U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hemicrania continua

MedGen UID:
748511
Concept ID:
C2349425
Disease or Syndrome
Synonyms: Hemicrania Continua; hemicrania continua
SNOMED CT: Hemicrania continua (443095000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018615
Orphanet: ORPHA443070

Definition

A rare trigeminal autonomic cephalalgia characterized by indomethacin-sensitive, persistent, strictly unilateral headache lasting for more than three months, associated with ipsilateral conjunctival injection, lacrimation, nasal congestion, rhinorrhea, forehead and facial sweating, miosis, ptosis, eyelid edema, and/or restlessness or agitation, and not better accounted for by another type of headache. Migrainous symptoms such as photophobia are often observed. The headache may be continuous (unremitting subtype) or interrupted by remission periods of more than 24 hours (remitting subtype). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemicrania continua

Professional guidelines

PubMed

Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Lake AE 3rd, Saper JR
Neurology 2002 Sep 10;59(5 Suppl 2):S8-13. doi: 10.1212/wnl.59.5_suppl_2.s8. PMID: 12221150

Recent clinical studies

Etiology

Burish MJ, Rozen TD
Neurol Clin 2019 Nov;37(4):847-869. Epub 2019 Aug 24 doi: 10.1016/j.ncl.2019.07.001. PMID: 31563236
Barloese MCJ
Clin Auton Res 2018 Jun;28(3):315-324. Epub 2017 Sep 23 doi: 10.1007/s10286-017-0468-9. PMID: 28942483
Lai TH, Wang SJ
Curr Pain Headache Rep 2016 Jan;20(1):5. doi: 10.1007/s11916-015-0531-y. PMID: 26707496
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407
Silberstein SD
Headache 1994 Sep;34(8):S2-7. doi: 10.1111/j.1526-4610.1994.hed3408s2.x. PMID: 7960725

Diagnosis

Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Paliwal VK, Uniyal R
Neurol India 2021 Mar-Apr;69(Supplement):S135-S143. doi: 10.4103/0028-3886.315982. PMID: 34003159
Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Vgontzas A, Rizzoli PB
Med Clin North Am 2019 Mar;103(2):235-250. Epub 2018 Dec 20 doi: 10.1016/j.mcna.2018.10.007. PMID: 30704679
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407

Therapy

Goadsby PJ
Continuum (Minneap Minn) 2024 Apr 1;30(2):488-497. doi: 10.1212/CON.0000000000001409. PMID: 38568495
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Burish MJ, Rozen TD
Neurol Clin 2019 Nov;37(4):847-869. Epub 2019 Aug 24 doi: 10.1016/j.ncl.2019.07.001. PMID: 31563236
VanderPluym J
Curr Neurol Neurosci Rep 2015;15(2):516. doi: 10.1007/s11910-014-0516-y. PMID: 25467407
Silberstein SD
Headache 1994 Sep;34(8):S2-7. doi: 10.1111/j.1526-4610.1994.hed3408s2.x. PMID: 7960725

Prognosis

Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Barloese MCJ
Clin Auton Res 2018 Jun;28(3):315-324. Epub 2017 Sep 23 doi: 10.1007/s10286-017-0468-9. PMID: 28942483
Costa A, Antonaci F, Ramusino MC, Nappi G
Curr Neuropharmacol 2015;13(3):304-23. doi: 10.2174/1570159x13666150309233556. PMID: 26411963Free PMC Article
Tobin J, Flitman S
Headache 2009 Nov-Dec;49(10):1521-33. Epub 2009 Aug 6 doi: 10.1111/j.1526-4610.2009.01493.x. PMID: 19674126
Nappi G, Perrotta A, Rossi P, Sandrini G
Expert Rev Neurother 2008 Mar;8(3):361-84. doi: 10.1586/14737175.8.3.361. PMID: 18345968

Clinical prediction guides

Bahra A
Cephalalgia 2023 Nov;43(11):3331024231214239. doi: 10.1177/03331024231214239. PMID: 37950675
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Costa A, Antonaci F, Ramusino MC, Nappi G
Curr Neuropharmacol 2015;13(3):304-23. doi: 10.2174/1570159x13666150309233556. PMID: 26411963Free PMC Article
Tobin J, Flitman S
Headache 2009 Nov-Dec;49(10):1521-33. Epub 2009 Aug 6 doi: 10.1111/j.1526-4610.2009.01493.x. PMID: 19674126
Jasper JF, Hayek SM
Pain Physician 2008 Mar-Apr;11(2):187-200. PMID: 18354711

Recent systematic reviews

Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, Amin FM, Ashina H
Cephalalgia 2023 Jan;43(1):3331024221131343. doi: 10.1177/03331024221131343. PMID: 36588185
Ghosh A, Silva E, Burish MJ
Cephalalgia 2021 Nov;41(13):1382-1395. Epub 2021 Aug 18 doi: 10.1177/03331024211027560. PMID: 34407646
Viana M, Tassorelli C, Allena M, Nappi G, Sjaastad O, Antonaci F
J Headache Pain 2013 Feb 18;14(1):14. doi: 10.1186/1129-2377-14-14. PMID: 23565739Free PMC Article
Moura LM, Bezerra JM, Fleming NR
Rev Bras Anestesiol 2012 Mar-Apr;62(2):173-87. doi: 10.1016/S0034-7094(12)70116-2. PMID: 22440373
Jasper JF, Hayek SM
Pain Physician 2008 Mar-Apr;11(2):187-200. PMID: 18354711

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...