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Transitional cell carcinoma

MedGen UID:
2875
•Concept ID:
C0007138
•
Neoplastic Process
Synonyms: Carcinoma, Transitional Cell; Carcinomas, Transitional Cell; Cell Carcinoma, Transitional; Cell Carcinomas, Transitional; Transitional Cell Carcinoma; Transitional Cell Carcinomas
SNOMED CT: TCC - Transitional cell carcinoma (27090000); Transitional cell carcinoma (27090000); Transitional carcinoma (27090000); Urothelial carcinoma (27090000)
 
Monarch Initiative: MONDO:0006474

Definition

A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitional cell carcinoma

Professional guidelines

PubMed

Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer.
Helal C, Pobel C, Bayle A, Vasseur D, Nicotra C, Blanc-Durand F, Naoun N, Bernard-Tessier A, Patrikidou A, Colomba E, Flippot R, Fuerea A, Auger N, Ngo Camus M, Besse B, Lacroix L, Rouleau E, Ponce S, Italiano A, Loriot Y
Eur J Cancer 2023 Dec;195:113368. Epub 2023 Oct 6 doi: 10.1016/j.ejca.2023.113368. PMID: 37897866
ACR Appropriateness Criteria® Post-Treatment Surveillance of Bladder Cancer.
Expert Panel on Urologic Imaging, Allen BC, Oto A, Akin O, Alexander LF, Chong J, Froemming AT, Fulgham PF, Lloyd S, Maranchie JK, Mody RN, Patel BN, Schieda N, Turkbey IB, Vapiwala N, Venkatesan AM, Wang CL, Yoo DC, Lockhart ME
J Am Coll Radiol 2019 Nov;16(11S):S417-S427. doi: 10.1016/j.jacr.2019.05.026. PMID: 31685109
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG
J Clin Oncol 2001 Feb 1;19(3):666-75. doi: 10.1200/JCO.2001.19.3.666. PMID: 11157016

Recent clinical studies

Etiology

Association Between Human Papillomavirus and Transitional Cell Carcinoma of the Bladder.
Abdollahzadeh P, Madani SH, Khazaei S, Sajadimajd S, Izadi B, Najafi F
Urol J 2017 Nov 4;14(6):5047-5050. doi: 10.22037/uj.v14i6.3748. PMID: 29101759
Management of transitional-cell carcinoma of the renal pelvis and ureter.
Ozsahin M, Ugurluer G, Zouhair A
Swiss Med Wkly 2009 Jun 27;139(25-26):353-6. doi: 10.4414/smw.2009.12676. PMID: 19562529
Canine transitional cell carcinoma.
Mutsaers AJ, Widmer WR, Knapp DW
J Vet Intern Med 2003 Mar-Apr;17(2):136-44. doi: 10.1892/0891-6640(2003)017<0136:ctcc>2.3.co;2. PMID: 12683611
Indications for urethrectomy.
Elmajian DA
Semin Urol Oncol 2001 Feb;19(1):37-44. PMID: 11246732
Familial transitional cell carcinoma.
Kiemeney LA, Schoenberg M
J Urol 1996 Sep;156(3):867-72. PMID: 8709350

Diagnosis

Association Between Human Papillomavirus and Transitional Cell Carcinoma of the Bladder.
Abdollahzadeh P, Madani SH, Khazaei S, Sajadimajd S, Izadi B, Najafi F
Urol J 2017 Nov 4;14(6):5047-5050. doi: 10.22037/uj.v14i6.3748. PMID: 29101759
Imaging and staging of transitional cell carcinoma: part 2, upper urinary tract.
Vikram R, Sandler CM, Ng CS
AJR Am J Roentgenol 2009 Jun;192(6):1488-93. doi: 10.2214/AJR.09.2577. PMID: 19457809
Imaging and staging of transitional cell carcinoma: part 1, lower urinary tract.
Vikram R, Sandler CM, Ng CS
AJR Am J Roentgenol 2009 Jun;192(6):1481-7. doi: 10.2214/AJR.08.1318. PMID: 19457808
Canine transitional cell carcinoma.
Mutsaers AJ, Widmer WR, Knapp DW
J Vet Intern Med 2003 Mar-Apr;17(2):136-44. doi: 10.1892/0891-6640(2003)017<0136:ctcc>2.3.co;2. PMID: 12683611
Transitional cell carcinoma of the pelvicalices and ureter.
Leder RA, Dunnick NR
AJR Am J Roentgenol 1990 Oct;155(4):713-22. doi: 10.2214/ajr.155.4.2119098. PMID: 2119098

