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Cluster headache

MedGen UID:
3503
Concept ID:
C0009088
Disease or Syndrome
Synonym: Cluster headache syndrome
SNOMED CT: Cluster headache (193031009); Cluster headache syndrome (193031009); Migrainous neuralgia (193031009); Horton's headache (193031009); Vasomotor headache (193031009); Histamine cephalgia (193031009); Neuralgic migraine (193031009); Histamine headache (193031009); Horton's neuralgia (193031009); Ciliary neuralgia (193947008); Chronic cluster headache (230473009)
 
HPO: HP:0012199
Monarch Initiative: MONDO:0043537

Definition

A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs. [from HPO]

Term Hierarchy

Conditions with this feature

Cluster headache, familial
MedGen UID:
350040
Concept ID:
C1861513
Disease or Syndrome
The Headache Classification Committee of the International Headache Society (1988) listed the following criteria for cluster headache (CH): at least 5 attacks of severe unilateral orbital, supraorbital, and/or temporal pain, lasting 15 to 180 minutes, associated with at least 1 of 8 local autonomic signs, and occurring once every other day to 8 per day. Approximately 85% of CH patients have the episodic subtype, in which the headaches occur in cluster periods lasting from 7 days to 1 year and separated by attack-free intervals of 1 month or more. The remainder of patients have the chronic subtype, in which attacks recur for greater than 1 year without remission or with remissions lasting less than 1 month (Lipton et al., 2004).

Professional guidelines

PubMed

Diener HC, May A
Drugs 2022 Jan;82(1):33-42. Epub 2021 Dec 17 doi: 10.1007/s40265-021-01658-z. PMID: 34919214Free PMC Article
Mier RW, Dhadwal S
Dent Clin North Am 2018 Oct;62(4):611-628. Epub 2018 Aug 14 doi: 10.1016/j.cden.2018.06.006. PMID: 30189986
Hoffmann J, May A
Lancet Neurol 2018 Jan;17(1):75-83. Epub 2017 Nov 23 doi: 10.1016/S1474-4422(17)30405-2. PMID: 29174963

Curated

UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

Recent clinical studies

Etiology

Burish M
Continuum (Minneap Minn) 2024 Apr 1;30(2):391-410. doi: 10.1212/CON.0000000000001411. PMID: 38568490
Diener HC, May A
Drugs 2022 Jan;82(1):33-42. Epub 2021 Dec 17 doi: 10.1007/s40265-021-01658-z. PMID: 34919214Free PMC Article
Leone M, Ferraro S, Proietti Cecchini A
Handb Clin Neurol 2021;182:401-414. doi: 10.1016/B978-0-12-819973-2.00027-7. PMID: 34266608
Cheema S, Matharu M
Neurol India 2021 Mar-Apr;69(Supplement):S124-S134. doi: 10.4103/0028-3886.315983. PMID: 34003158
Dueland AN
Headache 2015 Jul-Aug;55(7):1045-9. Epub 2015 Jun 29 doi: 10.1111/head.12621. PMID: 26121267

Diagnosis

Schindler EAD, Burish MJ
BMJ 2022 Mar 16;376:e059577. doi: 10.1136/bmj-2020-059577. PMID: 35296510
Cheema S, Matharu M
Neurol India 2021 Mar-Apr;69(Supplement):S124-S134. doi: 10.4103/0028-3886.315983. PMID: 34003158
Suri H, Ailani J
Curr Neurol Neurosci Rep 2021 May 5;21(7):31. doi: 10.1007/s11910-021-01114-1. PMID: 33948734
May A, Schwedt TJ, Magis D, Pozo-Rosich P, Evers S, Wang SJ
Nat Rev Dis Primers 2018 Mar 1;4:18006. doi: 10.1038/nrdp.2018.6. PMID: 29493566
Hoffmann J, May A
Lancet Neurol 2018 Jan;17(1):75-83. Epub 2017 Nov 23 doi: 10.1016/S1474-4422(17)30405-2. PMID: 29174963

Therapy

Peng KP, Burish MJ
Cephalalgia 2023 Aug;43(8):3331024231196808. doi: 10.1177/03331024231196808. PMID: 37652457
May A, Evers S, Goadsby PJ, Leone M, Manzoni GC, Pascual J, Carvalho V, Romoli M, Aleksovska K, Pozo-Rosich P, Jensen RH; European Academy of Neurology Task Force
Eur J Neurol 2023 Oct;30(10):2955-2979. Epub 2023 Jul 28 doi: 10.1111/ene.15956. PMID: 37515405
Schindler EAD, Burish MJ
BMJ 2022 Mar 16;376:e059577. doi: 10.1136/bmj-2020-059577. PMID: 35296510
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Millstine D, Chen CY, Bauer B
BMJ 2017 May 16;357:j1805. doi: 10.1136/bmj.j1805. PMID: 28512119

