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Episodic pain

MedGen UID:
814998
•Concept ID:
C3808668
•
Sign or Symptom
Synonym: Pain, episodic
 
HPO: HP:0032148

Definition

Intermittent pain, i.e., pain that occurs occasionally and at irregular intervals. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpisodic pain

Conditions with this feature

Familial episodic pain syndrome with predominantly upper body involvement
MedGen UID:
814997
•Concept ID:
C3808667
•
Disease or Syndrome
Familial episodic pain syndrome-1 is an autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress (summary by Kremeyer et al., 2010). Genetic Heterogeneity of Familial Episodic Pain Syndrome See also FEPS2 (615551), caused by mutation in the SCN10A gene (604427) on chromosome 3p22, and FEPS3 (615552), caused by mutation in the SCN11A gene (604385) on chromosome 3p22.
See: Condition Record
Familial episodic pain syndrome with predominantly upper body involvement

Professional guidelines

PubMed

Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.
Noguchi A, Tezuka T, Okuda H, Kobayashi H, Harada KH, Yoshida T, Akioka S, Wada K, Takeya A, Kabata-Murasawa R, Kondo D, Ishikawa K, Asano T, Fujiwara M, Hishikawa N, Mizukami T, Hitomi T, Youssefian S, Nagai Y, Tanaka M, Eto K, Shiraishi H, Amaya F, Koizumi A, Takahashi T
Int J Mol Sci 2024 Jun 21;25(13) doi: 10.3390/ijms25136832. PMID: 38999942Free PMC Article
Surgical Treatment of Trigeminal Neuralgia.
Bick SKB, Eskandar EN
Neurosurg Clin N Am 2017 Jul;28(3):429-438. Epub 2017 Mar 24 doi: 10.1016/j.nec.2017.02.009. PMID: 28600016
Cancer pain management: newer perspectives on opioids and episodic pain.
Coluzzi PH
Am J Hosp Palliat Care 1998 Jan-Feb;15(1):13-22. doi: 10.1177/104990919801500105. PMID: 9468974

Recent clinical studies

Etiology

Achenbach syndrome (paroxysmal finger hematoma).
Godoy A, Tabares AH
Vasc Med 2019 Aug;24(4):361-366. Epub 2019 Jun 4 doi: 10.1177/1358863X19849627. PMID: 31159682
Medial Gamma Knife thalamotomy for intractable pain.
Urgosik D, Liscak R
J Neurosurg 2018 Dec 1;129(Suppl1):72-76. doi: 10.3171/2018.7.GKS181583. PMID: 30544296
Painful and painless channelopathies.
Bennett DL, Woods CG
Lancet Neurol 2014 Jun;13(6):587-99. Epub 2014 May 6 doi: 10.1016/S1474-4422(14)70024-9. PMID: 24813307
Buerger's disease.
Dargon PT, Landry GJ
Ann Vasc Surg 2012 Aug;26(6):871-80. Epub 2012 Jan 27 doi: 10.1016/j.avsg.2011.11.005. PMID: 22284771
Preventive treatment of migraine.
Silberstein SD
Trends Pharmacol Sci 2006 Aug;27(8):410-5. Epub 2006 Jul 3 doi: 10.1016/j.tips.2006.06.003. PMID: 16820222

Diagnosis

Atypical painful stroke presentations: A review.
Bayat M, Bayat A, Blauenfeldt RA
Acta Neurol Scand 2022 Nov;146(5):465-474. Epub 2022 Jul 5 doi: 10.1111/ane.13666. PMID: 35788546Free PMC Article
Achenbach syndrome (paroxysmal finger hematoma).
Godoy A, Tabares AH
Vasc Med 2019 Aug;24(4):361-366. Epub 2019 Jun 4 doi: 10.1177/1358863X19849627. PMID: 31159682
Review of primary and secondary erythromelalgia.
Mann N, King T, Murphy R
Clin Exp Dermatol 2019 Jul;44(5):477-482. Epub 2019 Jan 4 doi: 10.1111/ced.13891. PMID: 30609105
Painful and painless channelopathies.
Bennett DL, Woods CG
Lancet Neurol 2014 Jun;13(6):587-99. Epub 2014 May 6 doi: 10.1016/S1474-4422(14)70024-9. PMID: 24813307
Buerger's disease.
Dargon PT, Landry GJ
Ann Vasc Surg 2012 Aug;26(6):871-80. Epub 2012 Jan 27 doi: 10.1016/j.avsg.2011.11.005. PMID: 22284771