Therapy

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Perioperative pembrolizumab therapy in muscle-invasive bladder cancer: Phase III KEYNOTE-866 and KEYNOTE-905/EV-303.
Galsky MD, Hoimes CJ, Necchi A, Shore N, Witjes JA, Steinberg G, Bedke J, Nishiyama H, Fang X, Kataria R, Sbar E, Jia X, Siefker-Radtke A
Future Oncol 2021 Aug;17(24):3137-3150. Epub 2021 May 19 doi: 10.2217/fon-2021-0273. PMID: 34008425
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
The biology and rationale of targeting nectin-4 in urothelial carcinoma.
Heath EI, Rosenberg JE
Nat Rev Urol 2021 Feb;18(2):93-103. Epub 2020 Nov 25 doi: 10.1038/s41585-020-00394-5. PMID: 33239713
Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?
Sylvester RJ, Oosterlinck W, Holmang S, Sydes MR, Birtle A, Gudjonsson S, De Nunzio C, Okamura K, Kaasinen E, Solsona E, Ali-El-Dein B, Tatar CA, Inman BA, N'Dow J, Oddens JR, Babjuk M
Eur Urol 2016 Feb;69(2):231-44. Epub 2015 Jun 16 doi: 10.1016/j.eururo.2015.05.050. PMID: 26091833

Prognosis

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial.
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD
Lancet Oncol 2017 Mar;18(3):312-322. Epub 2017 Jan 26 doi: 10.1016/S1470-2045(17)30065-7. PMID: 28131785
Urological tumors in renal transplantation.
Tillou X, Doerfler A
Minerva Urol Nefrol 2014 Mar;66(1):57-67. PMID: 24721941
Laparoscopic radical cystectomy.
Puppo P, Naselli A
Curr Urol Rep 2005 Mar;6(2):106-8. doi: 10.1007/s11934-005-0076-4. PMID: 15717966
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG
J Clin Oncol 2001 Feb 1;19(3):666-75. doi: 10.1200/JCO.2001.19.3.666. PMID: 11157016
Transitional cell carcinoma of the bladder in the pediatric patient.
Hoenig DM, McRae S, Chen SC, Diamond DA, Rabinowitz R, Caldamone AA
J Urol 1996 Jul;156(1):203-5. PMID: 8648805

Clinical prediction guides

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.
Feng H, Deng Z, Huang Y, Liu Z, Ruan Y, Wang T, Liu J
Front Immunol 2023;14:1219209. Epub 2023 Aug 17 doi: 10.3389/fimmu.2023.1219209. PMID: 37662947Free PMC Article
Crosstalk between autophagy and bladder transitional cell carcinoma by autophagy-related lncRNAs.
Feng J, Wang M, Du GS, Peng K, Li LQ, Li XS
Medicine (Baltimore) 2023 Jun 30;102(26):e34130. doi: 10.1097/MD.0000000000034130. PMID: 37390250Free PMC Article
Diagnostic Advances in Urine Cytology.
Xing J, Reynolds JP
Surg Pathol Clin 2018 Sep;11(3):601-610. Epub 2018 Jul 13 doi: 10.1016/j.path.2018.06.001. PMID: 30190143
The Emerging Molecular Landscape of Urothelial Carcinoma.
Solomon JP, Hansel DE
Surg Pathol Clin 2016 Sep;9(3):391-404. doi: 10.1016/j.path.2016.04.004. PMID: 27523968
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153

Recent systematic reviews

The Anti-Nectin 4: A Promising Tumor Cells Target. A Systematic Review.
Bouleftour W, Guillot A, Magne N
Mol Cancer Ther 2022 Apr 1;21(4):493-501. doi: 10.1158/1535-7163.MCT-21-0846. PMID: 35131876
Urothelial Carcinoma and Prostate-specific Membrane Antigen: Cellular, Imaging, and Prognostic Implications.
Tariq A, McCart Reed AE, Morton A, Porten S, Vela I, Williams ED, Yaxley JW, Black PC, Roberts MJ
Eur Urol Focus 2022 Sep;8(5):1256-1269. Epub 2021 Aug 21 doi: 10.1016/j.euf.2021.07.016. PMID: 34429271
Systemic therapies for metastatic hormone-sensitive prostate cancer: network meta-analysis.
Mori K, Mostafaei H, Sari Motlagh R, Pradere B, Quhal F, Laukhtina E, Schuettfort VM, Kramer G, Abufaraj M, Karakiewicz PI, Kimura T, Egawa S, Shariat SF
BJU Int 2022 Apr;129(4):423-433. Epub 2021 Jul 21 doi: 10.1111/bju.15507. PMID: 34171173Free PMC Article
Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?
Sylvester RJ, Oosterlinck W, Holmang S, Sydes MR, Birtle A, Gudjonsson S, De Nunzio C, Okamura K, Kaasinen E, Solsona E, Ali-El-Dein B, Tatar CA, Inman BA, N'Dow J, Oddens JR, Babjuk M
Eur Urol 2016 Feb;69(2):231-44. Epub 2015 Jun 16 doi: 10.1016/j.eururo.2015.05.050. PMID: 26091833

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