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Hypnic headache

MedGen UID:
156012
•Concept ID:
C0752150
•
Disease or Syndrome
Synonyms: Alarm Clock Headache; Alarm Clock Headaches; Clock Headache, Alarm; Clock Headaches, Alarm; Headache Syndrome, Hypnic; Headache Syndromes, Hypnic; Headache, Alarm Clock; Headache, Hypnic; Headaches, Alarm Clock; Hypnic Headache; Hypnic Headache Syndrome; Hypnic Headache Syndromes
SNOMED CT: Hypnic headache (122711000119109); Hypnic headache (associated with sleep) (122711000119109)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0012459
Monarch Initiative: MONDO:0017181
Orphanet: ORPHA276429

Definition

A headache disorder that occurs exclusively at night, waking the affected individual from sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypnic headache
Follow this link to review classifications for Hypnic headache in Orphanet.

Professional guidelines

PubMed

Sleep disorders and chronic craniofacial pain: Characteristics and management possibilities.
Almoznino G, Benoliel R, Sharav Y, Haviv Y
Sleep Med Rev 2017 Jun;33:39-50. Epub 2016 May 11 doi: 10.1016/j.smrv.2016.04.005. PMID: 27321865
The Role of Melatonin in the Treatment of Primary Headache Disorders.
Gelfand AA, Goadsby PJ
Headache 2016 Sep;56(8):1257-66. Epub 2016 Jun 17 doi: 10.1111/head.12862. PMID: 27316772Free PMC Article
Hypnic headache: clinical features, pathophysiology, and treatment.
Evers S, Goadsby PJ
Neurology 2003 Mar 25;60(6):905-9. doi: 10.1212/01.wnl.0000046582.21771.9c. PMID: 12654950

Curated

UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

Recent clinical studies

Etiology

Headaches of the elderly.
Bravo TP
Curr Neurol Neurosci Rep 2015 Jun;15(6):30. doi: 10.1007/s11910-015-0552-2. PMID: 25893722
Indomethacin-responsive headaches.
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407
Hypnic headache.
Lanteri-Minet M, Donnet A
Curr Pain Headache Rep 2010 Aug;14(4):309-15. doi: 10.1007/s11916-010-0124-8. PMID: 20512536
Other primary headaches.
Pascual J
Neurol Clin 2009 May;27(2):557-71. doi: 10.1016/j.ncl.2009.01.005. PMID: 19289232
Indomethacin-responsive headache syndromes.
Dodick DW
Curr Pain Headache Rep 2004 Feb;8(1):19-26. doi: 10.1007/s11916-004-0036-6. PMID: 14731379

Diagnosis

Hypnic Headache - What do we know in 2022?
Lindner D, Scheffler A, Nsaka M, Holle-Lee D
Cephalalgia 2023 Mar;43(3):3331024221148659. doi: 10.1177/03331024221148659. PMID: 36786376
Headache in the elderly.
Kaniecki RG, Levin AD
Handb Clin Neurol 2019;167:511-528. doi: 10.1016/B978-0-12-804766-8.00028-5. PMID: 31753152
Indomethacin-responsive headaches.
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407
Hypnic headache.
Lanteri-Minet M
Headache 2014 Oct;54(9):1556-9. Epub 2014 Sep 18 doi: 10.1111/head.12447. PMID: 25231430
Hypnic headache.
Holle D, Naegel S, Obermann M
Cephalalgia 2013 Dec;33(16):1349-57. Epub 2013 Jul 5 doi: 10.1177/0333102413495967. PMID: 23832130

