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Focal non-motor seizure

MedGen UID:
1716722
•Concept ID:
C5397690
•
Disease or Syndrome
Synonyms: Focal seizure without motor onset; Partial seizure without motor onset
 
HPO: HP:0032679

Definition

A type of focal-onset seizure characterized by non-motor signs or symptoms (or behavior arrest) as its initial semiological manifestation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal non-motor seizure

Professional guidelines

PubMed

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610
Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures.
Caraballo RH, Reyes Valenzuela G, Fortini S, Espeche A, Gamboni B, Silva W, Semprino M, Fasulo L, Chacón S, Gallo A, Galicchio S, Cachia P
Epilepsy Behav 2023 Jun;143:109245. Epub 2023 May 12 doi: 10.1016/j.yebeh.2023.109245. PMID: 37182500
Reponse of second-line treatment in focal status epilepticus: A tertiary hospital experience.
Llauradó A, Campos D, Quintana M, Ballvé A, Fonseca E, Abraira L, Giffreu A, Toledo M, Santamarina E
Epilepsy Res 2022 Sep;185:106988. Epub 2022 Jul 19 doi: 10.1016/j.eplepsyres.2022.106988. PMID: 35907324

Recent clinical studies

Etiology

The spectrum of epilepsy in children with 15q13.3 microdeletion syndrome.
Whitney R, Nair A, McCready E, Keller AE, Adil IS, Aziz AS, Borys O, Siu K, Shah C, Meaney BF, Jones K, RamachandranNair R
Seizure 2021 Nov;92:221-229. Epub 2021 Sep 26 doi: 10.1016/j.seizure.2021.09.016. PMID: 34601452
Electroclinical markers to differentiate between focal and generalized epilepsies.
Raga S, Rheims S, Specchio N, Wilmshurst JM
Epileptic Disord 2021 Jun 1;23(3):437-458. doi: 10.1684/epd.2021.1291. PMID: 34106053
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601
Acute seizure epidemiology in a neurological emergency department.
Valdes-Galvan RE, Gonzalez-Calderon G, Castro-Martinez E
Rev Neurol 2019 Apr 16;68(8):321-325. doi: 10.33588/rn.6808.2018218. PMID: 30963528
Age-dependent semiology of frontal lobe seizures.
Hintz M, Krenz V, Schulze-Bonhage A
Epilepsy Res 2019 Jan;149:83-87. Epub 2018 Oct 23 doi: 10.1016/j.eplepsyres.2018.10.007. PMID: 30529718

Diagnosis

Clinical characterization of non-ketotic hyperglycemia-related seizures: A systematic review and individual participant data meta-analysis.
Licchetta L, Ferri L, Morsillo F, Faustini-Fustini M, Toni F, Pondrelli F, Nonino F, Bisulli F, Tinuper P
Seizure 2023 Mar;106:50-57. Epub 2023 Jan 27 doi: 10.1016/j.seizure.2023.01.018. PMID: 36773573
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.
Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601
Neonatal seizures: When semiology points to etiology.
Santarone ME, Pietrafusa N, Fusco L
Seizure 2020 Aug;80:161-165. Epub 2020 Jun 18 doi: 10.1016/j.seizure.2020.06.025. PMID: 32585613
Electroencephalography in neonatal epilepsies.
Okumura A
Pediatr Int 2020 Sep;62(9):1019-1028. doi: 10.1111/ped.14227. PMID: 32153072
The new classification of seizures: an overview for the general physician.
Liyanagedera S, Williams RP
J R Coll Physicians Edinb 2017 Dec;47(4):336-338. doi: 10.4997/JRCPE.2017.406. PMID: 29537403

