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Advanced Transitional Cell Carcinoma

MedGen UID:
1731178
•Concept ID:
C5419451
•
Neoplastic Process

Definition

Transitional cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Vinflunine for the treatment of non-small cell lung cancer.
Genova C, Alama A, Coco S, Rijavec E, Dal Bello MG, Vanni I, Biello F, Barletta G, Rossi G, Grossi F
Expert Opin Investig Drugs 2016 Dec;25(12):1447-1455. Epub 2016 Nov 1 doi: 10.1080/13543784.2016.1252331. PMID: 27771969
New agents for treatment of advanced transitional cell carcinoma.
Perabo FG, Müller SC
Ann Oncol 2007 May;18(5):835-43. Epub 2006 Oct 3 doi: 10.1093/annonc/mdl331. PMID: 17018703
Second-line treatment of advanced transitional cell carcinoma of the urothelial tract.
Sternberg CN
Curr Opin Urol 2001 Sep;11(5):523-9. doi: 10.1097/00042307-200109000-00012. PMID: 11493775

Recent clinical studies

Etiology

Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834
Systemic therapy for unresectable and metastatic transitional cell carcinoma of the urothelium: first-line and beyond.
Cheng T
Curr Opin Support Palliat Care 2008 Sep;2(3):153-60. doi: 10.1097/SPC.0b013e328309c72c. PMID: 18685414
Seven year update of an EORTC phase III trial of high-dose intensity M-VAC chemotherapy and G-CSF versus classic M-VAC in advanced urothelial tract tumours.
Sternberg CN, de Mulder P, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, Witjes JA, Spina M, van Groeningen CJ, Duclos B, Roberts JT, de Balincourt C, Collette L; EORTC Genito-Urinary Cancer Group
Eur J Cancer 2006 Jan;42(1):50-4. Epub 2005 Dec 5 doi: 10.1016/j.ejca.2005.08.032. PMID: 16330205
Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924.
Sternberg CN, de Mulder PH, Schornagel JH, Théodore C, Fossa SD, van Oosterom AT, Witjes F, Spina M, van Groeningen CJ, de Balincourt C, Collette L; European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group
J Clin Oncol 2001 May 15;19(10):2638-46. doi: 10.1200/JCO.2001.19.10.2638. PMID: 11352955
Chemotherapy of urothelial tract tumors.
Yagoda A
Cancer 1987 Aug 1;60(3 Suppl):574-85. doi: 10.1002/1097-0142(19870801)60:3+<574::aid-cncr2820601524>3.0.co;2-c. PMID: 3297286

Diagnosis

Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium.
Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD, Vogelzang NJ
Lancet Oncol 2010 Sep;11(9):861-70. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70086-3. PMID: 20537950
Gemcitabine in the treatment of advanced transitional cell carcinoma of the urothelium.
Bellmunt J, Albiol S, de Olano AR, Pujadas J, Maroto P; Spanish Oncology Genitourinary Group (SOGUG)
Ann Oncol 2006 May;17 Suppl 5:v113-7. doi: 10.1093/annonc/mdj964. PMID: 16807437
Gemcitabine and carboplatin in advanced transitional cell carcinoma of the urinary tract: an alternative therapy.
Nogué-Aliguer M, Carles J, Arrivi A, Juan O, Alonso L, Font A, Mellado B, Garrido P, Sáenz A; Spanish Cooperative Group
Cancer 2003 May 1;97(9):2180-6. doi: 10.1002/cncr.10990. PMID: 12712469
Platinum-based chemotherapy for advanced transitional cell carcinoma of the upper urinary tract.
Lerner SE, Blute ML, Richardson RL, Zincke H
Mayo Clin Proc 1996 Oct;71(10):945-50. PMID: 8820768
Meningeal carcinomatosis from transitional cell carcinoma of the bladder.
Eng C, Cunningham D, Quade BJ, Schwamm L, Kantoff PW, Skarin AT
Cancer 1993 Jul 15;72(2):553-7. doi: 10.1002/1097-0142(19930715)72:2<553::aid-cncr2820720236>3.0.co;2-z. PMID: 8319186

