U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Gallbladder Carcinoma

MedGen UID:
1705816
•Concept ID:
C5206798
•
Neoplastic Process

Definition

Gallbladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Gallbladder Carcinoma

Professional guidelines

PubMed

Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Staging, Treatment, and Future Approaches of Gallbladder Carcinoma.
Shukla SK, Singh G, Shahi KS, Bhuvan, Pant P
J Gastrointest Cancer 2018 Mar;49(1):9-15. doi: 10.1007/s12029-017-0036-5. PMID: 29234972

Recent clinical studies

Etiology

High predictive ability of apparent diffusion coefficient value for wall-invasion pattern of advanced gallbladder carcinoma.
Koga T, Ishida Y, Hamada Y, Takayama Y, Tsuchiya N, Kitaguchi T, Matsumoto K, Kajiwara M, Naito S, Ishii F, Nakashima R, Sasaki T, Hirai F
Abdom Radiol (NY) 2023 Mar;48(3):902-912. Epub 2023 Jan 24 doi: 10.1007/s00261-023-03805-4. PMID: 36694054
Correlation of Prognostic Markers {CEA, Ca19.9, Neutrophil To Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)} With Progression Free Survival (PFS) in Advanced/Metastatic Gallbladder Carcinoma.
Naik MD, Kataria SP, Kumar G, Singh R
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443542
Xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma - Analysis of 8 cases.
Khan S, Abeer I, Husain M, Hassan MJ, Jetley S
J Cancer Res Ther 2021 Jul-Sep;17(4):969-975. doi: 10.4103/jcrt.JCRT_1180_19. PMID: 34528550
Combined extrahepatic bile duct resection for locally advanced gallbladder carcinoma: does it work?
Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Nagino M
World J Surg 2015 Jul;39(7):1810-7. doi: 10.1007/s00268-015-3011-y. PMID: 25663014
Surgical strategies in patients with gallbladder cancer: nihilism to optimism.
Sikora SS, Singh RK
J Surg Oncol 2006 Jun 15;93(8):670-81. doi: 10.1002/jso.20535. PMID: 16724356

Diagnosis

High predictive ability of apparent diffusion coefficient value for wall-invasion pattern of advanced gallbladder carcinoma.
Koga T, Ishida Y, Hamada Y, Takayama Y, Tsuchiya N, Kitaguchi T, Matsumoto K, Kajiwara M, Naito S, Ishii F, Nakashima R, Sasaki T, Hirai F
Abdom Radiol (NY) 2023 Mar;48(3):902-912. Epub 2023 Jan 24 doi: 10.1007/s00261-023-03805-4. PMID: 36694054
Correlation of Prognostic Markers {CEA, Ca19.9, Neutrophil To Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)} With Progression Free Survival (PFS) in Advanced/Metastatic Gallbladder Carcinoma.
Naik MD, Kataria SP, Kumar G, Singh R
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443542
Xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma - Analysis of 8 cases.
Khan S, Abeer I, Husain M, Hassan MJ, Jetley S
J Cancer Res Ther 2021 Jul-Sep;17(4):969-975. doi: 10.4103/jcrt.JCRT_1180_19. PMID: 34528550
MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells.
Liu X, Huang J, Liu L, Liu R
Mol Med Rep 2019 Sep;20(3):2725-2733. Epub 2019 Jul 18 doi: 10.3892/mmr.2019.10506. PMID: 31322261Free PMC Article
Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: A case report and review of literature.
Spinelli A, Schumacher G, Pascher A, Lopez-Hanninen E, Al-Abadi H, Benckert C, Sauer IM, Pratschke J, Neumann UP, Jonas S, Langrehr JM, Neuhaus P
World J Gastroenterol 2006 Apr 14;12(14):2293-6. doi: 10.3748/wjg.v12.i14.2293. PMID: 16610041Free PMC Article

