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Gallbladder carcinoma

MedGen UID:
116001
•Concept ID:
C0235782
•
Neoplastic Process
Synonym: Carcinoma of gallbladder
SNOMED CT: Carcinoma of gallbladder (372140005)
 
Monarch Initiative: MONDO:0003220

Definition

A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Gallbladder carcinoma
Follow this link to review classifications for Gallbladder carcinoma in Orphanet.

Professional guidelines

PubMed

Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT).
Roth GS, Verlingue L, Sarabi M, Blanc JF, Boleslawski E, Boudjema K, Bretagne-Bignon AL, Camus-Duboc M, Coriat R, Créhange G, De Baere T, de la Fouchardière C, Dromain C, Edeline J, Gelli M, Guiu B, Horn S, Laurent-Croise V, Lepage C, Lièvre A, Lopez A, Manfredi S, Meilleroux J, Neuzillet C, Paradis V, Prat F, Ronot M, Rosmorduc O, Cunha AS, Soubrane O, Turpin A, Louvet C, Bouché O, Malka D
Eur J Cancer 2024 May;202:114000. Epub 2024 Mar 13 doi: 10.1016/j.ejca.2024.114000. PMID: 38493667
Xanthogranulomatous cholecystitis: Diagnosis and management.
Giudicelli X, Rode A, Bancel B, Nguyen AT, Mabrut JY
J Visc Surg 2021 Aug;158(4):326-336. Epub 2021 Mar 23 doi: 10.1016/j.jviscsurg.2021.02.004. PMID: 33741306
Staging, Treatment, and Future Approaches of Gallbladder Carcinoma.
Shukla SK, Singh G, Shahi KS, Bhuvan, Pant P
J Gastrointest Cancer 2018 Mar;49(1):9-15. doi: 10.1007/s12029-017-0036-5. PMID: 29234972

Recent clinical studies

Etiology

Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
The Landmark Series: Gallbladder Cancer.
Gamboa AC, Maithel SK
Ann Surg Oncol 2020 Aug;27(8):2846-2858. Epub 2020 May 30 doi: 10.1245/s10434-020-08654-9. PMID: 32474816
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Choledochal Cyst and Malignancy: A Plea for Lifelong Follow-Up.
Madadi-Sanjani O, Wirth TC, Kuebler JF, Petersen C, Ure BM
Eur J Pediatr Surg 2019 Apr;29(2):143-149. Epub 2017 Dec 19 doi: 10.1055/s-0037-1615275. PMID: 29258149
Gallbladder carcinoma.
Miller G, Jarnagin WR
Eur J Surg Oncol 2008 Mar;34(3):306-12. Epub 2007 Oct 26 doi: 10.1016/j.ejso.2007.07.206. PMID: 17964753

Diagnosis

Gallbladder Cancer.
Marcinak CT, Abbott DE
Cancer Treat Res 2024;192:147-163. doi: 10.1007/978-3-031-61238-1_8. PMID: 39212920
Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Targeting the hedgehog pathway for gallbladder cancer therapy?
Mittal B, Yadav S
Chin Clin Oncol 2016 Feb;5(1):2. doi: 10.3978/j.issn.2304-3865.2015.12.03. PMID: 26932426
Genetic alteration regulated by microRNAs in biliary tract cancers.
Wang N, Xia S, Chen K, Xiang X, Zhu A
Crit Rev Oncol Hematol 2015 Nov;96(2):262-73. Epub 2015 Jun 4 doi: 10.1016/j.critrevonc.2015.05.015. PMID: 26095617
Gallbladder carcinoma.
Miller G, Jarnagin WR
Eur J Surg Oncol 2008 Mar;34(3):306-12. Epub 2007 Oct 26 doi: 10.1016/j.ejso.2007.07.206. PMID: 17964753

Therapy

A Practical Guide for the Systemic Treatment of Biliary Tract Cancer in Canada.
Ramjeesingh R, Chaudhury P, Tam VC, Roberge D, Lim HJ, Knox JJ, Asselah J, Doucette S, Chhiber N, Goodwin R
Curr Oncol 2023 Jul 25;30(8):7132-7150. doi: 10.3390/curroncol30080517. PMID: 37622998Free PMC Article
Multimodality Management of Localized Biliary Cancer.
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Targeting the hedgehog pathway for gallbladder cancer therapy?
Mittal B, Yadav S
Chin Clin Oncol 2016 Feb;5(1):2. doi: 10.3978/j.issn.2304-3865.2015.12.03. PMID: 26932426
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Current management of gallbladder carcinoma.
Zhu AX, Hong TS, Hezel AF, Kooby DA
Oncologist 2010;15(2):168-81. Epub 2010 Feb 10 doi: 10.1634/theoncologist.2009-0302. PMID: 20147507Free PMC Article

