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Recurrent Extrahepatic Bile Duct Carcinoma

MedGen UID:
78888
•Concept ID:
C0278812
•
Neoplastic Process
Synonyms: Recurrent Cancer of Extrahepatic Bile Duct; Recurrent Cancer of the Extrahepatic Bile Duct; Recurrent Extrahepatic Bile Duct Cancer; Relapsed Cancer of Extrahepatic Bile Duct; Relapsed Cancer of the Extrahepatic Bile Duct

Definition

The reemergence of an extrahepatic bile duct carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Extrahepatic Bile Duct Carcinoma

Professional guidelines

PubMed

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.
Spencer K, Pappas L, Baiev I, Maurer J, Bocobo AG, Zhang K, Jain A, De Armas AD, Reyes S, Le TM, Rahma OE, Stanton J, DeLeon TT, Roth M, Peters MLB, Zhu AX, Lennerz JK, Iafrate AJ, Boyhen K, VanCott C, Roberts LR, Lindsey S, Horick N, Goff LW, Mody K, Borad MJ, Shroff RT, Kelley RK, Javle MM, Goyal L
J Natl Cancer Inst 2023 Jul 6;115(7):870-880. doi: 10.1093/jnci/djad046. PMID: 37040087Free PMC Article
Update on the Diagnosis and Treatment of Cholangiocarcinoma.
Doherty B, Nambudiri VE, Palmer WC
Curr Gastroenterol Rep 2017 Jan;19(1):2. doi: 10.1007/s11894-017-0542-4. PMID: 28110453

Recent clinical studies

Etiology

Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.
Spencer K, Pappas L, Baiev I, Maurer J, Bocobo AG, Zhang K, Jain A, De Armas AD, Reyes S, Le TM, Rahma OE, Stanton J, DeLeon TT, Roth M, Peters MLB, Zhu AX, Lennerz JK, Iafrate AJ, Boyhen K, VanCott C, Roberts LR, Lindsey S, Horick N, Goff LW, Mody K, Borad MJ, Shroff RT, Kelley RK, Javle MM, Goyal L
J Natl Cancer Inst 2023 Jul 6;115(7):870-880. doi: 10.1093/jnci/djad046. PMID: 37040087Free PMC Article
Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma.
Akita M, Ajiki T, Ueno K, Tsugawa D, Tanaka M, Kido M, Toyama H, Fukumoto T
Hepatobiliary Pancreat Dis Int 2020 Apr;19(2):147-152. Epub 2020 Jan 30 doi: 10.1016/j.hbpd.2020.01.002. PMID: 32037277
Update on the Diagnosis and Treatment of Cholangiocarcinoma.
Doherty B, Nambudiri VE, Palmer WC
Curr Gastroenterol Rep 2017 Jan;19(1):2. doi: 10.1007/s11894-017-0542-4. PMID: 28110453
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Primary sclerosing cholangitis.
Milkiewicz P, Wunsch E
Recent Results Cancer Res 2011;185:117-33. doi: 10.1007/978-3-642-03503-6_7. PMID: 21822823

Diagnosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Bile detection of squamous cell carcinoma antigen (SCCA) in extrahepatic cholangiocarcinoma.
Gringeri E, Biasiolo A, Di Giunta M, Mescoli C, Guzzardo V, Sartori A, Cirillo G, Nieddu E, D'Amico FE, Pontisso P, Cillo U
Dig Liver Dis 2023 Apr;55(4):534-540. Epub 2022 Nov 8 doi: 10.1016/j.dld.2022.10.010. PMID: 36369195
Insights and updates on endoscopic papillectomy.
Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873
Update on the Diagnosis and Treatment of Cholangiocarcinoma.
Doherty B, Nambudiri VE, Palmer WC
Curr Gastroenterol Rep 2017 Jan;19(1):2. doi: 10.1007/s11894-017-0542-4. PMID: 28110453
Primary sclerosing cholangitis.
Milkiewicz P, Wunsch E
Recent Results Cancer Res 2011;185:117-33. doi: 10.1007/978-3-642-03503-6_7. PMID: 21822823

