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Toothache

MedGen UID:
11857
•Concept ID:
C0040460
•
Sign or Symptom
Synonyms: Odontalgia; Odontalgias; Toothaches
SNOMED CT: Pain in tooth (27355003); Toothache (27355003); Dentagra (27355003); Dentalgia (27355003); Odontalgia (27355003)

Definition

A painful sensation originating from a tooth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToothache

Professional guidelines

PubMed

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania.
Carrasco-Labra A, Polk DE, Urquhart O, Aghaloo T, Claytor JW Jr, Dhar V, Dionne RA, Espinoza L, Gordon SM, Hersh EV, Law AS, Li BS, Schwartz PJ, Suda KJ, Turturro MA, Wright ML, Dawson T, Miroshnychenko A, Pahlke S, Pilcher L, Shirey M, Tampi M, Moore PA
J Am Dent Assoc 2023 Sep;154(9):814-825.e2. doi: 10.1016/j.adaj.2023.06.014. PMID: 37634915Free PMC Article
THE VOICE OF THE PATIENT IN OROFACIAL PAIN MANAGEMENT.
Häggman-Henrikson B, Lobbezoo F, Durham J, Peck C, List T
J Evid Based Dent Pract 2022 Jan;22(1S):101648. Epub 2021 Oct 29 doi: 10.1016/j.jebdp.2021.101648. PMID: 35063175
Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.
Barbagallo M, Sacerdote P
Minerva Pediatr 2019 Feb;71(1):82-99. doi: 10.23736/S0026-4946.18.05453-1. PMID: 30574736

Recent clinical studies

Etiology

Cannabidiol as an Alternative Analgesic for Acute Dental Pain.
Chrepa V, Villasenor S, Mauney A, Kotsakis G, Macpherson L
J Dent Res 2024 Mar;103(3):235-242. Epub 2023 Nov 1 doi: 10.1177/00220345231200814. PMID: 37910667Free PMC Article
Prevalence of toothache and associated factors in children and adolescents: a systematic review and meta-analysis.
Santos PS, Barasuol JC, Moccelini BS, Magno MB, Bolan M, Martins-Junior PA, Maia LC, Cardoso M
Clin Oral Investig 2022 Feb;26(2):1105-1119. Epub 2021 Nov 18 doi: 10.1007/s00784-021-04255-2. PMID: 34791550
Orbital AL amyloid.
Chan TM, Prospero Ponce CM, Allen RC, Bell D, Lee AG
Orbit 2020 Feb;39(1):68-70. Epub 2019 Apr 25 doi: 10.1080/01676830.2019.1594980. PMID: 31020884
Systematic review and recommendations for nonodontogenic toothache.
Yatani H, Komiyama O, Matsuka Y, Wajima K, Muraoka W, Ikawa M, Sakamoto E, De Laat A, Heir GM
J Oral Rehabil 2014 Nov;41(11):843-52. Epub 2014 Jul 10 doi: 10.1111/joor.12208. PMID: 25040436
Pain and flare-up after endodontic treatment procedures.
Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057

Diagnosis

Tooth-Related Pain or Not?
Renton T
Headache 2020 Jan;60(1):235-246. Epub 2019 Nov 1 doi: 10.1111/head.13689. PMID: 31675112
Atypical odontalgia--an update.
Patel SB, Boros AL, Kumar SK
J Calif Dent Assoc 2012 Sep;40(9):739-47. PMID: 23097829
Endo-perio lesions: diagnosis and clinical considerations.
Shenoy N, Shenoy A
Indian J Dent Res 2010 Oct-Dec;21(4):579-85. doi: 10.4103/0970-9290.74238. PMID: 21187629
Barodontalgia.
Zadik Y
J Endod 2009 Apr;35(4):481-5. Epub 2009 Feb 26 doi: 10.1016/j.joen.2008.12.004. PMID: 19345791
Pulpal pain diagnosis--a review.
Bender IB
J Endod 2000 Mar;26(3):175-9. doi: 10.1097/00004770-200003000-00012. PMID: 11199715