Prognosis

Current update on gallbladder carcinoma.
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Port site metastases after robot-assisted surgery: a systematic review.
Iavazzo C, Gkegkes ID
Int J Med Robot 2013 Dec;9(4):423-7. Epub 2013 Jun 3 doi: 10.1002/rcs.1512. PMID: 23733632
Current management of gallbladder carcinoma.
Zhu AX, Hong TS, Hezel AF, Kooby DA
Oncologist 2010;15(2):168-81. Epub 2010 Feb 10 doi: 10.1634/theoncologist.2009-0302. PMID: 20147507Free PMC Article
Gallbladder carcinoma.
Miller G, Jarnagin WR
Eur J Surg Oncol 2008 Mar;34(3):306-12. Epub 2007 Oct 26 doi: 10.1016/j.ejso.2007.07.206. PMID: 17964753

Clinical prediction guides

Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer.
Zhang Y, Zuo C, Liu L, Hu Y, Yang B, Qiu S, Li Y, Cao D, Ju Z, Ge J, Wang Q, Wang T, Bai L, Yang Y, Li G, Shao Z, Gao Y, Li Y, Bian R, Miao H, Li L, Li X, Jiang C, Yan S, Wang Z, Wang Z, Cui X, Huang W, Xiang D, Wang C, Li Q, Wu X, Gong W, Liu Y, Shao R, Liu F, Li M, Chen L, Liu Y
J Hepatol 2021 Nov;75(5):1128-1141. Epub 2021 Jun 23 doi: 10.1016/j.jhep.2021.06.023. PMID: 34171432
Epidemiological dimensions of the association between type 2 diabetes and cancer: A review of observational studies.
Sacerdote C, Ricceri F
Diabetes Res Clin Pract 2018 Sep;143:369-377. Epub 2018 Mar 27 doi: 10.1016/j.diabres.2018.03.002. PMID: 29596949
Genetic alteration regulated by microRNAs in biliary tract cancers.
Wang N, Xia S, Chen K, Xiang X, Zhu A
Crit Rev Oncol Hematol 2015 Nov;96(2):262-73. Epub 2015 Jun 4 doi: 10.1016/j.critrevonc.2015.05.015. PMID: 26095617
Tetrandrine induces apoptosis in gallbladder carcinoma in vitro.
Zhu R, Liu T, Tan Z, Wu X, Li M, Jiang L, Bao R, Shu Y, Lu A, Liu Y
Int J Clin Pharmacol Ther 2014 Oct;52(10):900-5. doi: 10.5414/CP202123. PMID: 25074868
Potential role of N-myristoyltransferase in cancer.
Selvakumar P, Lakshmikuttyamma A, Shrivastav A, Das SB, Dimmock JR, Sharma RK
Prog Lipid Res 2007 Jan;46(1):1-36. Epub 2006 Jun 12 doi: 10.1016/j.plipres.2006.05.002. PMID: 16846646

Recent systematic reviews

Prognostic factors for resected cases with gallbladder carcinoma: a systematic review and meta-analysis.
Lv TR, Wang JK, Li FY, Hu HJ
Int J Surg 2024 Jul 1;110(7):4342-4355. doi: 10.1097/JS9.0000000000001403. PMID: 38537060Free PMC Article
High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
The role of laparoscopic surgery in the surgical management of gallbladder carcinoma: A systematic review and meta-analysis.
Lv TR, Yang C, Regmi P, Ma WJ, Hu HJ, Liu F, Yin CH, Jin YW, Li FY
Asian J Surg 2021 Dec;44(12):1493-1502. Epub 2021 Apr 22 doi: 10.1016/j.asjsur.2021.03.015. PMID: 33895048
Port site metastases after robot-assisted surgery: a systematic review.
Iavazzo C, Gkegkes ID
Int J Med Robot 2013 Dec;9(4):423-7. Epub 2013 Jun 3 doi: 10.1002/rcs.1512. PMID: 23733632

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