buskirk SJ
Int J Radiat Oncol Biol Phys 1997 Nov 1;39(4):929-35. doi: 10.1016/s0360-3016(97)00299-x. PMID: 9369143

Recent clinical studies

Etiology

Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.
Jun SY, Hong SM, An S
Pathobiology 2024;91(4):254-267. Epub 2023 Dec 19 doi: 10.1159/000535847. PMID: 38113866Free PMC Article
EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.
Moon A, Chin S, Kim HK, Kwak JJ, Koh ES, Kim YW, Jang KT
Pathology 2016 Jan;48(1):35-40. Epub 2015 Dec 12 doi: 10.1016/j.pathol.2015.11.011. PMID: 27020207
Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential.
Yoshizawa T, Toyoki Y, Hirai H, Haga T, Toba T, Sakuraba S, Okano K, Wu Y, Seino H, Morohashi S, Hakamada K, Kijima H
Oncol Rep 2014 Oct;32(4):1355-61. Epub 2014 Aug 7 doi: 10.3892/or.2014.3394. PMID: 25109922Free PMC Article
Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902
Diagnostic and surgical therapeutic features of extrahepatic bile duct carcinoma without jaundice.
Tang HH, Chang S, Wang XW, Huang Y, Gong XJ, Zhou J
World J Gastroenterol 2004 Oct 15;10(20):3060-1. doi: 10.3748/wjg.v10.i20.3060. PMID: 15378794Free PMC Article

Diagnosis

Novel Biomarker Panels Discriminating between Pancreatic Ductal Adenocarcinoma and Extrahepatic Bile Duct Carcinoma.
Noh BJ, Choi GM, Jang HJ, Ma CH, Oh HS, Kim M, Eom DW
Ann Clin Lab Sci 2022 Mar;52(2):323-331. PMID: 35414511
Bile cytology diagnosis in challenging cases: Validation of diagnostic bile cytology criteria and extensive study for immunocytochemical markers.
Sano N, Tabata K, Oda T, Yanagita M, Suzuki T, Komatsubara T, Kawata H, Fukushima N
Diagn Cytopathol 2022 Mar;50(3):123-132. Epub 2022 Jan 4 doi: 10.1002/dc.24930. PMID: 34981669
Cholangiocarcinoma miscoding in hepatobiliary centres.
Selvadurai S, Mann K, Mithra S, Bridgewater J, Malik H, Khan SA
Eur J Surg Oncol 2021 Mar;47(3 Pt B):635-639. Epub 2020 Oct 1 doi: 10.1016/j.ejso.2020.09.039. PMID: 33032867
EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.
Moon A, Chin S, Kim HK, Kwak JJ, Koh ES, Kim YW, Jang KT
Pathology 2016 Jan;48(1):35-40. Epub 2015 Dec 12 doi: 10.1016/j.pathol.2015.11.011. PMID: 27020207
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma.
Foo ML, Gunderson LL, Bender CE, Buskirk SJ
Int J Radiat Oncol Biol Phys 1997 Nov 1;39(4):929-35. doi: 10.1016/s0360-3016(97)00299-x. PMID: 9369143

Therapy

Influence of bile contamination for patients who undergo pancreaticoduodenectomy after biliary drainage.
Okano K, Suzuki Y
World J Gastroenterol 2019 Dec 21;25(47):6847-6856. doi: 10.3748/wjg.v25.i47.6847. PMID: 31885425Free PMC Article
Evaluation of preoperative risk factors for postpancreatectomy hemorrhage.
Izumo W, Higuchi R, Yazawa T, Uemura S, Shiihara M, Yamamoto M
Langenbecks Arch Surg 2019 Dec;404(8):967-974. Epub 2019 Oct 24 doi: 10.1007/s00423-019-01830-w. PMID: 31650216Free PMC Article
Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902
Thermo-chemo-radiotherapy for advanced bile duct carcinoma.
Kamisawa T, Tu Y, Egawa N, Karasawa K, Matsuda T, Tsuruta K, Okamoto A
World J Gastroenterol 2005 Jul 21;11(27):4206-9. doi: 10.3748/wjg.v11.i27.4206. PMID: 16015690Free PMC Article
External radiation therapy and transcatheter iridium in the treatment of extrahepatic bile duct carcinoma.
Foo ML, Gunderson LL, Bender CE, Buskirk SJ
Int J Radiat Oncol Biol Phys 1997 Nov 1;39(4):929-35. doi: 10.1016/s0360-3016(97)00299-x. PMID: 9369143

Prognosis

Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.
Jun SY, Hong SM, An S
Pathobiology 2024;91(4):254-267. Epub 2023 Dec 19 doi: 10.1159/000535847. PMID: 38113866Free PMC Article
The T Category of Distal Extrahepatic Bile Duct Carcinoma: A Comparative Analysis With Invasive Tumor Thickness.
Jun SY, Shin JH, Chun J, Kang HJ, Hong SM
Am J Surg Pathol 2022 Jul 1;46(7):907-920. Epub 2022 Mar 15 doi: 10.1097/PAS.0000000000001884. PMID: 35288524
Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.
Jun SY, An S, Huh T, Chung JY, Hong SM
Pathol Res Pract 2020 May;216(5):152940. Epub 2020 Mar 27 doi: 10.1016/j.prp.2020.152940. PMID: 32276789
Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential.
Yoshizawa T, Toyoki Y, Hirai H, Haga T, Toba T, Sakuraba S, Okano K, Wu Y, Seino H, Morohashi S, Hakamada K, Kijima H
Oncol Rep 2014 Oct;32(4):1355-61. Epub 2014 Aug 7 doi: 10.3892/or.2014.3394. PMID: 25109922Free PMC Article
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286

Clinical prediction guides

Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.
Jun SY, Hong SM, An S
Pathobiology 2024;91(4):254-267. Epub 2023 Dec 19 doi: 10.1159/000535847. PMID: 38113866Free PMC Article
The T Category of Distal Extrahepatic Bile Duct Carcinoma: A Comparative Analysis With Invasive Tumor Thickness.
Jun SY, Shin JH, Chun J, Kang HJ, Hong SM
Am J Surg Pathol 2022 Jul 1;46(7):907-920. Epub 2022 Mar 15 doi: 10.1097/PAS.0000000000001884. PMID: 35288524
Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma.
Jun SY, An S, Huh T, Chung JY, Hong SM
Pathol Res Pract 2020 May;216(5):152940. Epub 2020 Mar 27 doi: 10.1016/j.prp.2020.152940. PMID: 32276789
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286
Diagnostic and surgical therapeutic features of extrahepatic bile duct carcinoma without jaundice.
Tang HH, Chang S, Wang XW, Huang Y, Gong XJ, Zhou J
World J Gastroenterol 2004 Oct 15;10(20):3060-1. doi: 10.3748/wjg.v10.i20.3060. PMID: 15378794Free PMC Article

Recent systematic reviews

Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902

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