Therapy

Tailored Immunotherapy Approach With Nivolumab in Advanced Transitional Cell Carcinoma.
Grimm MO, Schmitz-Dräger BJ, Zimmermann U, Grün CB, Baretton GB, Schmitz M, Foller S, Leucht K, Schostak M, Zengerling F, Schumacher U, Loidl W, Meran J
J Clin Oncol 2022 Jul 1;40(19):2128-2137. Epub 2022 Mar 11 doi: 10.1200/JCO.21.02631. PMID: 35275706
Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834
Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium.
Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD, Vogelzang NJ
Lancet Oncol 2010 Sep;11(9):861-70. Epub 2010 May 25 doi: 10.1016/S1470-2045(10)70086-3. PMID: 20537950
Seven year update of an EORTC phase III trial of high-dose intensity M-VAC chemotherapy and G-CSF versus classic M-VAC in advanced urothelial tract tumours.
Sternberg CN, de Mulder P, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, Witjes JA, Spina M, van Groeningen CJ, Duclos B, Roberts JT, de Balincourt C, Collette L; EORTC Genito-Urinary Cancer Group
Eur J Cancer 2006 Jan;42(1):50-4. Epub 2005 Dec 5 doi: 10.1016/j.ejca.2005.08.032. PMID: 16330205
Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924.
Sternberg CN, de Mulder PH, Schornagel JH, Théodore C, Fossa SD, van Oosterom AT, Witjes F, Spina M, van Groeningen CJ, de Balincourt C, Collette L; European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group
J Clin Oncol 2001 May 15;19(10):2638-46. doi: 10.1200/JCO.2001.19.10.2638. PMID: 11352955

Prognosis

Management of advanced bladder cancer in patients with impaired renal function.
Bournakis E, Dimopoulos MA, Bamias A
Expert Rev Anticancer Ther 2011 Jun;11(6):931-9. doi: 10.1586/era.10.197. PMID: 21707290
Vinflunine: a fluorinated vinca alkaloid for bladder cancer therapy.
Gerullis H
Drugs Today (Barc) 2011 Jan;47(1):17-25. doi: 10.1358/dot.2011.47.1.1576693. PMID: 21373647
Vinflunine.
Frampton JE, Moen MD
Drugs 2010 Jul 9;70(10):1283-93. doi: 10.2165/11204970-000000000-00000. PMID: 20568834
Seven year update of an EORTC phase III trial of high-dose intensity M-VAC chemotherapy and G-CSF versus classic M-VAC in advanced urothelial tract tumours.
Sternberg CN, de Mulder P, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, Witjes JA, Spina M, van Groeningen CJ, Duclos B, Roberts JT, de Balincourt C, Collette L; EORTC Genito-Urinary Cancer Group
Eur J Cancer 2006 Jan;42(1):50-4. Epub 2005 Dec 5 doi: 10.1016/j.ejca.2005.08.032. PMID: 16330205
Second-line treatment of advanced transitional cell carcinoma of the urothelial tract.
Sternberg CN
Curr Opin Urol 2001 Sep;11(5):523-9. doi: 10.1097/00042307-200109000-00012. PMID: 11493775

Clinical prediction guides

Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Vinflunine: drug safety evaluation of this novel synthetic vinca alkaloid.
Schutz FA, Bellmunt J, Rosenberg JE, Choueiri TK
Expert Opin Drug Saf 2011 Jul;10(4):645-53. Epub 2011 Apr 28 doi: 10.1517/14740338.2011.581660. PMID: 21524237
Gemcitabine in the treatment of advanced transitional cell carcinoma of the urothelium.
Bellmunt J, Albiol S, de Olano AR, Pujadas J, Maroto P; Spanish Oncology Genitourinary Group (SOGUG)
Ann Oncol 2006 May;17 Suppl 5:v113-7. doi: 10.1093/annonc/mdj964. PMID: 16807437
FOLFOX-4 in pre-treated patients with advanced transitional cell carcinoma of the bladder.
Di Lorenzo G, Autorino R, Giordano A, Giuliano M, D'Armiento M, Bianco AR, De Placido S
Jpn J Clin Oncol 2004 Dec;34(12):747-50. doi: 10.1093/jjco/hyh132. PMID: 15640506
Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924.
Sternberg CN, de Mulder PH, Schornagel JH, Théodore C, Fossa SD, van Oosterom AT, Witjes F, Spina M, van Groeningen CJ, de Balincourt C, Collette L; European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group
J Clin Oncol 2001 May 15;19(10):2638-46. doi: 10.1200/JCO.2001.19.10.2638. PMID: 11352955

Supplemental Content

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