Therapy

Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures.
Caraballo RH, Reyes Valenzuela G, Fortini S, Espeche A, Gamboni B, Silva W, Semprino M, Fasulo L, Chacón S, Gallo A, Galicchio S, Cachia P
Epilepsy Behav 2023 Jun;143:109245. Epub 2023 May 12 doi: 10.1016/j.yebeh.2023.109245. PMID: 37182500
Use of sulthiame as add-on therapy in children with non-self-limited focal epilepsies of childhood.
Caraballo R, Reyes G, Semprino M, Chacón S, Galichio S, Adi J, Gallo A, Gamboni B, Cachia P, Fortini S, Espeche A
Epilepsy Behav 2023 Jun;143:109220. Epub 2023 Apr 27 doi: 10.1016/j.yebeh.2023.109220. PMID: 37119578
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Reponse of second-line treatment in focal status epilepticus: A tertiary hospital experience.
Llauradó A, Campos D, Quintana M, Ballvé A, Fonseca E, Abraira L, Giffreu A, Toledo M, Santamarina E
Epilepsy Res 2022 Sep;185:106988. Epub 2022 Jul 19 doi: 10.1016/j.eplepsyres.2022.106988. PMID: 35907324
Acute seizure epidemiology in a neurological emergency department.
Valdes-Galvan RE, Gonzalez-Calderon G, Castro-Martinez E
Rev Neurol 2019 Apr 16;68(8):321-325. doi: 10.33588/rn.6808.2018218. PMID: 30963528

Prognosis

Does response to vagus nerve stimulation for drug-resistant epilepsy differ in patients with and without Lennox-Gastaut syndrome?
Dibué M, Greco T, Spoor JKH, Senft C, Kamp MA
Brain Behav 2023 Aug;13(8):e3025. Epub 2023 Jun 29 doi: 10.1002/brb3.3025. PMID: 37386739Free PMC Article
Seizure semiology and predictors of outcomes in Chinese patients with glutamic acid decarboxylase antibody-associated neurological syndrome.
Lin N, Bai L, Liu Q, Chen J, Ren H, Guan H, Lu Q
BMC Neurol 2023 Apr 11;23(1):149. doi: 10.1186/s12883-023-03182-x. PMID: 37041500Free PMC Article
Photosensitive occipital lobe epilepsy: Delineation of an under-recognized reflex epilepsy syndrome according to the new ILAE criteria and long-term follow-up.
Cerrahoğlu Şirin T, Yılmaz T, Elmalı AD, Bebek N, Demirbilek V, Baykan B
Epileptic Disord 2023 Apr;25(2):187-199. Epub 2023 May 10 doi: 10.1002/epd2.20011. PMID: 36992562
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
The UK experience of stereoelectroencephalography in children: An analysis of factors predicting the identification of a seizure-onset zone and subsequent seizure freedom.
UK Children’s Epilepsy Surgery Collaboration
Epilepsia 2021 Aug;62(8):1883-1896. Epub 2021 Jun 24 doi: 10.1111/epi.16954. PMID: 34165813

Clinical prediction guides

Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures.
Caraballo RH, Reyes Valenzuela G, Fortini S, Espeche A, Gamboni B, Silva W, Semprino M, Fasulo L, Chacón S, Gallo A, Galicchio S, Cachia P
Epilepsy Behav 2023 Jun;143:109245. Epub 2023 May 12 doi: 10.1016/j.yebeh.2023.109245. PMID: 37182500
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
The spectrum of epilepsy in children with 15q13.3 microdeletion syndrome.
Whitney R, Nair A, McCready E, Keller AE, Adil IS, Aziz AS, Borys O, Siu K, Shah C, Meaney BF, Jones K, RamachandranNair R
Seizure 2021 Nov;92:221-229. Epub 2021 Sep 26 doi: 10.1016/j.seizure.2021.09.016. PMID: 34601452
Neonatal seizures: When semiology points to etiology.
Santarone ME, Pietrafusa N, Fusco L
Seizure 2020 Aug;80:161-165. Epub 2020 Jun 18 doi: 10.1016/j.seizure.2020.06.025. PMID: 32585613
Age-dependent semiology of frontal lobe seizures.
Hintz M, Krenz V, Schulze-Bonhage A
Epilepsy Res 2019 Jan;149:83-87. Epub 2018 Oct 23 doi: 10.1016/j.eplepsyres.2018.10.007. PMID: 30529718

Recent systematic reviews

Clinical characterization of non-ketotic hyperglycemia-related seizures: A systematic review and individual participant data meta-analysis.
Licchetta L, Ferri L, Morsillo F, Faustini-Fustini M, Toni F, Pondrelli F, Nonino F, Bisulli F, Tinuper P
Seizure 2023 Mar;106:50-57. Epub 2023 Jan 27 doi: 10.1016/j.seizure.2023.01.018. PMID: 36773573

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