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Unresectable Cholangiocarcinoma

MedGen UID:
209022
•Concept ID:
C0862953
•
Neoplastic Process
Synonym: Non-Resectable Cholangiocarcinoma

Definition

Cholangiocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Cholangiocarcinoma

Professional guidelines

PubMed

The multidisciplinary management of cholangiocarcinoma.
Ohaegbulam KC, Koethe Y, Fung A, Mayo SC, Grossberg AJ, Chen EY, Sharzehi K, Kardosh A, Farsad K, Rocha FG, Thomas CR, Nabavizadeh N
Cancer 2023 Jan 15;129(2):184-214. Epub 2022 Nov 16 doi: 10.1002/cncr.34541. PMID: 36382577
Moving the Needle Forward With Locoregional Treatment in Unresectable Cholangiocarcinoma-The Jury Is Still Out.
Scott AJ, Shroff RT
JAMA Oncol 2020 Jan 1;6(1):29-31. doi: 10.1001/jamaoncol.2019.3691. PMID: 31670748
Diagnosis and treatment of cholangiocarcinoma.
Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

Recent clinical studies

Etiology

Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Intrahepatic chemotherapy for unresectable cholangiocarcinoma: review of literature and personal experience.
Massani M, Nistri C, Ruffolo C, Bonariol R, Pauletti B, Bonariol L, Caratozzolo E, Morana G, Bassi N
Updates Surg 2015 Dec;67(4):389-400. doi: 10.1007/s13304-015-0330-3. PMID: 26468142
Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902
Photodynamic therapy for unresectable cholangiocarcinoma.
Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285
Diagnosis and treatment of cholangiocarcinoma.
Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

Diagnosis

Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
Lee HH, Choi MG, Hasan T
Korean J Intern Med 2017 Jan;32(1):1-10. Epub 2017 Jan 1 doi: 10.3904/kjim.2016.200. PMID: 28049283Free PMC Article
Photodynamic therapy for unresectable cholangiocarcinoma.
Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285
Endoscopic palliation of cholangiocarcinoma.
Chahal P, Baron TH
Curr Opin Gastroenterol 2006 Sep;22(5):551-60. doi: 10.1097/01.mog.0000239872.12081.a4. PMID: 16891889
Diagnosis and treatment of cholangiocarcinoma.
Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454
Cholangiocarcinoma.
Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

Therapy

Immune checkpoint inhibitors in cholangiocarcinoma.
Beri N
Immunotherapy 2023 May;15(7):541-551. Epub 2023 Apr 25 doi: 10.2217/imt-2022-0288. PMID: 37096964
Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Locoregional therapy for cholangiocarcinoma.
Kuhlmann JB, Blum HE
Curr Opin Gastroenterol 2013 May;29(3):324-8. doi: 10.1097/MOG.0b013e32835d9dea. PMID: 23337933
Photodynamic therapy for unresectable cholangiocarcinoma.
Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285
Cholangiocarcinoma.
Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191

Prognosis

Immune checkpoint inhibitors in cholangiocarcinoma.
Beri N
Immunotherapy 2023 May;15(7):541-551. Epub 2023 Apr 25 doi: 10.2217/imt-2022-0288. PMID: 37096964
Update on Treatment Options for Advanced Bile Duct Tumours: Radioembolisation for Advanced Cholangiocarcinoma.
Najran P, Lamarca A, Mullan D, McNamara MG, Westwood T, Hubner RA, Lawrence J, Manoharan P, Bell J, Valle JW
Curr Oncol Rep 2017 Jul;19(7):50. doi: 10.1007/s11912-017-0603-8. PMID: 28656502Free PMC Article
Locoregional therapy for cholangiocarcinoma.
Kuhlmann JB, Blum HE
Curr Opin Gastroenterol 2013 May;29(3):324-8. doi: 10.1097/MOG.0b013e32835d9dea. PMID: 23337933
Photodynamic therapy for unresectable cholangiocarcinoma.
Tomizawa Y, Tian J
Dig Dis Sci 2012 Feb;57(2):274-83. Epub 2011 Nov 6 doi: 10.1007/s10620-011-1957-7. PMID: 22057285
Diagnosis and treatment of cholangiocarcinoma.
Boberg KM, Schrumpf E
Curr Gastroenterol Rep 2004 Feb;6(1):52-9. doi: 10.1007/s11894-004-0026-1. PMID: 14720454