Therapy

Epidemiology and clinical features of hypnic headache: A systematic review and meta-analysis.
Melchior AG, Ayyoub A, Christensen RH, Al-Khazali HM, Amin FM, Ashina H
Cephalalgia 2023 Dec;43(12):3331024231218389. doi: 10.1177/03331024231218389. PMID: 38051816
Caffeine for Headaches: Helpful or Harmful? A Brief Review of the Literature.
Zduńska A, Cegielska J, Zduński S, Domitrz I
Nutrients 2023 Jul 17;15(14) doi: 10.3390/nu15143170. PMID: 37513588Free PMC Article
Indomethacin-responsive headaches.
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407
Hypnic headache and caffeine.
Holle D, Obermann M
Expert Rev Neurother 2012 Sep;12(9):1125-32. doi: 10.1586/ern.12.100. PMID: 23039391
Hypnic headache.
Obermann M, Holle D
Expert Rev Neurother 2010 Sep;10(9):1391-7. doi: 10.1586/ern.10.112. PMID: 20839413

Prognosis

Hypnic headache: a review of clinical features, therapeutic options and outcomes.
Liang JF, Wang SJ
Cephalalgia 2014 Sep;34(10):795-805. Epub 2014 Jun 18 doi: 10.1177/0333102414537914. PMID: 24942086
Interictal pain in primary headache syndromes.
Marmura MJ, Young WB
Curr Pain Headache Rep 2012 Apr;16(2):170-4. doi: 10.1007/s11916-012-0243-5. PMID: 22249655
Hypnic headache.
Manni R, Ghiotto N
Handb Clin Neurol 2010;97:469-72. doi: 10.1016/S0072-9752(10)97041-3. PMID: 20816447
Focus on therapy of hypnic headache.
Lisotto C, Rossi P, Tassorelli C, Ferrante E, Nappi G
J Headache Pain 2010 Aug;11(4):349-54. Epub 2010 Jun 29 doi: 10.1007/s10194-010-0227-y. PMID: 20585827Free PMC Article
Hypnic headache: clinical features, pathophysiology, and treatment.
Evers S, Goadsby PJ
Neurology 2003 Mar 25;60(6):905-9. doi: 10.1212/01.wnl.0000046582.21771.9c. PMID: 12654950

Clinical prediction guides

Epidemiology and clinical features of hypnic headache: A systematic review and meta-analysis.
Melchior AG, Ayyoub A, Christensen RH, Al-Khazali HM, Amin FM, Ashina H
Cephalalgia 2023 Dec;43(12):3331024231218389. doi: 10.1177/03331024231218389. PMID: 38051816
Sleep disorder-related headaches.
Ferini-Strambi L, Galbiati A, Combi R
Neurol Sci 2019 May;40(Suppl 1):107-113. doi: 10.1007/s10072-019-03837-z. PMID: 30906963
Hypnic headache: a review of clinical features, therapeutic options and outcomes.
Liang JF, Wang SJ
Cephalalgia 2014 Sep;34(10):795-805. Epub 2014 Jun 18 doi: 10.1177/0333102414537914. PMID: 24942086
Headache and sleep.
Alberti A
Sleep Med Rev 2006 Dec;10(6):431-7. Epub 2006 Jul 26 doi: 10.1016/j.smrv.2006.03.003. PMID: 16872851
Hypnic headache: an update.
De Simone R, Marano E, Ranieri A, Bonavita V
Neurol Sci 2006 May;27 Suppl 2:S144-8. doi: 10.1007/s10072-006-0590-2. PMID: 16688619

Recent systematic reviews

Epidemiology and clinical features of hypnic headache: A systematic review and meta-analysis.
Melchior AG, Ayyoub A, Christensen RH, Al-Khazali HM, Amin FM, Ashina H
Cephalalgia 2023 Dec;43(12):3331024231218389. doi: 10.1177/03331024231218389. PMID: 38051816
Beyond chronic migraine: a systematic review and expert opinion on the off-label use of botulinum neurotoxin type-A in other primary headache disorders.
Argyriou AA, Mitsikostas DD, Mantovani E, Vikelis M, Tamburin S
Expert Rev Neurother 2021 Aug;21(8):923-944. Epub 2021 Aug 18 doi: 10.1080/14737175.2021.1958677. PMID: 34289791

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
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