Therapy

Cannabidiol as an Alternative Analgesic for Acute Dental Pain.
Chrepa V, Villasenor S, Mauney A, Kotsakis G, Macpherson L
J Dent Res 2024 Mar;103(3):235-242. Epub 2023 Nov 1 doi: 10.1177/00220345231200814. PMID: 37910667Free PMC Article
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968Free PMC Article
Atraumatic restorative treatment versus conventional restorative treatment for managing dental caries.
Dorri M, Martinez-Zapata MJ, Walsh T, Marinho VC, Sheiham Deceased A, Zaror C
Cochrane Database Syst Rev 2017 Dec 28;12(12):CD008072. doi: 10.1002/14651858.CD008072.pub2. PMID: 29284075Free PMC Article
Barodontalgia.
Zadik Y
J Endod 2009 Apr;35(4):481-5. Epub 2009 Feb 26 doi: 10.1016/j.joen.2008.12.004. PMID: 19345791
Atypical odontalgia.
Graff-Radford SB, Solberg WK
J Craniomandib Disord 1992 Fall;6(4):260-5. PMID: 1298761

Prognosis

The pharmacological management of dental pain.
Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G
Expert Opin Pharmacother 2020 Apr;21(5):591-601. Epub 2020 Feb 6 doi: 10.1080/14656566.2020.1718651. PMID: 32027199
Tooth-Related Pain or Not?
Renton T
Headache 2020 Jan;60(1):235-246. Epub 2019 Nov 1 doi: 10.1111/head.13689. PMID: 31675112
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.
Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626
Nonodontogenic toothache.
Okeson JP
Tex Dent J 2000 Jul;117(7):64-74. PMID: 11858065
Nonodontogenic toothache.
Okeson JP, Falace DA
Dent Clin North Am 1997 Apr;41(2):367-83. PMID: 9142490

Clinical prediction guides

The pharmacological management of dental pain.
Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G
Expert Opin Pharmacother 2020 Apr;21(5):591-601. Epub 2020 Feb 6 doi: 10.1080/14656566.2020.1718651. PMID: 32027199
Dental anxiety and influencing factors: A cross-sectional questionnaire-based survey.
Jeddy N, Nithya S, Radhika T, Jeddy N
Indian J Dent Res 2018 Jan-Feb;29(1):10-15. doi: 10.4103/ijdr.IJDR_33_17. PMID: 29442080
A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe).
Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS
Food Funct 2013 Jun;4(6):845-55. Epub 2013 Apr 24 doi: 10.1039/c3fo30337c. PMID: 23612703
The oral health assessment tool--validity and reliability.
Chalmers JM, King PL, Spencer AJ, Wright FA, Carter KD
Aust Dent J 2005 Sep;50(3):191-9. doi: 10.1111/j.1834-7819.2005.tb00360.x. PMID: 16238218
Nonodontogenic toothache.
Okeson JP
Tex Dent J 2000 Jul;117(7):64-74. PMID: 11858065

Recent systematic reviews

Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania.
Carrasco-Labra A, Polk DE, Urquhart O, Aghaloo T, Claytor JW Jr, Dhar V, Dionne RA, Espinoza L, Gordon SM, Hersh EV, Law AS, Li BS, Schwartz PJ, Suda KJ, Turturro MA, Wright ML, Dawson T, Miroshnychenko A, Pahlke S, Pilcher L, Shirey M, Tampi M, Moore PA
J Am Dent Assoc 2023 Sep;154(9):814-825.e2. doi: 10.1016/j.adaj.2023.06.014. PMID: 37634915Free PMC Article
Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association.
Lockhart PB, Tampi MP, Abt E, Aminoshariae A, Durkin MJ, Fouad AF, Gopal P, Hatten BW, Kennedy E, Lang MS, Patton LL, Paumier T, Suda KJ, Pilcher L, Urquhart O, O'Brien KK, Carrasco-Labra A
J Am Dent Assoc 2019 Nov;150(11):906-921.e12. doi: 10.1016/j.adaj.2019.08.020. PMID: 31668170Free PMC Article
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968Free PMC Article
Effectiveness of oral health education on oral hygiene and dental caries in schoolchildren: Systematic review and meta-analysis.
Stein C, Santos NML, Hilgert JB, Hugo FN
Community Dent Oral Epidemiol 2018 Feb;46(1):30-37. Epub 2017 Aug 16 doi: 10.1111/cdoe.12325. PMID: 28815661
Atraumatic restorative treatment versus conventional restorative treatment for managing dental caries.
Dorri M, Martinez-Zapata MJ, Walsh T, Marinho VC, Sheiham Deceased A, Zaror C
Cochrane Database Syst Rev 2017 Dec 28;12(12):CD008072. doi: 10.1002/14651858.CD008072.pub2. PMID: 29284075Free PMC Article

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    Practice guidelines

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