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Gallbladder Hepatoid Adenocarcinoma

MedGen UID:
473518
•Concept ID:
C2030691
•
Neoplastic Process

Definition

A rare variant of gallbladder adenocarcinoma. It is characterized by the presence of a malignant glandular epithelial infiltrate that resembles hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Hepatoid Adenocarcinoma

Recent clinical studies

Etiology

Albumin In Situ Hybridization Can Be Positive in Adenocarcinomas and Other Tumors From Diverse Sites.
Nasir A, Lehrke HD, Mounajjed T, Said S, Zhang L, Yasir S, Shah SS, Chandan VS, Smyrk TC, Moreira RK, Boland Froemming JM, Herrera Hernandez LP, Wu TT, Graham RP
Am J Clin Pathol 2019 Jul 5;152(2):190-199. doi: 10.1093/ajcp/aqz032. PMID: 31107526
Hepatoid adenocarcinoma of the gallbladder.
Nakashima H, Nagafuchi K, Satoh H, Takeda K, Yamasaki T, Yonemasu H, Kishikawa H
J Hepatobiliary Pancreat Surg 2000;7(2):226-30. doi: 10.1007/s005340050181. PMID: 10982619

Diagnosis

Metastatic mediastinal hepatoid adenocarcinoma.
Caruana G, Cachia R, Micallef S, Sammut M, Psaila J
BMJ Case Rep 2024 Apr 9;17(4) doi: 10.1136/bcr-2022-253747. PMID: 38594200Free PMC Article
Cytological features of hepatoid adenocarcinoma of the gallbladder: A case report with immunocytochemical analyzes.
Yoshioka S, Ishida M, Okano K, Sandoh K, Ebisu Y, Miyasaka C, Yamamoto T, Ryota H, Satoi S, Tsuta K
Diagn Cytopathol 2018 Aug;46(8):711-715. Epub 2018 Apr 10 doi: 10.1002/dc.23935. PMID: 29637715
Hepatoid adenocarcinoma of the gallbladder.
Ellouze S, Slim C, Ahmad G, Naourez G, Ali A, Héla M, Mariem K, Mohamed BA, Tahia B
World J Surg Oncol 2011 Sep 13;9:103. doi: 10.1186/1477-7819-9-103. PMID: 21914163Free PMC Article
Hepatoid adenocarcinoma of the gallbladder.
Gakiopoulou H, Givalos N, Liapis G, Agrogiannis G, Patsouris E, Delladetsima I
Dig Dis Sci 2007 Dec;52(12):3358-62. Epub 2007 May 18 doi: 10.1007/s10620-007-9807-3. PMID: 17510803
Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature.
Sakamoto K, Monobe Y, Kouno M, Moriya T, Sasano H
Pathol Int 2004 Jan;54(1):52-6. doi: 10.1111/j.1440-1827.2004.01578.x. PMID: 14674996

Therapy

Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity.
Metzgeroth G, Ströbel P, Baumbusch T, Reiter A, Hastka J
Onkologie 2010;33(5):263-9. Epub 2010 Apr 13 doi: 10.1159/000305717. PMID: 20502062

Prognosis

Cytological features of hepatoid adenocarcinoma of the gallbladder: A case report with immunocytochemical analyzes.
Yoshioka S, Ishida M, Okano K, Sandoh K, Ebisu Y, Miyasaka C, Yamamoto T, Ryota H, Satoi S, Tsuta K
Diagn Cytopathol 2018 Aug;46(8):711-715. Epub 2018 Apr 10 doi: 10.1002/dc.23935. PMID: 29637715
Hepatoid Adenocarcinoma of the Gallbladder : Case Report and Literature Review.
Karayiannakis AJ, Kakolyris S, Giatromanolaki A, Courcoutsakis N, Bolanaki H, Chelis L, Sivridis E, Simopoulos C
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S139-44. doi: 10.1007/s12029-011-9326-5. PMID: 21935757
Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity.
Metzgeroth G, Ströbel P, Baumbusch T, Reiter A, Hastka J
Onkologie 2010;33(5):263-9. Epub 2010 Apr 13 doi: 10.1159/000305717. PMID: 20502062
Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature.
Sakamoto K, Monobe Y, Kouno M, Moriya T, Sasano H
Pathol Int 2004 Jan;54(1):52-6. doi: 10.1111/j.1440-1827.2004.01578.x. PMID: 14674996
Hepatoid adenocarcinoma of the gallbladder.
Nakashima H, Nagafuchi K, Satoh H, Takeda K, Yamasaki T, Yonemasu H, Kishikawa H
J Hepatobiliary Pancreat Surg 2000;7(2):226-30. doi: 10.1007/s005340050181. PMID: 10982619

Clinical prediction guides

Enteroblastic cholangiocarcinoma: An uncommon, underrecognized subtype of bile duct cancer.
Chun J, Moore M, Kelly P, Kanzawa M, Itoh T, Hong SM, Zen Y
Hum Pathol 2024 Feb;144:46-52. Epub 2024 Jan 30 doi: 10.1016/j.humpath.2024.01.011. PMID: 38301963
Fetal gut-like differentiation in gallbladder cancer.
Koyama K, Maeda D, Tamura D, Narita C, Kudo-Asabe Y, Sato T, Yamamoto Y, Sageshima M, Nanjo H, Goto A
Hum Pathol 2017 Dec;70:27-34. Epub 2017 Sep 29 doi: 10.1016/j.humpath.2017.09.009. PMID: 28970139
Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein-producing lung tumor.
Arnould L, Drouot F, Fargeot P, Bernard A, Foucher P, Collin F, Petrella T
Am J Surg Pathol 1997 Sep;21(9):1113-8. doi: 10.1097/00000478-199709000-00018. PMID: 9298890

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