Therapy

Breakthrough cancer pain in 2020.
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Review of primary and secondary erythromelalgia.
Mann N, King T, Murphy R
Clin Exp Dermatol 2019 Jul;44(5):477-482. Epub 2019 Jan 4 doi: 10.1111/ced.13891. PMID: 30609105
Surgical Treatment of Trigeminal Neuralgia.
Bick SKB, Eskandar EN
Neurosurg Clin N Am 2017 Jul;28(3):429-438. Epub 2017 Mar 24 doi: 10.1016/j.nec.2017.02.009. PMID: 28600016
Dentine hypersensitivity.
West N, Seong J, Davies M
Monogr Oral Sci 2014;25:108-22. Epub 2014 Jun 26 doi: 10.1159/000360749. PMID: 24993261
Buerger's disease.
Dargon PT, Landry GJ
Ann Vasc Surg 2012 Aug;26(6):871-80. Epub 2012 Jan 27 doi: 10.1016/j.avsg.2011.11.005. PMID: 22284771

Prognosis

Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children With Acute Recurrent or Chronic Pancreatitis.
Uc A, Cress GA, Wang F, Abu-El-Haija M, Ellery KM, Fishman DS, Gariepy CE, Gonska T, Lin TK, Liu QY, Mehta M, Maqbool A, McFerron BA, Morinville VD, Ooi CY, Perito ER, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle DM, Wilschanski M, Zheng Y, Yuan Y, Lowe ME; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
J Pediatr Gastroenterol Nutr 2022 Nov 1;75(5):643-649. Epub 2022 Aug 17 doi: 10.1097/MPG.0000000000003590. PMID: 35976273Free PMC Article
The clinical course of neck pain: Are trajectory patterns stable over a 1-year period?
Irgens P, Myhrvold BL, Kongsted A, Waagan K, Engebretsen KB, Vøllestad NK, Robinson HS
Eur J Pain 2022 Feb;26(2):531-542. Epub 2021 Nov 3 doi: 10.1002/ejp.1879. PMID: 34699124
Breakthrough cancer pain in 2020.
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Achenbach syndrome (paroxysmal finger hematoma).
Godoy A, Tabares AH
Vasc Med 2019 Aug;24(4):361-366. Epub 2019 Jun 4 doi: 10.1177/1358863X19849627. PMID: 31159682
Fabry disease: cardiac manifestations and therapeutic options.
Pierre-Louis B, Kumar A, Frishman WH
Cardiol Rev 2009 Jan-Feb;17(1):31-5. doi: 10.1097/CRD.0b013e31818adc50. PMID: 19092368

Clinical prediction guides

Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children With Acute Recurrent or Chronic Pancreatitis.
Uc A, Cress GA, Wang F, Abu-El-Haija M, Ellery KM, Fishman DS, Gariepy CE, Gonska T, Lin TK, Liu QY, Mehta M, Maqbool A, McFerron BA, Morinville VD, Ooi CY, Perito ER, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle DM, Wilschanski M, Zheng Y, Yuan Y, Lowe ME; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer
J Pediatr Gastroenterol Nutr 2022 Nov 1;75(5):643-649. Epub 2022 Aug 17 doi: 10.1097/MPG.0000000000003590. PMID: 35976273Free PMC Article
The clinical course of neck pain: Are trajectory patterns stable over a 1-year period?
Irgens P, Myhrvold BL, Kongsted A, Waagan K, Engebretsen KB, Vøllestad NK, Robinson HS
Eur J Pain 2022 Feb;26(2):531-542. Epub 2021 Nov 3 doi: 10.1002/ejp.1879. PMID: 34699124
Breakthrough cancer pain in 2020.
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Achenbach syndrome (paroxysmal finger hematoma).
Godoy A, Tabares AH
Vasc Med 2019 Aug;24(4):361-366. Epub 2019 Jun 4 doi: 10.1177/1358863X19849627. PMID: 31159682
From "Breakthrough" to "Episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations.
Løhre ET, Klepstad P, Bennett MI, Brunelli C, Caraceni A, Fainsinger RL, Knudsen AK, Mercadante S, Sjøgren P, Kaasa S; European Association for Palliative Care Research Network
J Pain Symptom Manage 2016 Jun;51(6):1013-9. Epub 2016 Feb 26 doi: 10.1016/j.jpainsymman.2015.12.329. PMID: 26921493

Recent systematic reviews

From "Breakthrough" to "Episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations.
Løhre ET, Klepstad P, Bennett MI, Brunelli C, Caraceni A, Fainsinger RL, Knudsen AK, Mercadante S, Sjøgren P, Kaasa S; European Association for Palliative Care Research Network
J Pain Symptom Manage 2016 Jun;51(6):1013-9. Epub 2016 Feb 26 doi: 10.1016/j.jpainsymman.2015.12.329. PMID: 26921493
Opioids for the management of breakthrough (episodic) pain in cancer patients.
Zeppetella G, Ribeiro MD
Cochrane Database Syst Rev 2006 Jan 25;(1):CD004311. doi: 10.1002/14651858.CD004311.pub2. PMID: 16437482

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