Clinical prediction guides

Immune checkpoint inhibitors in cholangiocarcinoma.
Beri N
Immunotherapy 2023 May;15(7):541-551. Epub 2023 Apr 25 doi: 10.2217/imt-2022-0288. PMID: 37096964
Liver transplantation for perihilar cholangiocarcinoma: patient selection and outcomes.
Acher AW, Weber SM, Pawlik TM
Expert Rev Gastroenterol Hepatol 2021 May;15(5):555-566. Epub 2021 Feb 26 doi: 10.1080/17474124.2021.1890584. PMID: 33577361
Clinical Outcomes of Patients With Unresectable Cholangiocarcinoma Treated With Proton Beam Therapy.
Hung SP, Huang BS, Hsieh CE, Lee CH, Tsang NM, Chang JT, Chen JS, Chou WC, Tseng JH, Hong JH
Am J Clin Oncol 2020 Mar;43(3):180-186. doi: 10.1097/COC.0000000000000646. PMID: 31764017
Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis.
Moole H, Tathireddy H, Dharmapuri S, Moole V, Boddireddy R, Yedama P, Dharmapuri S, Uppu A, Bondalapati N, Duvvuri A
World J Gastroenterol 2017 Feb 21;23(7):1278-1288. doi: 10.3748/wjg.v23.i7.1278. PMID: 28275308Free PMC Article
Photodynamic therapy for unresectable cholangiocarcinoma: a comparative effectiveness systematic review and meta-analyses.
Leggett CL, Gorospe EC, Murad MH, Montori VM, Baron TH, Wang KK
Photodiagnosis Photodyn Ther 2012 Sep;9(3):189-95. Epub 2012 Apr 11 doi: 10.1016/j.pdpdt.2012.03.002. PMID: 22959798

Recent systematic reviews

Photodynamic Therapy (PDT), Radiofrequency Ablation (RFA) With Biliary Stents in Palliative Treatment of Unresectable Extrahepatic Cholangiocarcinoma: A Systematic Review and Meta-analysis.
Mohan BP, Chandan S, Khan SR, Kassab LL, Ponnada S, Artifon ELA, Otoch JP, McDonough S, Adler DG
J Clin Gastroenterol 2022 Feb 1;56(2):e153-e160. doi: 10.1097/MCG.0000000000001524. PMID: 33780214
Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis.
Moole H, Tathireddy H, Dharmapuri S, Moole V, Boddireddy R, Yedama P, Dharmapuri S, Uppu A, Bondalapati N, Duvvuri A
World J Gastroenterol 2017 Feb 21;23(7):1278-1288. doi: 10.3748/wjg.v23.i7.1278. PMID: 28275308Free PMC Article
Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902
Photodynamic therapy for unresectable cholangiocarcinoma: a comparative effectiveness systematic review and meta-analyses.
Leggett CL, Gorospe EC, Murad MH, Montori VM, Baron TH, Wang KK
Photodiagnosis Photodyn Ther 2012 Sep;9(3):189-95. Epub 2012 Apr 11 doi: 10.1016/j.pdpdt.2012.03.002. PMID: 22959798
Systematic review: photodynamic therapy for unresectable cholangiocarcinoma.
Gao F, Bai Y, Ma SR, Liu F, Li ZS
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):125-31. Epub 2009 May 20 doi: 10.1007/s00534-009-0109-3. PMID: 19455276

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