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Neurologic Manifestations

MedGen UID:
18017
•Concept ID:
C0027854
•
Finding
Synonyms: Manifestation, Neurologic; Manifestation, Neurological; Manifestations, Neurologic; Manifestations, Neurological; Neurologic Manifestation; Neurologic Signs and Symptoms; Neurological Manifestation; Neurological Manifestations

Definition

Clinical signs and symptoms caused by nervous system injury or dysfunction. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurologic Manifestations

Professional guidelines

PubMed

Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource.
Koch RL, Soler-Alfonso C, Kiely BT, Asai A, Smith AL, Bali DS, Kang PB, Landstrom AP, Akman HO, Burrow TA, Orthmann-Murphy JL, Goldman DS, Pendyal S, El-Gharbawy AH, Austin SL, Case LE, Schiffmann R, Hirano M, Kishnani PS
Mol Genet Metab 2023 Mar;138(3):107525. Epub 2023 Jan 25 doi: 10.1016/j.ymgme.2023.107525. PMID: 36796138
Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.
Sciascia S, Amigo MC, Roccatello D, Khamashta M
Nat Rev Rheumatol 2017 Sep;13(9):548-560. Epub 2017 Aug 3 doi: 10.1038/nrrheum.2017.124. PMID: 28769114
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.
Perry PJ, Wilborn CA
Ann Clin Psychiatry 2012 May;24(2):155-62. PMID: 22563571

Recent clinical studies

Etiology

Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.
Leal Rato M, Bandeira M, Romão VC, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2021 Jun 14;21(8):41. doi: 10.1007/s11910-021-01124-z. PMID: 34125304Free PMC Article
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
Serin HM, Arslan EA
Acta Clin Croat 2019 Jun;58(2):295-302. doi: 10.20471/acc.2019.58.02.13. PMID: 31819326Free PMC Article
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.
Perry PJ, Wilborn CA
Ann Clin Psychiatry 2012 May;24(2):155-62. PMID: 22563571

Diagnosis

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neurologic Manifestations of Rheumatic Diseases.
Goglin SE, Imboden JB
Rheum Dis Clin North Am 2017 Nov;43(4):xiii-xiv. doi: 10.1016/j.rdc.2017.08.001. PMID: 29061250
Neurologic Manifestations of Rheumatic Diseases.
Weisman MH
Rheum Dis Clin North Am 2017 Nov;43(4):xi. doi: 10.1016/j.rdc.2017.08.002. PMID: 29061249
Neurologic Manifestations of Rheumatoid Arthritis.
DeQuattro K, Imboden JB
Rheum Dis Clin North Am 2017 Nov;43(4):561-571. Epub 2017 Aug 31 doi: 10.1016/j.rdc.2017.06.005. PMID: 29061242
Neurologic Manifestations of Primary Sjögren Syndrome.
Margaretten M
Rheum Dis Clin North Am 2017 Nov;43(4):519-529. Epub 2017 Aug 23 doi: 10.1016/j.rdc.2017.06.002. PMID: 29061239

Therapy

Neurologic Manifestations of Gastrointestinal and Nutritional Disorders.
Diesing TS
Continuum (Minneap Minn) 2023 Jun 1;29(3):708-733. doi: 10.1212/CON.0000000000001235. PMID: 37341328
Cervical sympathectomy to treat cerebral vasospasm: a scoping review.
Bombardieri AM, Heifets BD, Treggiari M, Albers GW, Steinberg GK, Heit JJ
Reg Anesth Pain Med 2023 Oct;48(10):513-519. Epub 2022 Nov 24 doi: 10.1136/rapm-2022-103999. PMID: 36424089
Inflammatory Disorders of the Central Nervous System Vessels: Narrative Review.
Ekkert A, Šaulytė M, Jatužis D
Medicina (Kaunas) 2022 Oct 13;58(10) doi: 10.3390/medicina58101446. PMID: 36295606Free PMC Article
Treatment of neuromyelitis optica spectrum disorders.
Romeo AR, Segal BM
Curr Opin Rheumatol 2019 May;31(3):250-255. doi: 10.1097/BOR.0000000000000603. PMID: 30920972
Neurosarcoidosis.
James DG, Sharma OP
Proc R Soc Med 1967 Nov 1;60(11 Part 1):1169-70. PMID: 6060718Free PMC Article

Prognosis

Sarcoidosis.
Cooper D, Suau S
Immunol Allergy Clin North Am 2023 Aug;43(3):583-591. doi: 10.1016/j.iac.2022.10.011. PMID: 37394261
Sarcoidosis.
Cooper D, Suau S
Emerg Med Clin North Am 2022 Feb;40(1):149-157. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.012. PMID: 34782085
Polyarteritis Nodosa Neurologic Manifestations.
de Boysson H, Guillevin L
Neurol Clin 2019 May;37(2):345-357. Epub 2019 Mar 16 doi: 10.1016/j.ncl.2019.01.007. PMID: 30952413
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Sydenham's chorea.
Kulkarni ML, Anees S
Indian Pediatr 1996 Feb;33(2):112-5. PMID: 8772928

Clinical prediction guides

Imaging in Erdheim-Chester Disease.
Aswani Y, Patel A, Zhan X, Ansari S, Marcelino LG, Aswani N, Patel DD, Kandemirli S, Averill S, Bhatt S
Radiographics 2024 Sep;44(9):e240011. doi: 10.1148/rg.240011. PMID: 39172709
Clinical, Radiologic, and Immunologic Features of Patients With CTLA4 Deficiency With Neurologic Involvement.
Coustal C, Goulabchand R, Labauge P, Guilpain P, Carra-Dallière C, Januel E, Jeziorski E, Salle V, Viallard JF, Boutboul D, Fieschi C, Gobert D, Aladjidi N, Rullier P, Graveleau J, Piel-Julian M, Suarez F, Neven B, Mahlaoui N, Ayrignac X
Neurology 2023 Oct 10;101(15):e1560-e1566. Epub 2023 Jul 24 doi: 10.1212/WNL.0000000000207609. PMID: 37487754Free PMC Article
Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557

Recent systematic reviews

Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Unusual neurologic manifestations of Vogt-Koyanagi-Harada disease: a systematic literature review.
Toudou-Daouda M, Ibrahim-Mamadou AK
BMC Neurol 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6. PMID: 35120474Free PMC Article
Frequency of Neurologic Manifestations in COVID-19: A Systematic Review and Meta-analysis.
Misra S, Kolappa K, Prasad M, Radhakrishnan D, Thakur KT, Solomon T, Michael BD, Winkler AS, Beghi E, Guekht A, Pardo CA, Wood GK, Hsiang-Yi Chou S, Fink EL, Schmutzhard E, Kheradmand A, Hoo FK, Kumar A, Das A, Srivastava AK, Agarwal A, Dua T, Prasad K
Neurology 2021 Dec 7;97(23):e2269-e2281. Epub 2021 Oct 11 doi: 10.1212/WNL.0000000000012930. PMID: 34635561Free PMC Article
Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Collantes MEV, Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG
Can J Neurol Sci 2021 Jan;48(1):66-76. Epub 2020 Jul 15 doi: 10.1017/cjn.2020.146. PMID: 32665054Free PMC Article
Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.
Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053

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