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Catalepsy

MedGen UID:
40134
•Concept ID:
C0007370
•
Mental or Behavioral Dysfunction
Synonyms: Anochlesia; Anochlesias; Catalepsies

Definition

A nervous system disorder characterized by diminished responsiveness and consciousness, and rigidity of the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCatalepsy

Professional guidelines

PubMed

Tetrahydrobiopterin (BH(4)) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock-in mouse model.
Jung-Kc K, Tristán-Noguero A, Altankhuyag A, Piñol Belenguer D, Prestegård KS, Fernandez-Carasa I, Colini Baldeschi A, Sigatulina Bondarenko M, García-Cazorla A, Consiglio A, Martinez A
J Inherit Metab Dis 2024 May;47(3):494-508. Epub 2024 Jan 9 doi: 10.1002/jimd.12702. PMID: 38196161
Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease.
Sadeghian Z, Eyvari-Brooshghalan S, Sabahi M, Nourouzi N, Haddadi R
Neurosci Lett 2022 Nov 1;790:136884. Epub 2022 Sep 23 doi: 10.1016/j.neulet.2022.136884. PMID: 36162540
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia.
Wang Y, He Y, Yang F, Abame MA, Wu C, Peng Y, Feng L, Shen J, Wang Z, He L
J Pharmacol Exp Ther 2021 Jul;378(1):20-30. Epub 2021 May 11 doi: 10.1124/jpet.120.000414. PMID: 33975897

Recent clinical studies

Etiology

8-Substituted 2-alkynyl-N(9)-propargyladenines as A2A adenosine receptor antagonists.
Endo K, Deguchi K, Matsunaga H, Tomaya K, Yamada K
Bioorg Med Chem 2014 Jun 15;22(12):3072-82. Epub 2014 Apr 28 doi: 10.1016/j.bmc.2014.04.041. PMID: 24815000
The role of deprivation, abuse, and trauma in pediatric catatonia without a clear medical cause.
Dhossche DM, Ross CA, Stoppelbein L
Acta Psychiatr Scand 2012 Jan;125(1):25-32. Epub 2011 Oct 24 doi: 10.1111/j.1600-0447.2011.01779.x. PMID: 22017207
Catatonia: a review.
Weder ND, Muralee S, Penland H, Tampi RR
Ann Clin Psychiatry 2008 Apr-Jun;20(2):97-107. doi: 10.1080/10401230802017092. PMID: 18568581
Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism.
Salamone JD, Betz AJ, Ishiwari K, Felsted J, Madson L, Mirante B, Clark K, Font L, Korbey S, Sager TN, Hockemeyer J, Muller CE
Front Biosci 2008 May 1;13:3594-605. doi: 10.2741/2952. PMID: 18508458
Clozapine.
Jann MW
Pharmacotherapy 1991;11(3):179-95. PMID: 1677765

Diagnosis

Catatonia and epilepsy: An underappreciated relationship.
Rogers JP, Shorvon S, Luccarelli J
Epilepsy Behav 2024 Oct;159:109983. Epub 2024 Aug 24 doi: 10.1016/j.yebeh.2024.109983. PMID: 39182262
Misdiagnosis of narcolepsy.
Dunne L, Patel P, Maschauer EL, Morrison I, Riha RL
Sleep Breath 2016 Dec;20(4):1277-1284. Epub 2016 Jun 23 doi: 10.1007/s11325-016-1365-5. PMID: 27339629Free PMC Article
Movement disorders in catatonia.
Wijemanne S, Jankovic J
J Neurol Neurosurg Psychiatry 2015 Aug;86(8):825-32. Epub 2014 Nov 19 doi: 10.1136/jnnp-2014-309098. PMID: 25411548
Narcolepsy in childhood.
Nevsimalova S
Sleep Med Rev 2009 Apr;13(2):169-80. Epub 2009 Jan 18 doi: 10.1016/j.smrv.2008.04.007. PMID: 19153053
Catatonia: a review.
Weder ND, Muralee S, Penland H, Tampi RR
Ann Clin Psychiatry 2008 Apr-Jun;20(2):97-107. doi: 10.1080/10401230802017092. PMID: 18568581