Prognosis

Alabbad S, Figueredo N, Yuan H, Silberstein S
Expert Rev Neurother 2024 May;24(5):477-485. Epub 2024 Apr 1 doi: 10.1080/14737175.2024.2332754. PMID: 38557226
Kim SA, Choi SY, Youn MS, Pozo-Rosich P, Lee MJ
Cephalalgia 2023 Sep;43(9):3331024231201577. doi: 10.1177/03331024231201577. PMID: 37728577
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775
Leroux E, Ducros A
Orphanet J Rare Dis 2008 Jul 23;3:20. doi: 10.1186/1750-1172-3-20. PMID: 18651939Free PMC Article
Láinez MJ, Monzón MJ
Curr Neurol Neurosci Rep 2001 Mar;1(2):118-24. doi: 10.1007/s11910-001-0006-x. PMID: 11898507

Clinical prediction guides

Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Børte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O'Connor E, Bjornsdottir G, Häppölä P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgård FJ, Heinze K, Lund N, Thomas LF, Hsu CL, Pirinen M, Hautakangas H, Ribasés M, Guerzoni S, Sivakumar P, Yip J, Heinze A, Küçükali F, Ostrowski SR, Pedersen OB, Kristoffersen ES, Martinsen AE, Artigas MS, Lagrata S, Cainazzo MM, Adebimpe J, Quinn O, Göbel C, Cirkel A, Volk AE, Heilmann-Heimbach S, Skogholt AH, Gabrielsen ME, Wilbrink LA, Danno D, Mehta D, Guðbjartsson DF; HUNT All-In Headache, The International Headache Genetics Consortium, DBDS Genomic Consortium, Rosendaal FR, Willems van Dijk K, Fronczek R, Wagner M, Scherer M, Göbel H, Sleegers K, Sveinsson OA, Pani L, Zoli M, Ramos-Quiroga JA, Dardiotis E, Steinberg A, Riedel-Heller S, Sjöstrand C, Thorgeirsson TE, Stefansson H, Southgate L, Trembath RC, Vandrovcova J, Noordam R, Paemeleire K, Stefansson K, Fann CS, Waldenlind E, Tronvik E, Jensen RH, Chen SP, Houlden H, Terwindt GM, Kubisch C, Maestrini E, Vikelis M, Pozo-Rosich P, Belin AC, Matharu M, van den Maagdenberg AMJM, Hansen TF, Ramirez A, Zwart JA; International Consortium for Cluster Headache Genetics
Ann Neurol 2023 Oct;94(4):713-726. Epub 2023 Aug 7 doi: 10.1002/ana.26743. PMID: 37486023Free PMC Article
Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Terrier LM, Hadjikhani N, Destrieux C
J Neurol 2022 Jul;269(7):3443-3460. Epub 2022 Mar 6 doi: 10.1007/s00415-022-11002-4. PMID: 35249132
Giamberardino MA, Affaitati G, Costantini R, Guglielmetti M, Martelletti P
Intern Emerg Med 2020 Jan;15(1):109-117. Epub 2020 Jan 1 doi: 10.1007/s11739-019-02266-2. PMID: 31893348
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775

Recent systematic reviews

Musubire AK, Cheema S, Ray JC, Hutton EJ, Matharu M
J Headache Pain 2023 Apr 4;24(1):36. doi: 10.1186/s10194-023-01572-7. PMID: 37016284Free PMC Article
Membrilla JA, Roa J, Díaz-de-Terán J
J Neurol 2023 Feb;270(2):689-710. Epub 2022 Oct 31 doi: 10.1007/s00415-022-11436-w. PMID: 36310189
Xu J, Sun Z, Wu J, Rana M, Garza J, Zhu AC, Chakravarthy KV, Abd-Elsayed A, Rosenquist E, Basi H, Christo P, Cheng J
Pain Physician 2021 Mar;24(2):E131-E152. PMID: 33740342Free PMC Article
Robbins MS, Starling AJ, Pringsheim TM, Becker WJ, Schwedt TJ
Headache 2016 Jul;56(7):1093-106. doi: 10.1111/head.12866. PMID: 27432623
Matharu M
BMJ Clin Evid 2010 Feb 9;2010 PMID: 21718584Free PMC Article

Supplemental Content

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    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

    Consumer resources

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