Therapy

Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.
Spencer K, Pappas L, Baiev I, Maurer J, Bocobo AG, Zhang K, Jain A, De Armas AD, Reyes S, Le TM, Rahma OE, Stanton J, DeLeon TT, Roth M, Peters MLB, Zhu AX, Lennerz JK, Iafrate AJ, Boyhen K, VanCott C, Roberts LR, Lindsey S, Horick N, Goff LW, Mody K, Borad MJ, Shroff RT, Kelley RK, Javle MM, Goyal L
J Natl Cancer Inst 2023 Jul 6;115(7):870-880. doi: 10.1093/jnci/djad046. PMID: 37040087Free PMC Article
Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma.
McMillan RR, Javle M, Kodali S, Saharia A, Mobley C, Heyne K, Hobeika MJ, Lunsford KE, Victor DW 3rd, Shetty A, McFadden RS, Abdelrahim M, Kaseb A, Divatia M, Yu N, Nolte Fong J, Moore LW, Nguyen DT, Graviss EA, Gaber AO, Vauthey JN, Ghobrial RM
Am J Transplant 2022 Mar;22(3):823-832. Epub 2021 Dec 27 doi: 10.1111/ajt.16906. PMID: 34856069
Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Insights and updates on endoscopic papillectomy.
Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.
Spencer K, Pappas L, Baiev I, Maurer J, Bocobo AG, Zhang K, Jain A, De Armas AD, Reyes S, Le TM, Rahma OE, Stanton J, DeLeon TT, Roth M, Peters MLB, Zhu AX, Lennerz JK, Iafrate AJ, Boyhen K, VanCott C, Roberts LR, Lindsey S, Horick N, Goff LW, Mody K, Borad MJ, Shroff RT, Kelley RK, Javle MM, Goyal L
J Natl Cancer Inst 2023 Jul 6;115(7):870-880. doi: 10.1093/jnci/djad046. PMID: 37040087Free PMC Article
Update on the Diagnosis and Treatment of Cholangiocarcinoma.
Doherty B, Nambudiri VE, Palmer WC
Curr Gastroenterol Rep 2017 Jan;19(1):2. doi: 10.1007/s11894-017-0542-4. PMID: 28110453
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873

Clinical prediction guides

Hepatoid carcinoma and related entities of the extrahepatic bile duct: A clinicopathological study of four cases.
Okura K, Esaki M, Nara S, Ban D, Takamoto T, Shimada K, Hiraoka N
Pathol Int 2022 Jun;72(6):332-342. Epub 2022 Apr 26 doi: 10.1111/pin.13226. PMID: 35472251
Chemoresistance and resistance to targeted therapies in biliary tract cancer: what have we learned?
Mayr C, Kiesslich T, Modest DP, Stintzing S, Ocker M, Neureiter D
Expert Opin Investig Drugs 2022 Feb;31(2):221-233. Epub 2022 Feb 7 doi: 10.1080/13543784.2022.2034785. PMID: 35098846
Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma.
McMillan RR, Javle M, Kodali S, Saharia A, Mobley C, Heyne K, Hobeika MJ, Lunsford KE, Victor DW 3rd, Shetty A, McFadden RS, Abdelrahim M, Kaseb A, Divatia M, Yu N, Nolte Fong J, Moore LW, Nguyen DT, Graviss EA, Gaber AO, Vauthey JN, Ghobrial RM
Am J Transplant 2022 Mar;22(3):823-832. Epub 2021 Dec 27 doi: 10.1111/ajt.16906. PMID: 34856069
Management of primary sclerosing cholangitis and its complications: an algorithmic approach.
Prokopič M, Beuers U
Hepatol Int 2021 Feb;15(1):6-20. Epub 2020 Dec 30 doi: 10.1007/s12072-020-10118-x. PMID: 33377990Free PMC Article
Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma.
Akita M, Ajiki T, Ueno K, Tsugawa D, Tanaka M, Kido M, Toyama H, Fukumoto T
Hepatobiliary Pancreat Dis Int 2020 Apr;19(2):147-152. Epub 2020 Jan 30 doi: 10.1016/j.hbpd.2020.01.002. PMID: 32037277

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Surgical resection of liver metastasis in pancreatic and periampullary carcinoma.
Lopez-Lopez V, Robles-Campos R, López-Conesa A, Brusadin R, Carbonel G, Gomez-Ruiz A, Ruiz JJ, Parrilla P
Minerva Chir 2019 Jun;74(3):253-262. Epub 2019 Jan 2 doi: 10.23736/S0026-4733.18.07972-5. PMID: 30600968
Routine extra-hepatic bile duct resection in gallbladder cancer patients without bile duct infiltration: A systematic review.
Nigri G, Berardi G, Mattana C, Mangogna L, Petrucciani N, Sagnotta A, Aurello P, D'Angelo F, Ramacciato G
Surgeon 2016 Dec;14(6):337-344. Epub 2016 Jul 6 doi: 10.1016/j.surge.2016.06.004. PMID: 27395014
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873

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