Therapy

Movement disorders in catatonia.
Wijemanne S, Jankovic J
J Neurol Neurosurg Psychiatry 2015 Aug;86(8):825-32. Epub 2014 Nov 19 doi: 10.1136/jnnp-2014-309098. PMID: 25411548
Safety and side effects of cannabidiol, a Cannabis sativa constituent.
Bergamaschi MM, Queiroz RH, Zuardi AW, Crippa JA
Curr Drug Saf 2011 Sep 1;6(4):237-49. doi: 10.2174/157488611798280924. PMID: 22129319
Catatonia: a review.
Weder ND, Muralee S, Penland H, Tampi RR
Ann Clin Psychiatry 2008 Apr-Jun;20(2):97-107. doi: 10.1080/10401230802017092. PMID: 18568581
The gamma-hydroxybutyrate withdrawal syndrome.
Tarabar AF, Nelson LS
Toxicol Rev 2004;23(1):45-9. doi: 10.2165/00139709-200423010-00005. PMID: 15298492
Clozapine.
Jann MW
Pharmacotherapy 1991;11(3):179-95. PMID: 1677765

Prognosis

In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent.
Boyina HK, Geethakhrishnan SL, Panuganti S, Gangarapu K, Devarakonda KP, Bakshi V, Guggilla SR
Adv Exp Med Biol 2020;1195:1-11. doi: 10.1007/978-3-030-32633-3_1. PMID: 32468451
In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.
Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL
PLoS One 2016;11(3):e0150602. Epub 2016 Mar 10 doi: 10.1371/journal.pone.0150602. PMID: 26963248Free PMC Article
Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.
Wiley JL, Marusich JA, Huffman JW
Life Sci 2014 Feb 27;97(1):55-63. Epub 2013 Sep 23 doi: 10.1016/j.lfs.2013.09.011. PMID: 24071522Free PMC Article
Preclinical behavioral models for predicting antipsychotic activity.
Castagné V, Moser PC, Porsolt RD
Adv Pharmacol 2009;57:381-418. Epub 2009 Nov 27 doi: 10.1016/S1054-3589(08)57010-4. PMID: 20230767
Progressive catatonia.
Brasić JR, Zagzag D, Kowalik S, Prichep L, John ER, Liang HG, Klutchko B, Cancro R, Sheitman BB, Buchsbaum M, Brathwaite C
Psychol Rep 1999 Feb;84(1):239-46. doi: 10.2466/pr0.1999.84.1.239. PMID: 10203957

Clinical prediction guides

Gaps and Controversies in Catatonia as a Movement Disorder.
Lenka A, Perera VM, Espay AJ, Pontone GM, Okun MS
Mov Disord 2024 Oct;39(10):1716-1728. Epub 2024 Jun 26 doi: 10.1002/mds.29906. PMID: 38924566
Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons.
Arai M, Suzuki E, Kitamura S, Otaki M, Kanai K, Yamasaki M, Watanabe M, Kambe Y, Murata K, Takada Y, Arisawa T, Kobayashi K, Tajika R, Miyazaki T, Yamaguchi M, Lazarus M, Hayashi Y, Itohara S, de Kerchove d'Exaerde A, Nawa H, Kim R, Bito H, Momiyama T, Masukawa D, Goshima Y
J Neurosci 2024 Mar 13;44(11) doi: 10.1523/JNEUROSCI.1504-23.2024. PMID: 38286627Free PMC Article
Comparative neuropharmacology of structurally distinct non-fentanyl opioids that are appearing on recreational drug markets worldwide.
Vandeputte MM, Tsai MM, Chen L, Glatfelter GC, Walther D, Stove CP, Shi L, Baumann MH
Drug Alcohol Depend 2023 Aug 1;249:109939. Epub 2023 May 23 doi: 10.1016/j.drugalcdep.2023.109939. PMID: 37276825Free PMC Article
In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent.
Boyina HK, Geethakhrishnan SL, Panuganti S, Gangarapu K, Devarakonda KP, Bakshi V, Guggilla SR
Adv Exp Med Biol 2020;1195:1-11. doi: 10.1007/978-3-030-32633-3_1. PMID: 32468451
In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.
Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL
PLoS One 2016;11(3):e0150602. Epub 2016 Mar 10 doi: 10.1371/journal.pone.0150602. PMID: 26963248Free PMC Article

Recent systematic reviews

Catatonia associated with epileptic seizures: A systematic review of case reports.
Silva Gadelho L, Gama Marques J
Epilepsy Res 2022 Oct;186:107016. Epub 2022 Sep 6 doi: 10.1016/j.eplepsyres.2022.107016. PMID: 36116265
Catatonia in N-methyl-d-aspartate receptor antibody encephalitis: Phenomenological characteristics from a systematic review of case reports.
Serra-Mestres J, Villagrasa-Blasco B, Thacker V, Jaimes-Albornoz W, Sharma P, Isetta M
Gen Hosp Psychiatry 2020 May-Jun;64:9-16. Epub 2020 Jan 28 doi: 10.1016/j.genhosppsych.2020.01.002. PMID: 32070914

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