Therapy

Correlation of Prognostic Markers {CEA, Ca19.9, Neutrophil To Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)} With Progression Free Survival (PFS) in Advanced/Metastatic Gallbladder Carcinoma.
Naik MD, Kataria SP, Kumar G, Singh R
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443542
MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC‑SD cells.
Liu X, Huang J, Liu L, Liu R
Mol Med Rep 2019 Sep;20(3):2725-2733. Epub 2019 Jul 18 doi: 10.3892/mmr.2019.10506. PMID: 31322261Free PMC Article
Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes.
Creasy JM, Goldman DA, Dudeja V, Lowery MA, Cercek A, Balachandran VP, Allen PJ, DeMatteo RP, Kingham TP, D'Angelica MI, Jarnagin WR
J Am Coll Surg 2017 May;224(5):906-916. Epub 2017 Feb 13 doi: 10.1016/j.jamcollsurg.2016.12.058. PMID: 28216422Free PMC Article
Surgical outcomes of minor hepatectomy for locally advanced gallbladder carcinoma.
Wakai T, Shirai Y, Sakata J, Tsuchiya Y, Nomura T, Hatakeyama K
Hepatogastroenterology 2012 Oct;59(119):2083-8. doi: 10.5754/hge12097. PMID: 22456433
Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma.
Qin TJ, Zhao XH, Yun J, Zhang LX, Ruan ZP, Pan BR
World J Gastroenterol 2008 Sep 7;14(33):5210-6. doi: 10.3748/wjg.14.5210. PMID: 18777599Free PMC Article

Prognosis

Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis.
Xie L, Ning Z, Hua Y, Wang P, Meng Z
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000131. PMID: 37058121Free PMC Article
High predictive ability of apparent diffusion coefficient value for wall-invasion pattern of advanced gallbladder carcinoma.
Koga T, Ishida Y, Hamada Y, Takayama Y, Tsuchiya N, Kitaguchi T, Matsumoto K, Kajiwara M, Naito S, Ishii F, Nakashima R, Sasaki T, Hirai F
Abdom Radiol (NY) 2023 Mar;48(3):902-912. Epub 2023 Jan 24 doi: 10.1007/s00261-023-03805-4. PMID: 36694054
Correlation of Prognostic Markers {CEA, Ca19.9, Neutrophil To Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)} With Progression Free Survival (PFS) in Advanced/Metastatic Gallbladder Carcinoma.
Naik MD, Kataria SP, Kumar G, Singh R
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443542
Xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma - Analysis of 8 cases.
Khan S, Abeer I, Husain M, Hassan MJ, Jetley S
J Cancer Res Ther 2021 Jul-Sep;17(4):969-975. doi: 10.4103/jcrt.JCRT_1180_19. PMID: 34528550
Immunohistochemically demonstrated lymph node micrometastasis and prognosis in patients with gallbladder carcinoma.
Sasaki E, Nagino M, Ebata T, Oda K, Arai T, Nishio H, Nimura Y
Ann Surg 2006 Jul;244(1):99-105. doi: 10.1097/01.sla.0000217675.22495.6f. PMID: 16794394Free PMC Article

Clinical prediction guides

Single-cell transcriptome analysis revealed the immune profile of PD-1 blockade in gallbladder carcinoma liver metastasis.
Xie L, Ning Z, Hua Y, Wang P, Meng Z
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000131. PMID: 37058121Free PMC Article
High predictive ability of apparent diffusion coefficient value for wall-invasion pattern of advanced gallbladder carcinoma.
Koga T, Ishida Y, Hamada Y, Takayama Y, Tsuchiya N, Kitaguchi T, Matsumoto K, Kajiwara M, Naito S, Ishii F, Nakashima R, Sasaki T, Hirai F
Abdom Radiol (NY) 2023 Mar;48(3):902-912. Epub 2023 Jan 24 doi: 10.1007/s00261-023-03805-4. PMID: 36694054
Correlation of Prognostic Markers {CEA, Ca19.9, Neutrophil To Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)} With Progression Free Survival (PFS) in Advanced/Metastatic Gallbladder Carcinoma.
Naik MD, Kataria SP, Kumar G, Singh R
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443542
Xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma - Analysis of 8 cases.
Khan S, Abeer I, Husain M, Hassan MJ, Jetley S
J Cancer Res Ther 2021 Jul-Sep;17(4):969-975. doi: 10.4103/jcrt.JCRT_1180_19. PMID: 34528550
Reg IV expression and clinicopathologic features of gallbladder carcinoma.
Tamura H, Ohtsuka M, Washiro M, Kimura F, Shimizu H, Yoshidome H, Kato A, Seki N, Miyazaki M
Hum Pathol 2009 Dec;40(12):1686-92. Epub 2009 Aug 27 doi: 10.1016/j.humpath.2009.06.001. PMID: 19716164

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity